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New results challenge the current understanding of medulloblastoma
Scientists at St. Jude Children s Research Hospital and their colleagues have published a detailed account of SJMB03, a clinical trial for pediatric patients with medulloblastoma.
Additionally, they report results of the largest analysis of matched primary and relapsed medulloblastoma tumors to date. In both the clinic and the lab, results underscore the need for integrated molecular assessment of these tumors. The papers were published recently in the
Journal of Clinical Oncology.
Clinical trial confirms subgroups, highlights need for additional analysis
Medulloblastoma is among the most common malignant pediatric brain tumors. Previous research by St. Jude scientists and others has classified medulloblastoma into four distinct molecular groups: WNT and SHH (which are driven by their namesake genetic mutations), Group 3, and Group 4.