Crohnâs Disease Treatment Studied in Mouse Model and Patient-Derived T Cells
December 23, 2020
A University of Alabama at Birmingham (UAB)-led research team has demonstrated a potential preventive treatment for Crohn’s disease, both in a mouse model and through the use of immune-reactive T cells from patients with the inflammatory bowel disease.
The researchers, headed by professor of medicine Charles O. Elson, MD, used a triple-punch treatment to remove T memory (Tm) cells and increase the number of T regulatory, or Treg, cells. This strategy prevented colitis in a T cell transfer mouse model, and similar inhibitory effects were also seen on immune-reactive CD4+ T cells isolated from Crohn’s disease patient blood samples.