Transcripts For WHYY Frontline 20141015

I remember the doctor saying, weve discovered troy has kpc, and said, were going to move him to the isolation unit. This is a pretty serious infection. This is one of those superbugs. Narrator tonight, two important stories, one exclusive hour frontline. Frontlinis made possible by contributions to your pbs station from viewers like you. Thank you. And by the corporation for public broadcasting. Major support for frontliis provided by the john d. And catherine t. Macarthur foundation, committed to building a more just, verdant and peaceful world. More information is available at macfound. Org. Additional support is provided by the park foundation, dedicated to heightening Public Awareness of critical issues. The ford foundation, working with visionaries on the front lines of social change worldwide. At fordfoundation. Org. The wyncote foundation. And by the frontline journalism fund, with major support from jon and jo ann hagler. David hoffman for the past two years, i have been investigating the emergence and spread of nightmare bacteria superbugs that are increasingly resistant to even the strongest antibiotics. The bacteria are fighting back and theyre defeating the drug. Correct. Hoffman id been tracking the phenomenon through hospitals around the country, where doctors have been dealing with patients infected by these superbugs, which go by names like kpc and ndm 1. All these rs mean that the bacteria is resistant to that antibiotic. Hoffman id found outbreaks that have paralyzed some of our best hospitals. And no matter what we did, the bacteria was still. It was still spreading. Hoffman more than 20,000 people a year are dying from these infections, and as many as two million get sick from them. Whats become apparent is that these nightmare infections are being fueled by the overuse of antibiotics, creating bugs we cant kill. But the more i looked into it, the more i saw there was another dimension to the story. It turns out most antibiotics arent even used by humans. Theyre used on farms. Getting onto a farm wasnt easy. The use of antibiotics in agriculture has become such a sensitive subject that most farms wont let cameras in. But one in north georgia agreed, as long as we didnt reveal its name. Whats your big goal . The farms veterinarian, chuck hofacre, showed me how antibiotics have become essential to industrialscale farming. My big goal is to prevent disease, and thats what almost all food animal veterinarians today focus more on stopping disease introduction, preventing diseases from happening rather than having sick chickens and animals that are suffering. Theres a light switch here somewhere. Im looking at trying to prevent any Health Issues in this small city of chickens of 100,000. Hoffman it is like a small city, isnt it . Yes, because once they get sick, just as in a city, the disease can then spread through the population fairly quickly. Hoffman this is what hofacre wants to prevent. This chicken was sick because of an intestinal disease. Hoffman so this is a signal to you that its time to use an antibiotic to prevent this from spreading. That is correct. Hoffman chuck, what do we have here . Well, this is an antibiotic called lincomycin. Hoffman antibiotics like this are regularly put in the Drinking Water or added to the feed of healthy animals, most of the time without a prescription. Empty the antibiotic into the water. Water coming out of this bucket with the antibiotic will be injected into their water. And then that water will then go on into the Chicken House, and well be at the proper dosage. Hoffman its estimated that as much as 70 of all antibiotics sold in the United States go to farms. They drink out of these nipples and they eat from these feeders. That helps the flock grow better. The farmer does better because they have more pounds of meat. Gives the consumer a cheaper food supply. The chickens are healthier, so healthy chickens mean a healthier product for the consumer as well. Hoffman but increasingly, this widespread use of antibiotics in animals has been raising concerns. Is it possible theres a pathway . Im thinking particularly of resistance, you know . Could it go in bugs from the Chicken House to the family table . We dont know how often that occurs. We think that it probably occurs at a very, very low rate. That linkage is very difficult to connect the dots. Hoffman scientists have long been looking for connections between these dots, trying to understand whether the use of antibiotics on farms is contributing to antibiotic resistance that threatens the health of people. As i dug in, i began to find new evidence that was complicated and surprising. Hoffman my investigation took me to flagstaff, arizona, where id heard about some of the Newest Research being done. Flagstaffs hospital has seen a rise in urinary Tract Infections that are increasingly resistant to antibiotics. Okay, we have the lady in room 12, she came in two days ago with the e. Coli in her urine. Right. Well, it came back this morning as being a resistant organism, so we had changed from zosyn to a carbapenem. Hoffman these infections strike an estimated eight million americans every year. Like in flagstaff, doctors around the country are struggling to treat them. Looks like its only preliminary, but looks like its a gram negative rod. Were seeing a lot more patients that were previously normally healthy have to be admitted because theyve gone through multiple outpatient courses of antibiotics, they havent improved, and at the point that they come in, that bacteria has gone into their bloodstream. And that requires immediate hospitalization. You dont have a normally healthy 30yearold woman come in whos never been in a