The San Francisco 49ers have lost two straight games following a 5-0 start to the season. They will look to reverse that slide when they host the Cincinnati Bengals. Cincinnati is coming off a bye but has won three of four games following an 0-2 start. The Niners could be forced to turn to backup quarterback Sam Darnold with Brock Purdy dealing with a concussion. The Bengals are hoping the week off will have Joe Burrow in better condition from the injured calf that has hampered him this season.