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IMAGE: The image shows the development of neurodegenerative pathology resulting from low levels of the protein Rbbp7 (on the left), compared with normal levels associated with a healthy brain (on the...
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Credit: Shireen Dooling for the Biodesign Institute at ASU
Since the discovery of Alzheimer's disease over a century ago, two hallmarks of the devastating illness have taken center stage.
The first, known as amyloid plaques, are dense accumulations of misfolded amyloid protein, occurring in the spaces between nerve cells. Most efforts to halt the advance of Alzheimer's disease have targeted amyloid protein plaques. To date, all have met dispiriting failure.