The EMA has issued a positive opinion of the type II variation application of the JAK1 inhibitor filgotinib, based on testicular function safety data from two phase 2 clinical trials.
Women’s higher risk of conditions such as osteoarthritis and pain and fatigue may help to explain why overall healthcare resource use was higher in female patients with inflammatory arthritis.
"Chiropractors need education for axSpA, when to suspect, and when to refer," said Atul Deodhar, MD, medical director of rheumatology clinics at Oregon Health & Science University, Portland.
Researchers studied how gender affects the reporting of patient outcomes across commonly used scoring methods and indices in the spectrum of spondyloarthritis subtypes in a multinational study.
There was a strong, but not statistically significant, signal of reduced spinal structural damage with the combination of a selective COX-2 inhibitor and a TNF inhibitor in axial spondyloarthritis.