hospital, with a resistant urinary tract infection thats moved to her blood. Where did she get that organism from . Hoffman this problem caught the attention of a genetic researcher, who had a theory about where some of these infections could be coming from. So this is the meat section, and this is where our team spent a good part of their year last year, buying two packages of every brand of chicken, turkey and pork. No expiration. This is chicken, i want to get some organics, so ill get two of these organics. Hoffman lance price started sampling the meat supply in flagstaff in 2012, trying to figure out if resistant bacteria from farms is ending up on the meat we buy. We started this study because we had this hypothesis, this theory that food could serve as a source of e. Coli that then went on to cause urinary Tract Infections. Could i get two pounds of the ground turkey, but could i get it in two separate packages . Hoffman price isnt concerned with the trace amounts of antibiotics that could be in meat. Hes looking for antibiotic resistant bacteria that could be on the meat and cause dangerous infections if they end up on our hands or kitchen counters, or if the meat isnt cooked enough. Were producing nine billion food animals, and by using antibiotics in food animal production, we are creating drugresistant pathogens that can then go on and cause drugresistant infections in you and me. These guys expire on the 6th. The problem with urinary Tract Infections is that if you get a bladder infection with e. Coli and its antibiotic resistant and the doctor goes to treat you and that treatment fails because the bacteria is resistant, then it can get in the kidneys, and once its in your kidneys, it has access to your blood, right . And so then you can get what we call sepsis, which kills 40,000 americans each year. Hey, thanks a lot. Were going to put it into a broth, were going to put it in the incubator and want to see if we can grow e. Coli from it. Hoffman what price wanted to know is whether the meat aisles of flagstaffs supermarkets were the source of some of the dangerous urinary Tract Infections that were showing up in the local hospital. His study would take several years. Sooie sooie hoffman the widespread use of antibiotics on farms goes back decades. They were first used on animals in the 1940s. Among the many valuable new products created in agricultural laboratories are massproduced antibiotics. It was at a time when agriculture was really changing and really becoming much more of a. At that time, it was not a pejorative, but it was an industrial model. So farms were getting bigger. Animals were getting put closer together. When you put the animals closer together and have them confined, then its a lot easier to pass diseases back and forth. Giving them a little bit of antibiotic sort of seemed to fix that problem, or sort of put a bandaid over it anyway. Hoffman but there was another benefit, one they had not anticipated. The power to promote growth. Note the weight of a chicken raised for eight weeks on a regular feed. Now another chicken, nourished for the same period on regular feed plus terramycin a 15 increase in growth. They had discovered that if you add these drugs to the feed of animals, they were very useful in increasing the productivity of the animal. They kept them healthy. That was the main thing. They reduced loss in sicknesses in their animals, and they also discovered that it gains the same amount of weight on less feed. Feed is a very big cost. Want Something Special for sunday dinner . Chicken, inspected and graded, is now thrifty every day. People dont realize how expensive chicken used to be. Hoffman so antibiotics helped us get to inexpensive chicken . Inexpensive and Higher Quality chicken, yes, Higher Quality chicken. And pork and beef as well. Hoffman with the help of antibiotics, American Meat production has tripled over the last 50 years. But with the growth also came concerns. As early as the 1960s, the British Government sounded an alarm in a study called the swann report. This was a milestone report. They said that antibiotics shouldnt be used to get the animals to grow faster because one of the unintended consequences was antibiotic resistance. Yes, it was an economically shortterm good, but in the long term, antibiotic resistance was a real problem. Hoffman but the report did not establish a direct link between farm antibiotics and human illness, and thats still the question today. Im not saying that the use in Animal Agriculture doesnt contribute to resistance at all. Of course we see resistance in veterinary medicine from the use of antibiotics. But theres a lot of unknowns as well. We really have not shown that direct pathway from you gave this animal that drug and some person somewhere down the line ate meat from that animal and they now have a resistant infection because you gave that drug way back here. Hoffman in central pennsylvania, i came across researchers tackling this scientific challenge in a different way. Theyre trying to track how resistance might travel through the environment, from farms to people. We came to central pennsylvania for this research because there are a lot of swine animal feeding operations here. Hoffman joan casey is an epidemiology fellow at the university of california at berkeley. Five years ago, when she was studying for her ph. D. , she became interested in antibiotic resistance. I basically just started reading about it and trying to find out what was known about antibiotic use and farm animals. Hoffman casey found research from europe suggesting that an antibioticresistant bacteria called mrsa, which can cause deadly skin infections, was traveling from pig farms to people. She wanted to know if