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Taltz® Showed Consistent, Long-Term Improvement in Key Signs and Symptoms of Axial Spondyloarthritis Through Two Years in Phase 3 Study

Deciphering telltale signs, symptoms of non-radiographic axial SpA remains a challenge

Given the limited awareness of non-radiographic axial spondyloarthritis, differentiating this disease from radiographic disease and prescribing appropriate therapy remains a key challenge, according to a presentation at the Biologic Therapies Summit. “Epidemiological knowledge in the United States about this disease is limited,” Marina Magrey, MD, the rheumatology fellowship program

Stopping IL-17 Drug for Axial Spondyloarthritis? Expect Spinal Flares

There is considerable interest in the possibility of withdrawing treatment or lowering doses of biologic therapies for inflammatory and rheumatic diseases, for reasons including potential adverse effects with long-term use and the high cost of medications. Previous studies in which tumor necrosis factor (TNF) inhibitors were withdrawn found increased rates of flare, although in one study, reducing the dose frequency of certolizumab (Cimzia) was not associated with a greater likelihood of flare. Ixekizumab is a monoclonal antibody that targets interleukin (IL)-17A and has been approved for both radiographic and nonradiographic axial spondyloarthritis. Whether treatment withdrawal after remission could be achieved with IL-17 inhibition had not previously been investigated.

The relationship between body mass index, disease activity, and exercise in ankylosing spondylitis

The relationship between body mass index, disease activity, and exercise in ankylosing spondylitis
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