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To turn off disease-causing genes, Talus Bio wants to knock proteins off of DNA

To turn off disease-causing genes, Talus Bio wants to knock proteins off of DNA
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Lindsay pinoUniversity of washingtonAlex federationTalus bioAltius instituteBiomedical sciencesDemo dayபல்கலைக்கழகம் ஆஃப் வாஷிங்டன்ஆல்டிஸ் நிறுவனம்உயிர் மருத்துவ அறிவியல்டெமோ நாள்

Epigenomic Map Identifies Candidate Mechanisms for 30,000 Gene Loci Linked to 540 Traits

Epigenomic Map Identifies Candidate Mechanisms for 30,000 Gene Loci Linked to 540 Traits February 4, 2021 A team of researchers at Massachusetts Institute of Technology (MIT) has published what it claims is the most comprehensive map yet of human noncoding DNA. The EpiMap (Epigenome Integration across Multiple Annotation Projects) resource offers an in-depth annotation of epigenomic marks modifications indicating which genes are turned on or off in different types of cells across 833 tissues and cell types. This represents a significant increase over prior coverage, the team said. The researchers also identified groups of regulatory elements that control specific biological programs, and uncovered candidate mechanisms of action for about 30,000 genetic variants linked to 540 specific traits. They have made all of their data publicly available for use by the broader scientific community.

United kingdomCarles boixManolis kellisWouter meulemanBenjamin jamesBroad instituteArtificial intelligence laboratoryUniversity of british columbiaMassachusetts institute of technologyAltius institute for biomedical sciencesMassachusetts instituteEpigenome integrationMultiple annotation projectsYongjin parkBritish columbiaAltius institute

Epigenomic map reveals circuitry of 30,000 human disease regions

E-Mail CAMBRIDGE, MA Twenty years ago this month, the first draft of the human genome was publicly released. One of the major surprises that came from that project was the revelation that only 1.5 percent of the human genome consists of protein-coding genes. Over the past two decades, it has become apparent that those noncoding stretches of DNA, originally thought to be junk DNA, play critical roles in development and gene regulation. In a new study published today, a team of researchers from MIT has published the most comprehensive map yet of this noncoding DNA. This map provides in-depth annotation of epigenomic marks modifications indicating which genes are turned on or off in different types of cells across 833 tissues and cell types, a significant increase over what has been covered before. The researchers also identified groups of regulatory elements that control specific biological programs, and they uncovered candidate mechanisms of action for about 30,000 geneti

United kingdomCarles boixManolis kellisWouter meulemanBenjamin jamesBroad instituteArtificial intelligence laboratoryUniversity of british columbiaNational institutes of healthAltius institute for biomedical sciencesYongjin parkBritish columbiaAltius instituteBiomedical sciencesEpigenome integrationMultiple annotation projects