the same thing was happening here. If People Living close to huge animal feeding operations were at risk for getting infections from these operations. Hoffman to try to answer that question, casey turned to geissinger, one of central pennsylvanias Largest Health care provider, where she joined forces with brian schwartz. Almost four Million People live in this region, right . Hoffman as senior researcher, he had access to a trove of medical data. We were able to get about 160 million electronic records on about 450,000 patients from the region. Hoffman and what did you find . Total mrsa from 2001 to 2009 straight up, incidence up every year. Hoffman they found mrsa infections had been rising as much as 34 a year in central pennsylvania. And the patients werent typical. People are getting mrsa who are not like the ones who used to get it. Theyre not old, sick people. These are young, healthy people. Hoffman and when they compared that data with the location of pig farms in the area, a pattern started to emerge. This is the location of where all of the people with mrsa infections live. Each red dot is a person that had a mrsa infection. So these are all their home addresses. Hoffman right. So what i can show you here is the location of the swine operations in this region. Each of these barns represents a large, confined animal feeding operation. Hoffman so lets look at this next one. Yeah so let me show this to you. Hoffman so what is this . So theres some nice overlap youll see between where the mrsa cases are and where these large swine farms are. You can see that theres some people with these infections living very close to animal feeding operations. And this is the only study thats really been done in the United States thats looked at rural areas and mrsa infection. Hoffman their theory was that the mrsa causing some of the infections was coming from pig manure. Every year in this area, theres about 600 million gallons of animal manure spread onto crop fields. When you have antibiotics in animal feeds, the manure is loaded with undigested antibiotics. Its loaded with antibiotic resistant bacteria. And its loaded with the genes that the bacteria can transfer back and forth to each other that allowed them to become resistant. Hoffman but help me understand, how does it get from being put on a field as fertilizer for crops to threatening me, living in my house . So you put the manure on that crop field and it doesnt rain for a month, and the soil gets dusty and a big wind comes by. It goes airborne. It can travel by air. Or conversely, a big rainstorm comes by and all the mrsa gets washed off into the drainage off of the field and into the local streets and onto the neighbors lawns. We actually found that People Living closer to these farms and to the crop fields that are located nearby were about 38 more likely to have a mrsa infection than People Living farther away. Right now, i think the best hypothesis that we have is that its coming from industrial agriculture. Hoffman but to the farmers and drug makers, the study was just more unsettled science and speculation. Well, i think the study was very interesting, and it showed some associations. But i think the implication is that antibiotic use somehow caused the problem, and theres no evidence that that is the case. They didnt test any of the manure, so they have no data on what was actually in the manure. So their study was more speculative than anything. Hoffman why didnt you just take a trowel and dig up some of that crop field where the manure was and test it yourself as part of the study . Well, it costs a lot more money, and we didnt have the money for that, and you also need permission to go on peoples crop fields, and in general, getting access to the farm operations has not been easy. Hoffman in the end though, arent you really speculating about the link based on a pattern . We have not made any definitive links, but i think theres mounting evidence that theres a problem. Hoffman making sense of the science isnt easy. I went to the cdc in atlanta, where they closely track antibiotic resistance. Is it possible that the use of antibiotics in animals is breeding resistance . That farms, like hospitals, are becoming a place where resistance comes from . Well, its not only possible, i mean, its happening. I mean, we see resistance in pretty much everywhere and everything we test. So there is a certain amount of resistance in cattle, in pigs, in chickens, in humans, in the retail meat that we buy in stores. Anywhere you use antibiotics, youre going to have resistance and propagate resistance. Hoffman yet the cdc acknowledges the lack of conclusive science. Its very challenging to link the use of a particular antibiotic in a particular herd of animals to a particular human illness. I mean, that is really the challenge. So going from point a to b to c to d to e to f, tracing that bacteria all the way to person a with resistance a, i mean, thats very challenging to do because there are lots of steps in between. Hoffman the agency with the authority to regulate antibiotics is the food and drug administration. Inside their archives, i found the story of how the agency tried to reduce the use of farm antibiotics nearly 40 years ago. It was 1977. The fda had a new commissioner, a stanford microbiologist named donald kennedy. Members of my staff got some documents to me that convinced me that we really had a difficult problem to deal with. Livestock had been dosed up just to make the animals put on weight faster. Hoffman one of kennedys closest aides was tom grumbly. He had passion about this issue almost from the beginning. And the way he would express it was, look, i dont know whether antibiotic resistance is going to come more