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IMAGE: Molecular interactions of the receptor blocker JNJ-31020028 (light green; nitrogen atoms highlighted in blue, oxygen atoms in red) at the human Y2 receptor (grey); pdb: 7DDZ. With seven helices, the. view more
Credit: Diagram: Dr Anette Kaiser, Leipzig University
In order for a drug to be effective at the right places in the body, it helps if scientists can predict as accurately as possible how the molecules of that drug will interact with human cells. In a joint research project, scientists from Collaborative Research Centre 1423 at Leipzig University and the Chinese Academy of Sciences in Shanghai have succeeded in elucidating such a structure, namely that of the neuropeptide Y receptor Y2 with one of its ligands. This is the first time that a molecular blueprint for this receptor is available, which will enable the development of tailor-made new drugs, for example to treat epilepsy or cardiovascular diseases. The researchers findings have now been pu
Germany
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Leipzig
Sachsen
Shanghai
Berlin
Chinese
German
Max-delbr
Annette-beck-sickinger
German-research-foundation
Nature-communications