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Mini-antibodies efficiently block SARS-CoV-2 virus Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its dangerous new variants. These so-called nanobodies bind and neutralize the virus up to 1000 times better than previously developed mini-antibodies. In addition, the scientists optimized their mini-antibodies for stability and resistance to extreme heat. This unique combination makes them promising agents to treat COVID-19. Since nanobodies can be produced at low costs in large quantities, they could meet the global demand for COVID-19 therapeutics. The new nanobodies are currently in preparation for clinical trials. Antibodies help our immune system to fend off pathogens. For example, the molecules attach to viruses and neutralize them so that they can no longer infect cells. Antibodies can also be produced industrially and administered to acutely ill patients. They then act like drugs, relieving symptoms and shortening r

Holm kellerAntje dickmannsMax planckMetin aksuMatthias dobbelsteinEmily hendersonKim stegmannInstitute of molecular oncologyUniversity medical centerEnup foundationMax planck instituteJohannes bange lead discovery centerBiophysical chemistryDieter linkMax planck innovationJohannes bange