from the human use of antibiotics or from the animal use, but i know that theres really no difference. Hoffman based on the advice of top scientists, kennedy proposed restrictions on two of the most widely used farm antibiotics penicillin and tetracycline. He feared that by overusing these drugs, farmers were fueling antibiotic resistance and threatening the health of people. Were creating resistant organisms that may ultimately transfer that resistance to organisms that cause human disease. I thought we were doing exactly the right thing. The trouble is that you dont always find that as easy as you had hoped. Hoffman opposition to the proposal was immediate. Farm lobbies and Industry Groups attacked it as theoretical speculation and said it would be financially ruinous. One of the most vocal opponents was the animal drug makers group the Animal Health institute. Ahi was against that at the time. Do you remember why . Well, i wasnt at ahi at the time, so i dont know, and you say that they were, but i dont know that they were. I mean, do you have. Is there some documents that youve seen . Hoffman there is. This is actually ahis proposal to. At the time, to the docket, ahi said that the commissioners proposal is wholly illogical, would result in an arbitrary and capricious and thus illegal regulation. I think in the case of penicillin and tetracyclines, it was a theoretical concern. Back then, they didnt really have good Risk Assessment at the time. They really couldnt put the whole picture into place as to, okay, this can happen. We know it can happen in the laboratory. Does it happen in the real animal, and what is the real risk to Public Health . I think that was where they were missing the data. Hoffman the industry turned to their allies in congress, and one of their closest was mississippi congressman jamie whitten. His informal title was the permanent secretary of agriculture, a title he held for several decades. Hoffman whitten chaired the subcommittee that controlled the entire fda budget. We were at the mercy of representative whitten, who basically made it clear that he was going to cut the heck out of the fda budget. Hoffman so he said that unless you guys would study this and get more information. He was gonna cut the budget. Hoffman and thats a pretty serious threat from whitten, right . I mean, hes a powerful guy. That was no threat. That was no brag. That was truth. He would have. Hoffman the proposal was shelved. When you posed this in 1977, it wasnt settled science. You said you were confident about it. And i just wondered, did we know enough . I think there was a search for what we used to call the smoking gun that is, a particular antibiotic carried over and so forth. I think it was vulnerable enough to the argument that you havent really shown us the smoking gun that it failed in its time. Hoffman so after you tried to push for this and then it got blocked, did anything ever happen . Well, it kind of went into the deep freeze for a long time. People basically just said, this is in the too hard category, and until we get real evidence or evidence of people i hate to say it dropping in the streets, so to speak, from antibiotic resistance, that nobodys going to do anything about this. Hoffman but theres new evidence emerging that fda was on to Something Back in 1977. Morgan hey, good morning. Hoffman on a north texas feedlot. Hi, im david hoffman. I met two veterinarians who have spent years working with the cattle industry. Guy and i have been working together for the last ten or 12 years on many of these issues, actually. Weve done multiple projects on antibiotic resistance. Weve been working extensively on this and making progress. Its an evolving progress, but were making progress. Hoffman guy loneragan of Texas Tech University and morgan scott of texas a m noticed something unsettling in their research with cattle. An important antibiotic called cephalosporin was losing its effectiveness. Bacteria were becoming resistant to it, so when the cattle got sick, they were harder to treat. But the scary part was that unlike most farm antibiotics, cephalosporins are critically important to humans, too. Okay, they are so critically important because there are certain types of infections for which they are one of only few choices available to treat these infections. Ill give you one example. So clinical salmonellosis in children and in many cases pregnant females are limited. Some drug classes cant be used. Hoffman so theyre very valuable for children. Theyre very valuable, yes. Okay, let me grab a little bit of. Hoffman to try to save cephalosporins for both animals and humans, they designed a novel experiment. The idea was to use more tetracycline, an older drug less important to people, with the hope of reducing resistance to cephalosporin. Good, morgan, lets go sample. Hoffman i see, so you were hoping to essentially play a little bit of a game here, that by using one antibiotic which didnt have big consequences for human health, you could preserve and protect one that was important for human health. Exactly. Most of the world doesnt care about tetracycline resistance. They care a lot about cephalosporin resistance. So obviously, i think youre going to want these, and im going to want them too. And the lid should be there and the cup as well. Hoffman it was cutting edge science, but it started with a plastic spoon. We collected fecal samples directly from the animals. And from those fecal samples, we grew generic e. Coli. Well put the samples in the cooler ready to send. So were going to ship these down to College Station to do the microbiology work. Hoffman when they took their samples to the lab, they got a big surprise. It was like, okay, this isnt going