New 3D Bioprinting Technique Directs Cell Orientation at Individual Cell Level
Written by AZoMMay 6 2021
3D bioprinting has the ability to make engineered scaffolds that imitate natural tissue. Regulating the cellular organization inside those engineered scaffolds for regenerative applications is a complicated and tough process.
Biofabrication of multicompartmental hydrogel fibers for the formation of multiscale biomimetic constructs. Image Credit: Mohamadmahdi Samandari, Fatemeh Alipanah, Keivan Majidzadeh-A, Mario M. Alvarez, Grissel Trujillo-de Santiago, and Ali Tamayol.
Cell tissues have the tendency to be highly ordered with regards to spatial distribution and alignment, hence bioengineered cellular scaffolds for tissue engineering applications should closely match this orientation to be able to work similar to natural tissue.
IMAGE: Biofabrication of multicompartmental hydrogel fibers for formation of multiscale biomimetic constructs. view more
Credit: Mohamadmahdi Samandari, Fatemeh Alipanah, Keivan Majidzadeh-A, Mario M. Alvarez, Grissel Trujillo-de Santiago, and Ali Tamayol
WASHINGTON, May 5, 2021 - 3D bioprinting can create engineered scaffolds that mimic natural tissue. Controlling the cellular organization within those engineered scaffolds for regenerative applications is a complex and challenging process.
Cell tissues tend to be highly ordered in terms of spatial distribution and alignment, so bioengineered cellular scaffolds for tissue engineering applications must closely resemble this orientation to be able to perform like natural tissue.
In
Applied Physics Reviews, from AIP Publishing, an international research team describes its approach for directing cell orientation within deposited hydrogel fibers via a method called multicompartmental bioprinting.