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 E-Mail Credit: UEF/ Raija Törrönen Researchers at the University of Eastern Finland have discovered previously unknown non-coding RNAs (ncRNAs) involved in regulating the gene expression of vascular endothelial growth factors (VEGF), the master regulators of angiogenesis. The study, conducted by the research groups of Associate Professor Minna Kaikkonen-Määttä and Academy Professor Seppo Ylä-Herttuala, provides a better understanding of the complex interplay of ncRNAs with gene regulation, which might open up novel therapeutic approaches in the future. The results were published in the Molecular and Cellular Biology Journal. Over the past years, the development of next generation sequencing techniques has revealed that around 97% of the human transcriptome is transcribed as non-coding RNAs, and although the role of the vast majority remains uncharacterized, many functions such as gene regulation have been proven.

Landskapet birkalandNihay laham karamMinna kaikkonenCentre of excellenceAcademy researchAi virtanen institute for molecular sciencesFinnish cultural foundationAcademy professor seppo ylUniversity of eastern finlandFinnish foundation for cardiovascular researchAcademy of finlandEuropean research councilEastern finlandAssociate professor minna kaikkonen mCellular biologyMetabolic diseases