the way we thought it would. We actually saw that resistance went up, which was not what we hypothesized. Hoffman resistance went up to cephalosporins, the drug they were trying to save. And this was what the fda had been worried about in 1977 that the use of tetracyclines could accelerate the overall spread of antibiotic resistance. The viewpoint historically has been that sure, tetracyclines arent that important for human health, so why worry about them in Animal Agriculture . But they may be more important than we think, not because of their use in human medicine, but because they can expand resistance to critically important drugs. We did it for an entire year. Hoffman back in flagstaff, arizona, lance price was closing in on his search. To see whether there is e. Coli in these foods and whether they have drugresistant bacteria in them. Hoffman he and his team had spent a year going to supermarkets. Thats a lot of chicken. Yeah, thats a lot of chicken, turkey and pork. I think thats it. Lets go. And this is the microlab. This is really the heart of our food operation. So well first have you gown up here. Hoffman at the lab, theyd been testing the meat looking for traces of dangerous e. Coli. Right, so what theyve done is theyve taken a standard frozen turkey, and these were actually purchased over thanksgiving, and then culturing the bacteria, the e. Coli. When we say that theres e. Coli on a turkey product like this, we want to know that its definitely e. Coli, and we want to know if its the e. Coli that can cause bladder infections or kidney infections or blood infections. Hoffman 20 of the meat they tested had this bad e. Coli on it, and a third of that was highly resistant. So this is an e. Coli from the food supply, and its resistant to five different antibiotics. So its resistant, resistant, resistant, resistant, resistant. So thats five different antibiotics that a physician cant use to treat an e. Coli infection. Hoffman wow. But what price really wanted to know was whether any of this bacteria had caused those urinary Tract Infections at the flagstaff hospital. This is where we grow bacteria from patient specimens. This is a person that has gramnegative bacteria. Hoffman so he got the hospital to send him more than 1,200 samples of urinary Tract Infections theyd collected from patients. So this is where weve stored all the samples that weve collected from this study, including thousands from the food supply and thousands from urinary Tract Infections that we collected at the hospital. We have these tubes, and we said, okay, lets look at the dna from the e. Coli from the people, lets look at the dna from the e. Coli in the food supply, and say, are these matched . Hoffman by using stateofthe art whole genome sequencing, he compared the samples he got from the hospital with the bacteria hed found on supermarket meat. So this is all the e. Coli that we got from the food supply and from urinary Tract Infections in flagstaff. So what the computer is doing right now is its figuring out how these things are related to one another. Hoffman price is only halfway through his study. It has yet to be peer reviewed. But he let us in on his preliminary findings. So far, he says hes genetically linked more than 100 urinary Tract Infections back to supermarket meat products, and a quarter of them were resistant to several antibiotics. For price, this supported his hypothesis that some of the dangerous urinary Tract Infections were coming from the food supply. So here is evidence that these e. Coli in the urinary tract infection, the e. Coli in the food came from the same original e. Coli population. So probably the farm. Hoffman probably the farm, but you dont really know how it got there, right . Thats a bit of a guess. When we see this, when we see such genetic relatedness like this, the alternative explanations become, you know, impossible. Hoffman but even with the hightech genomics, price still cant make all the connections. Thats because he doesnt have any data on how antibiotics are being used on the farm. I was surprised to find out that farmers arent required to report how many antibiotics theyre using, or for what purpose. So we dont even know how many antibiotics are used on turkeys as compared to chickens. No, we do not. Hoffman and we dont even know really the volume thats used for humans as compared to animals. Its a guess, right . Not really, because the data that we have is based on drugs that are being sold, not used or how theyre used. Hoffman i mean, ideally, what data would you want to know if youre tracking resistance . I think weve been clear for years, all of us, meaning the whole of government, academics, anyone who is tracking food borne infections, that we would like use data. To be able to understand resistance and where its coming from, its going to help a lot for us to have better use data so that we understand how these antibiotics are being used and where theyre being used. I mean, its just not available, and its not something that we collect. I mean, thats not our area. As was mentioned, you need to talk with fda. Hoffman the fda commissioner is margaret hamburg. Why dont we have that information . I mean, antibiotics have been used on the farm for four, five decades. Why dont we have it now . You know, for me, the question is, can we get it now . And thats what were working on. I think its really, its a question of us all working together to identify what are the Critical Data needs and. Hoffman dont you know that now, though, 40 years . I mean, shouldnt you have a better handle on that, what data you need . Well, you know, youre asking a very big question in terms of the overall picture. We are focused on certain aspects of this challenge. Hoffman