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How is Metastatic Breast Cancer Treated?

How is Metastatic Breast Cancer Treated?
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Clinical Challenges: Options After CDK4/6 Inhibitors in Breast Cancer

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Clinical Challenges: Acquired Endocrine Resistance in Breast Cancer

email article Most patients with hormone receptor (HR)-positive metastatic breast cancer should receive up to three lines of endocrine therapy as part of guideline-recommended care before starting chemotherapy, said Hope S. Rugo, MD, director of Breast Oncology and Clinical Trials Education at the Helen Diller Family Comprehensive Cancer Center of the University of California San Francisco. Almost every patient will acquire resistance to endocrine therapy over time, Rugo told MedPage Today. Some patients will develop resistance in the first year of treatment sometimes within months and some can stay on their first-line endocrine therapy for 7 to 10 years. We don t have a clear understanding of the specific factors that control time to development of acquired resistance, although there are clearly clinical and biologic indications of risk.

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