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 E-Mail Credit: McMaster University Hamilton, ON (April 14, 2021) - Modified immune cells that ruthlessly kill cancerous tumours may prove a game-changer for people living with late-stage cancer. McMaster University researchers Ali Ashkar and Sophie Poznanski have uncovered that changing the metabolism of natural killer (NK) immune cells allows these cells to overcome the hostile conditions found inside tumours and destroy advanced ovarian and lung cancer. In the past decade cancer immunotherapy has achieved tremendous therapeutic effects in patient with blood cancers. However, the immunosuppressive conditions found inside solid tumours, whose aggressive growth starves surrounding healthy tissues of energy, have until now remained a formidable barrier for immune cell therapies.

Sophie poznanskiAli ashkarHal hirteVeronica mcguireMcmaster universityCancer centre foundationCanada researchCanadian institutes for health researchFaculty of health sciencesHamilton health sciencesMaster universityMcmaster phdCell metabolismCanada research chairNatural immunityHamilton health