last year, there were proposals in congress that would have required farmers to report in detail which antibiotics theyre using on animals and how much. But Industry Groups like the National Pork Producers Council opposed those efforts. Did you lobby against those amendments . Those amendments did not have a lot of support among congress. There was not really a need to actively lobby against them. Hoffman but you did not want those amendments to be part of that bill. We did not think theyd be helpful. Hoffman whats to be afraid of with getting more information . The people who were asking for that information are people whose motives were to restrict antibiotic use. Hoffman so you saw this as a way to get restriction, not just information. Correct. Hoffman the proposals died. And after years of inaction, the fda tried a new approach last december. It asked the pharmaceutical industry to voluntarily stop selling antibiotics that are intended only to make animals grow faster. We actually believe that by taking a voluntary approach, we are going to move towards our goal of getting these antibiotics out of use for growth promotion in a more effective and speedier way than if we actually tried to go drug by drug to pull them from the marketplace. Hoffman the drug makers agreed to phase out these socalled growth promoters over the next three years. And the fda will require greater supervision of all antibiotic use by veterinarians. Industry has told us that only 12 of the antibiotics that they sell in agriculture are used for growth promotion, so does that really mean that 88 of whats being used today will continue to be used . The action were taking is one step. But we clearly need a comprehensive strategy in terms of Animal Health and Farm Practices as well. Hoffman more than is being done today . Oh, i think, you know, we view what were doing as part of a broader process. I think fda is very cautious. And because of the history that they had in the 70s where they tried this big step and Congress Told them no, i think fda is taking some baby steps. I think they could be much bolder. I mean, we know what theyre going to do. Theyre going to do this voluntary thing, right . But if theyre not collecting the data to verify that people are changing the way theyre using antibiotics, that the program is working, you know, whats the use . How do we evaluate the success of this program without collecting data . Hoffman its been nearly 40 years since the government first tried to limit the use of antibiotics on farms. Has anything really changed in those 40 years . Yeah, the use of antibiotics has gone up. And certainly the problem of antibiotic resistance in human beings to drugs has gone up substantially. We live in a shared environment. Bacteria that we can find in animals we can find in people, and bacteria that we find in people we can find in animals. So the route by which they move between them may not be that important, but the fact that they move between the two populatiois important. Narrator coming up next on frontline. Youre watching your son die in front of you, and there is absolutely nothing you can do. Narrator a drugresistant superbug shows up in a young patient after nih doctors thought the outbreak was over. Youre in the best medical facility in the world. The doctors can do nothing. We can do nothing. Narrator outbreak at nih begins right now. Narrator nowhere is the threat of antibioticresistant bacteria more urgent than in hospitals, with their heavy reliance on antibiotics and their population of vulnerable patients. There have been problems in hospitals around the country, and over the past decade, hospitals in the new york city area have become the epicenter of a particularly resistant and deadly superbug. Its called kpc. It lives in the digestive system and can spread its resistance to other bacteria. And patients who get it in one hospital can carry the bacteria to other hospitals. That happened in a story we first told in 2013, when one of the nations most prestigious hospitals, the Clinical Center at the National Institutes of health, found itself battling a major kpc outbreak. It began in the summer of 2011, when a patient with a rare lung disease was transferred from a new york City Hospital to be treated at the nih in bethesda, maryland. She was carrying kpc. It was the first case of it the nih had ever seen. We immediately went on high alert, the equivalent of hospital epidemiology defcon 5, tried to implement as many things as we could think of at the time to prevent any further spread of the organism in the hospital. The patient was placed in what we call enhanced contact isolation, which means everybody who went in the room, including visitors, had to wear gloves and gowns. Narrator but this was the intensive care unit, where patients are very sick and highly vulnerable. Let me just check your blood sugar, okay . Its the kind of place where the bacteria can spread with ease. People are very busy and there are a lot of things going on. Patients get very sick very quickly and require intervention. The bacteria can be spread on the hands, they can be spread on pieces of equipment that might go from patient to patient, so you have to be really cautious. Narrator their efforts to contain kpc appeared to work. When other icu patients were tested for kpc. We found nothing. So at that point, we thought that there had not been spread of the bacteria. Narrator the new york patient ultimately recovered and was discharged after four weeks in the hospital. We really felt like we had dodged a bullet. Narrator but then, a big surprise. Five weeks later, unexpectedly. Can you do me a favor . Could you get me just a tube fixator out of the rt closet . A kpc bacteria turned