Human T cells can target more than 1,400 sites on SARS-CoV-2 virus
In a new paper, scientists from La Jolla Institute for Immunology (LJI) bring together research findings from COVID-19 researchers around the world. The results are striking: human T cells can target more than 1,400 sites on the SARS-CoV-2 virus. Our lab and many others have shown this very broad and diverse T cell response, says LJI Research Assistant Professor Daniela Weiskopf, Ph.D., co-author of the
Cell Host & Microbe review.
This kind of research review, called a meta-analysis, pools the results of multiple studies, and the researchers give close consideration to how the studies were conducted.
Credit: CDC
LA JOLLA In a new paper, scientists from La Jolla Institute for Immunology (LJI) bring together research findings from COVID-19 researchers around the world. The results are striking: human T cells can target more than 1,400 sites on the SARS-CoV-2 virus. Our lab and many others have shown this very broad and diverse T cell response, says LJI Research Assistant Professor Daniela Weiskopf, Ph.D., co-author of the
Cell Host & Microbe review.
This kind of research review, called a meta-analysis, pools the results of multiple studies, and the researchers give close consideration to how the studies were conducted.
In the case of COVID-19, a global meta-analysis of T cell response studies is especially helpful because different patient populations can have vastly different immune responses, based on their genetic differences and past disease history.
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Immune system’s T cells can mount attacks against many coronavirus targets even on new variants, LJI says
An electron micrograph shows SARS-CoV-2 particles isolated from a patient.
(National Institute of Allergy and Infectious Diseases)
By La Jolla Institute for Immunology
Jan. 27, 2021 4:11 PM PT
A new study led by scientists at the La Jolla Institute for Immunology suggests that T cells try to fight SARS-CoV-2, the coronavirus that causes COVID-19, by targeting a broad range of sites on the virus. By attacking the virus from many angles, the body has the tools to potentially recognize different SARS-CoV-2 variants.
The new research, published Jan. 27 in
Study provides a detailed look at vulnerable sites on SARS-CoV-2
A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus beyond the key sites on the virus s spike protein. By attacking the virus from many angles, the body has the tools to potentially recognize different SARS-CoV-2 variants.
The new research, published January 27, 2021 in
Cell Report Medicine, is the most detailed analysis so far of which proteins on SARS-CoV-2 stimulate the strongest responses from the immune system s helper CD4+ T cells and killer CD8+ T cells.