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New COVID-19 Lung Cell Atlas Reveals Why SARS-CoV-2 Is Different

Lung cells in patients with severe COVID become trapped in a state (indicated by the green color) that prevents the cells from repairing damage caused by the infection. The left image shows cells from a healthy lung; the right image shows lung cells from a patient who died from COVID-19. Images: Benjamin Izar / Columbia University Vagelos College of Physicians and Surgeons. Read Time: A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases.

Anjali saqiAndrea califanoRobert schwabeHanina hibshooshBenjamin izarColumbia university vagelos college of physiciansHerbert irving comprehensive cancer centerCornell universityColumbia department of pathology cell biologyColumbia university vagelos collegeCell biologyராபர்ட் ஸ்ச்சுதுவபேஹெர்பர்ட் இவிஂக் விரிவான புற்றுநோய் மையம்கார்னெல் பல்கலைக்கழகம்செல் உயிரியல்

New cell atlas of COVID lungs reveals why SARS-CoV-2 is deadly and different

E-Mail NEW YORK, NY (April 29, 2021) A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases. Led by researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, the study found that in patients who died of the infection, COVID-19 unleashed a detrimental trifecta of runaway inflammation, direct destruction and impaired regeneration of lung cells involved in gas exchange, and accelerated lung scarring. Though the study looked at lungs from patients who had died of the disease, it provides solid leads as to why survivors of severe COVID may experience long-term respiratory complications due to lung scarring.

Cornell universityNew yorkUnited statesMailman school of public healthColumbia universityArnolds hanOlivier elementoEli lillyBenjamin izarDenis schapiro harvardHuachao huangAjay nairAveline filliolYinshan fangRobert schwabeOlivier elemento cornell

Oncology - Studying cancer genomes gene by gene could improve treatment | Science & technology

Oncology It is a new approach to precision medicine P RECISION MEDICINE holds that, because people are unique, so too are their diseases. It aims to prescribe treatments tailored to the genetic and biochemical characteristics of individual patients. Achieving this, in the context of oncology, is the purpose of the Cancer Dependency Map (DepMap), which is being developed jointly by the Wellcome Sanger Institute, near Cambridge, in Britain, and the Broad Institute in the city in Massachusetts of that name. Cancer is a good candidate for the application of precision medicine. because it arises when previously well-behaved cells start reproducing uncontrollably, usually as a result of a mutation in their genetic code. Numerous mutations can have this result, so many tailored treatments may be possible. DepMap seeks to find both mutations and treatments.

United kingdomUnited statesAndrea califanoSanger depmapDepmap petriJesse boehmMatthew garnettFiona behanBroad instituteSanger instituteWellcome sanger instituteColumbia universityCancer dependency mapஒன்றுபட்டது கிஂக்டம்ஒன்றுபட்டது மாநிலங்களில்ஜெஸ்ஸி போஹம்

Les scientifiques de DarwinHealth publient une recherche fondamentale identifiant les mécanismes de régulation contrôlant les états des cellules cancéreuses et la réponse aux médicaments

Les scientifiques de DarwinHealth publient une recherche fondamentale identifiant les mécanismes de régulation contrôlant les états des cellules cancéreuses et la réponse aux médicaments
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New yorkUnited statesJust asHelen wuAndrea califanoEvan paullMariano alvarezSalud carlosAsuntos economicosMission of darwinhealthNational institutesVirtual inferenceProfessor andrea califanoAnd instituto de salud carlos iiiMinisterio de asuntos economicos areMaster regulator

DarwinHealth-Wissenschaftler veröffentlichen Grundlagenforschung, die regulatorische Mechanismen identifiziert, die den Zustand von Krebszellen und die Reaktion auf Medikamente kontrollieren

DarwinHealth-Wissenschaftler veröffentlichen Grundlagenforschung, die regulatorische Mechanismen identifiziert, die den Zustand von Krebszellen und die Reaktion auf Medikamente kontrollieren
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

New yorkUnited statesHelen wuDarwinhealth cso mariano alvarezAsuntos economicos transformacionAndrea califanoMariano alvarezSalud carlosWays for researchBe coBits nuclearBiology at the university system colombiaColombia universityUniversity to darwinhealthDarwin healthNational institute