up in a respiratory culture. Narrator and with it, a mystery. How this could have spread from the first patient to the second patient. They were not in icu at the same time, they didnt have the same caregivers, they didnt have the same equipment, so initially we thought that it might be possible that this was a second introduction of yet another kpc organism. I was extremely concerned because the infections with these bacteria had a high mortality rate. Narrator as they began to investigate, searching for kpc on equipment and testing the patients yet again, they realized the problem was much bigger. We started finding other patients in the intensive care unit to whom the bacteria had spread. Narrator they had an outbreak. The kpc was spreading. The patients were getting sicker. And antibiotics werent working. And we tried combinations of five, six antibiotics. We tried making oral antibiotics into intravenous antibiotics. We even got an investigational antibiotic from a pharmaceutical company. An experimental one, a test one. An experimental antibiotic, and that also did not work. Narrator desperate to contain the outbreak, the hospital took unprecedented steps. They created a separate icu for kpc patients. Brought in robots to disinfect empty rooms. Had monitors here reminding us to wash our hands, built a whole wall up in the other side. We moved every patient in the icu, completely cleaned it, moved patients back in, and no matter what we did, the bacteria was still. It was still spreading. We didnt know what was going on. Narrator with the hospital in crisis, genetic researchers in building 49 next door were scrambling to figure out how the kpc was spreading. We had now gotten to the point where they were identifying a patient a week, and it was not clear how these patients might be related to each other. This bacteria has the capacity to live. Narrator by comparing the dna in the kpc samples, the researchers made an alarming discovery silent carriers, people who were carrying the bacteria but showing no signs of infection, seemed to be spreading the kpc. As they urgently searched for silent carriers throughout the rest of the hospital, their Worst Nightmare came true the outbreak had spread beyond the icu. Thats a very scary moment. Suddenly, its in the general patient population. Narrator the staff was in a panic. As they looked on helplessly, patients began to die. Narrator there were few options left. Dr. Gallin asked me if we needed to close the hospital or if we needed to close the hospital to admissions. Ultimately, we decided not to close the hospital, but. It was a possibility. Absolutely. Narrator instead, they expanded testing hospitalwide and isolated all those found with kpc. Finally, six months after patient one first arrived, the outbreak appeared to have ended almost as suddenly as it had begun. We started to be a little more optimistic, and we continued all of our aggressive measures to control the bacteria in the hospital. Narrator but by then, 18 patients had been infected with kpc, and six people had died from it. No patients or their families ever come forward to talk about their experience, but after seeing our story, one family did. Not long after the scare at the nih subsided, in willmar, minnesota, 19yearold troy stulen was recovering from a bone Marrow Transplant hed received at nih months earlier. It went very well. He started recovering, and then one morning, he woke up and he had blisters all over his body. And we called the doctors at the nih, and they were concerned that maybe he would get an infection in these blisters, and so they wanted him to come back out there again. It was a huge relief to be back there again. I thought of it as being one of the best of the best hospitals in the nation, and i felt very comfortable being there. When we got there, he was in a lot of pain, and so they finally gave him some medicine for the pain, but were just thinking, okay, this is just ten days, short term, theyll get this figured out and then well go back home again. You know, not a big deal. Narrator troy had suffered Health Problems from birth. The most serious was a genetic disorder called chronic granulomatous disease. As he reached his teens, troys illness was causing serious gastrointestinal problems, and his doctors recommended he undergo a difficult and risky bone Marrow Transplant at nih. And troy was totally on board about it. He said, if i have the transplant and im cured, i win because im healthy and im normal. If i die, i win because i go to heaven. Narrator troys transplant actually took place at nih during the kpc outbreak, but he was on another floor and unaffected by it. Now that he was back, his weakened state left him dangerously susceptible to infections. As the days turned into months, his complications worsened. As the months progressed, they just couldnt figure out what to do with his skin. He was in icu probably four or five times. It was kind of a balancing act that whole time, you know, how to properly treat him whether he needed platelets, whether he needed blood, whether he needed more steroids. Basically, it got to the point where it was like, okay, whats next . Whats the next bad thing thats going to happen . Narrator then, in august 2012, the doctors brought some shocking news. Troy tested positive for kpc. It was eight months after the hospital thought the outbreak was over. When the bacteria came back, did it surprise you . That more than surprised me. I mean, that was devastating. It sort of brought back all the emotions of the fall, feeling as though we finally have this situation under control, and then a new patient being identified. I remember the doctor coming in and saying, weve discovered troy has kpc, and