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 E-Mail IMAGE: Professor of human genetics and epidemiology, University of Pittsburgh Graduate School of Public Health. view more  Credit: University of Pittsburgh PITTSBURGH, May 5, 2021 - Despite decades of research and investment, the genetic underpinnings of Alzheimer s disease are still largely unknown, stymieing drug development and early diagnosis efforts. A new $10.7 million, five-year project led by the University of Pittsburgh Graduate School of Public Health and Washington University School of Medicine in St. Louis aims to change that with the first comprehensive study using whole genome sequencing to address a critical gap in knowledge about the disease. With funding from the National Institute on Aging, the research team plans to identify the genetic variants, genes and pathways that lead to formation of plaques and tangles, two specific biomarkers that begin accumulating in the brains of people with Alzheimer s 15 to 25 years before they show symptoms.

United statesAllison hydzikCarlos cruchagaIlyas kambohSheila davisWashington universityPitt public healthNational institute onWorld health organizationKnight alzheimer disease research centersWashington university school of medicinePittsburgh graduate schoolPublic healthWashington university schoolNational institutePitt public