Using the DeLone and McLean (D&M) Model, the study explains the differences between female and male students’ accessibility to E-learning portals. This study compares female and male student groups regarding the usage of the E-learning portal in the higher education context. Using an online google survey, the data were collected from 254 students, including males and females. The study utilized PLS-SEM to perform a multi-group analysis examining female and male student groups. The multi-group analysis followed the MICOM procedure, and SmartPLS three was utilized to analyze the data. The study found a significant and direct relationship of E-service quality with system use and user satisfaction. System quality also supported the relationship with user satisfaction. The study further revealed a significant and positive relationship between system use and user satisfaction with E-learning portal success. This study found a direct relationship between system quality and user satisfa