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Study: Membrane around tumors may prevent metastasis
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Could Surprising Basement Membrane Property Be Harnessed to Constrain Tumors and Prevent Metastasis?
March 10, 2021
Source: Christoph Burgstedt/Science Photo Library/Getty Images
Studies by scientists at Massachusetts Institute of Technology (MIT), Beijing Normal University, and the University of California, San Diego (UCSD) have generated new insights into the elastic properties of the basement membrane (BM) that sheaths breast cancer tumors, which could feasibly lead to new strategies for preventing tumor metastasis. Their results, reported in
Proceedings of the National Academy of Sciences (
PNAS), demonstrated that while this basement membrane is elastic, it also become stiffer as it expands. The team suggested that this property may help basement membranes control how tumors grow, and might also be harnessed to prevent tumor cells from breaking out and spreading to other sites.