In a study of pancreatic cancer cells, researchers have identified three prototypical RNA-expression states and uncovered differences in their susceptibility to a variety of cancer drugs.
Pancreatic cancer cells can exist in, and transition between, three different cell states, according to new research. These states respond differently to a variety of cancer drugs, and altering the tumor microenvironment can drive tumor cells from one state to another, potentially offering a way to make them more susceptible to a particular drug.