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Cornell Professors Explain Possible Risks and Benefits of COVID-19 Antiviral Treatment

Cornell Professors Explain Possible Risks and Benefits of COVID-19 Antiviral Treatment
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Canadian researchers lead development and testing of promising treatment for COVID-19 variants

May 14, 2021 “In this study, we report a novel and highly potent small-molecule drug called N-0385, that acts as the most effective entry inhibitor to date,” says Dr. François Jean, a project lead and professor in the department of microbiology and immunology at UBC. “We demonstrate that N-0385 is broadly protective against infection and mortality in mice, and believe N-0385 has potential as a viable early treatment option against emerging SARS-CoV-2 VOCs.” Dr. François Jean Viable treatments for variants of concern (VOC) are urgently needed as they carry mutations in the virus spike protein that allow them to spread more easily, and cause more serious illness. VOCs may also be more resistant to antibodies produced by vaccines.

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