The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic due to the high transmission and mortality rate of this virus. The world health and economic sectors have been severely affected by this deadly virus, exacerbated by the lack of sufficient efficient vaccines. The design of effective drug candidates and their rapid development is necessary to combat this virus. In this study, we selected 23 antimicrobial peptides from the literature and predicted their structure using PEP-FOLD 3.5. In addition, we docked them to the SARS-CoV-2 spike protein receptor-binding domain (RBD) to study their capability to inhibit the RBD, which plays a significant role in virus binding, fusion and entry into the host cell. We used several docking programs including HDOCK, HPEPDOCK, ClusPro, and HawkDock to calculate the binding energy of the protein-peptide complexes. We identified four peptides with high binding free energy and docking scores. The docking results
Antimicrobial Peptides are molecules that form part of host defense mechanism in prokaryotic as well as eukaryotic cells capable of protecting against the harmful infective threats modelled by the bacteria, viruses and even fungi. The mode of action highly depends on the composition of antimicrobial peptides and he.
According to the latest report by Future Market Insights on global Antimicrobial Peptides market, the market is expected to register the growth of anticipated CAGR through 2021 and beyond. With the latest insights and statistics from the biggest pharmaceutical and healthcare device manufacturers across the globe, FM.