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 E-Mail Early results show that a new combination drug therapy is safe and effective against advanced skin cancer in patients who were not able to have their tumors surgically removed. The drug combination is among the first, researchers say, to demonstrate the potential value of a live common cold virus, a coxsackievirus, to infect and kill cancer cells. The Phase I study, led by a researcher at NYU Langone Health and its Perlmutter Cancer Center, is also among the first to show how such oncolytic viruses can safely boost the action of widely used cancer therapies that help the body s immune defense system detect and kill cancer cells. Currently, such immunotherapies are only effective in shrinking melanoma tumors in just over a third of patients who receive them.

United statesNew south walesDana farber cancer instituteEdwin zambrano acostaBernard foxCai wuDavid marchJanice mehnertDaniel medinaMarisa palmeriCasey imbergamoJoshua vieth at rutgers universityLangone healthJohn wayne cancer institute in santa monicaAnn silk at dana farber cancer instituteCarmen ballesteros merino at providence portland medical center