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Are Antidepressants Better Than Placebo for Some? Not So Fast, Researchers Caution

Recent study finding antidepressants beat placebo for 15% doesn’t account for study unblinding and includes only extremely short-term data.

Florian naudetMark horowitzJanus jakobsenJoanna moncrieffJohn warrenDrug administrationAntidepressants effectivenessAntidepressants efficacyDepression treatmentEpression treatment responseOdd treatment

No Better Outcomes After Testing for Antidepressant Drug-Gene Interactions

Pharmacogenomic testing did not improve outcomes by the end of the study. Both groups were just as likely to recover from depression.

Care research groupDepartment of veterans affairsVeterans affairsAntidepressants effectivenessAntidepressants efficacyNtidepressants genetic testNtidepressants pharmacodynamicsNtidepressants pharmacokineticsDepression treatmentEpression treatment responseEnetic testing antidepressantsOdd treatmentPharmacogenomic testing

Antidepressants No Better Than Placebo for About 85% of People

Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.

Johns hopkinsIrving kirschDrug administrationMarc stoneDrug evaluationAntidepressants effectivenessAntidepressants efficacyDepression treatmentEpression treatment responseOdd treatment

Nothing At All: How Antidepressants Failed Me

“Nothing at all” sums up my best experience with antidepressants, and the averaged efforts of the psychiatrists who prescribed them.

David mametAntidepressants efficacy

Less Than a Quarter of Those with Depression Respond to Treatment in Real Life

In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.

United kingdomPierre fabreLucie bartovaJanssen cilag pharma gmbEli lillyBristol myers squibbSiegfried kasperCelegne gmbFondazione umberto veronesiJournal of psychiatric researchSumitomo dainippon pharma coLundbeck international neuroscience foundationUniversity of viennaGernot fuggerMedical universityMedizin medien austria

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