At this moment in history, humanists, skeptics, and freethinkers cannot afford to be complacent. They must be vigilant and resist the slow undoing of human and intellectual progress by religious fanatics. The threats of religious extremism and superstition-based abuses are real. They are not African or American. They are global. And in an increasingly interconnected and interdependent world, critical thinkers and rationalists must cooperate and synergize to confront these threats anywhere in the world.