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Nivolumab Plus Talazoparib Does Not Induce Responses in Heavily Pretreated Melanoma

Nivolumab plus talazoparib did not produce RECIST-based tumor responses in heavily pretreated patients with unresectable or metastatic melanoma.

Ohio
United-states
James-isaacs
Department-of-hematology
Medical-oncology
Cleveland-clinic
Cleveland-clinic-gross-family-melanoma-registry
Nivolumab
Talazoparib
Opdivo
Talzenna
Nivolumab-plus-talazoparib

Proteogenomic Signatures Shed Light on Prostate Cancer Recurrence Risk in Select Ancestries

A proteomics analysis revealed significant variations in protein expression and informative markers between African vs European prostate tumors.

Rockville
Maryland
United-states
South-korea
Han
Cara-schafer
Prostate-disease-research
Department-of-surgery
Uniformed-services-university-of-the-health-sciences
Henrym-jackson-foundation
Research-network
Johnp-murtha-cancer-center

PSMA-Directed Targeted Alpha Therapy Shows Activity in Heavily Pretreated Metastatic CRPC

FPI-2265 showed promising activity in patients with metastatic castration-resistant prostate cancer which was similar to prior safety and efficacy data reported.

Houston
Texas
United-states
Ebrahim-delpassand
Nuclear-oncology-center
Enrollment-criteria
Excel-diagnostics
Aacr-annual-meeting
Crpc
Prostate-cancer
Fpi-2265
Phase-2-tatcist-trial-nct05219500-

Novel CAR T-Cell Therapy HR001 Demonstrates Efficacy in R/R Non-Hodgkin Lymphoma

The novel CAR T-cell agent HR001 was effective, with durable responses and a favorable safety profile observed, in relapsed/refractory non-Hodgkin lymphoma.

Shanghai
China
Yian-zhang
Zhongshan-hospital-fudan-university
Aacr-annual-meeting
News
Conference
Nhl
Hr001

RGI-2001 Plus Tacrolimus/Methotrexate Demonstrates Protective Effect From Acute GVHD Post Allo-HSCT

Prophylactic treatment with RGI-2001 plus tacrolimus and methotrexate led to a lower incidence of acute GVHD vs CIBMTR control following allo-HSCT.

Calvink-lee
Pfizer
Aacr-annual-meeting
Rgi-2001
Tacrolimus
Methotrexate
Hematologic-oncology
Phase-2b-rgi-2001-301-trial-nct04014790-

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