Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options1. No new antibiotic chemical class with activity against A. baumannii has reached patients in over 50 years1. Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB. The mechanism of action of this molecule class involves blocking the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane, through inhibition of the LptB2FGC complex. A clinical candidate derived from the MCP class, zosurabalpin (RG6006), effectively treats highly drug-resistant contemporary isolates of CRAB both in vitro and in mouse models of infection, overcoming existing antibiotic resistance mechanisms. This chemical class represents a promising treatment paradigm for patients with invasive infections due to CRAB, for whom current treatment option
Gale and Ira Drukier Prize in Children s Health Research Awarded to Johns Hopkins Medicine Infectious Disease Specialist | Newsroom cornell.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from cornell.edu Daily Mail and Mail on Sunday newspapers.
Shoot Like A Girl Releases 2020 Annual Report Ammoland Inc. Posted on
Shoot Like a Girl continues to empower and educate new women shooters
U.S.A. –-(AmmoLand.com)- Shoot Like A Girl has released its annual report for the 2020 calendar year, announcing a full tour schedule, impressive attendance numbers and impactful results in spite of current events. Shoot Like A Girl was proud to, once again, host an extremely diverse group of women in age, ethnicity, political point of view and economic level at mobile range events last year. The mobile range traveled over 20,000 miles to conduct 22 events as part of the 2020 Coast to Coast Tour, and more than 2,701 women (and some men) were introduced to the shooting sports in 2020. The full report is available online.