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Roxanne Rae EnglerDec 6, 1951 — March 3, 2024

Adhesion, contractility enable metastatic cells to go against the grain

Credit: Benjamin Yeoman Bioengineers at the University of California San Diego and San Diego State University have discovered a key feature that allows cancer cells to break from typical cell behavior and migrate away from the stiffer tissue in a tumor, shedding light on the process of metastasis and offering possible new targets for cancer therapies. It has been well documented that cells typically migrate away from softer tissue to stiffer regions within the extracellular matrix a process called durotaxis. Metastatic cancer cells are the rare exception to this rule, moving away from the stiffer tumor tissue to softer tissue, and spreading the cancer as they migrate. What enables these cells to display this atypical behavior, called adurotaxis, and migrate away from the stiffer tumor hasn t been well understood.

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