The data didn’t make sense.
Five years ago, University of Maryland researcher Alisa Morss Clyne was studying pulmonary hypertension a type of high blood pressure that affects the arteries in the lungs in human cells she had cultured in her lab. But the results she was seeing just didn’t stack up.
“We had these huge error bars. It didn’t make any sense,” she said. “And we said, OK, let’s just graph it by male versus female, and what we found was really interesting.”
The blood vessels in the lungs of people with pulmonary hypertension take up more glucose, and she found the female cells metabolized the glucose in way that changed a protein that was critical to blood vessel function.
Sex differences play roles in how patients respond to brain diseases
Men and women are impacted differently by brain diseases, like Alzheimer s disease and Parkinson s disease. Researchers are urging their colleagues to remember those differences when researching treatments and cures.
In APL Bioengineering, by AIP Publishing, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments.
That is progress from just a few years ago, said Alisa Morss Clyne, director of the university s Vascular Kinetics Laboratory.
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Males and females are impacted differently by brain diseases, like Alzheimer s disease and Parkinson s disease. Researchers are urging their colleagues to remember those differences when researching treatments and cures.
In
APL Bioengineering, by AIP Publishing, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments.
That is progress from just a few years ago, said Alisa Morss Clyne, director of the university s Vascular Kinetics Laboratory. I have worked with vascular cells for 20 years and, up until maybe about five years ago, if you asked if the sex of my cells mattered at all, I would have said no, Clyne said. Then, she worked on a difficult study in which data appeared all over the place.
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