Police in Cumberland County have charged a woman with murder, homicide by vehicle, DUI and other offenses in connection with a fatal crash.East Pennsboro Township police said Krystin Marchese, 33, was driving under the influence of controlled substances when she caused the four-vehicle collision Tuesday afternoon on North Enola Road.According to a criminal complaint, Marchese's pickup drifted into the center turn lane and hit a Mitsubishi waiting to turn onto Susquehanna Avenue. The pickup then careened into oncoming traffic, hitting a Lexus and clipping another vehicle, the complaint alleges.Police said the driver of the Lexus, 58-year-old Lee Potteiger, of Lewisberry, was killed in the crash.Two people in the Mitsubishi were taken to a hospital.The criminal complaint alleges Marchese was driving on a suspended license.Police said Marchese told them she was addicted to heroin and fentanyl but hadn't used in two days. Court documents also allege she admitted to taking two Xanax pills not prescribed to her before she headed to New Cumberland to buy fentanyl.Marchese was denied bail and is in Cumberland County Prison, police said.