said, were going to move him across the hall to the isolation unit. And i kind of googled it and stuff like that and learning that, hey, this is a pretty serious infection. This is one of those superbugs. Marilyn just said, you know, im really scared about this infection. He has a low immune system, were in a hospital. Yeah, it was very scary. Its like, you know, weve got a lot of things going against us here. But he was doing okay with it, and im thinking, okay, well, maybe hell be fine. He had acquired other infections along the way, but they always had antibiotics that were used, and he was able to get through those infections. Narrator at first, troy was put on a powerful, but toxic, antibiotic called colistin. And it appeared to be working. He was testing negative for the infection and his kidney was working. It seemed like things were heading in the right direction. I was actually heading back home again, and literally a half hour before i left the hospital, the chaplain and the nurse came and asked marilyn and i if they could meet with us. They just said, you know, you need to start preparing to talk to your son about dying, the possibility of dying. They said, weve seen this infection before and it doesnt always end well. And sure enough, a few days later, the doctor said that the infection has mutated and that the colistin is no longer being effective. It wasnt long after that that his vital signs started to fail. They had exhausted all options and there was nothing more they could do. All they could do was keep him comfortable at that point. Narrator on september 7, 2012, the family gathered in troys room in the icu. That was a long day. Its very hard to watch your son, daily, starting to lose his life, and then to see him on a ventilator and not be able to do a thing about it. Its really hard. We were able to all be together for the last couple of hours, and troy passed away that evening about 7 45. Narrator the doctors said a kpc patient from the earlier outbreak had probably brought the superbug back to the hospital during a routine followup. But they were unsure how troy had come in contact with it. He was the last victim of the kpc outbreak. Do you think kpc is now gone from your hospital . Oh, no, absolutely not. I think that we have to be extremely vigilant in the coming years. The rate of these infections has risen sharply during the past decade. Narrator hospitals are generally not required to report details of outbreaks like this one to the public, but the researchers at nih believe the lessons are important and must be shared. Talking about hospital infections is really difficult for a hospital because we all know that when you come to the hospital, there are certain risks. But weve now laid bare what are those risks. We owe it to those patients to honor those patients by ensuring that this does not happen in another hospital. If i had a major message, it would be that its never going to end. This organism and organisms like this are going to be with us. We have to develop new strategies for managing them. We have to change our culture in the hospital. The surprise to me was that he didnt die from the bone Marrow Transplant, which is what, you know, if there was going to be a problem, we thought it would be tied to the bone Marrow Transplant. We never thought that it would be an infection that couldnt be cured. For more on the trouble wh antibiotics, visit our website,. We have to be extremely vigilant and visit our new ipad app at pbs. Org frontline app. Subscribe to our Youtube Channel now you can get original short frontline documentaries important stories, well told. And connect to the Frontline Community tell us what you think on facebook and on twitter, and sign up for our newsletter at pbs. Org frontline narrator next time on frontline. A special report on the war we left behind. Iraq. Theres so much at stake here. Narrator washington. Ultimately its up to the iraqis as a sovereign nation to solve their problems. Narrator how did we get here . There are no good options remaining. Narrator and what happens now . Frontline investigates losing iraq, part of a twoweek investigation on the rise of isis. Frontlinis made possible by contributions to your pbs station from viewers like you. Thank you. And by the corporation for public broadcasting. Major support for frontliis provided by the john d. And catherine t. Macarthur foundation, committed to building a more just, verdant and peaceful world. More information is available at macfound. Org. Additional support is provided by the park foundation, dedicated to heightening Public Awareness of critical issues. The ford foundation, working with visionaries on the front lines of social change worldwide. At fordfoundation. Org. The wyncote foundation. And by the frontline journalism fund, with major support from jon and jo ann hagler. Ned by mep at wgbh, access. Wgbh. Org for more on this and other frontline programs, visit our website at pbs. Org frontline. Frontlinethe trouble with antibiotics is available on dvd. To order, visit shoppbs. Org. Or ca1800playpbs. What if television. Ali i shook up the world could remember the heroes we honored . The music we danced to . The dreams we chased . Kennedy the hope still lives, and the dream shall never die. No one tells our nations story like pbs. Give to your pbs station, and help bring americas story to life. Hello and thank you for joining us on this edition of newsline. Im raja pradhan in tokyo. Heres a look at some of the stories were following this hour. American Health Authorities have moved in a special team to monitor workers at a u. S. Hospital who were exposed to the ebola virus. The operator of the Fukushima Daiichi Nuclear Plant says heavy rain could be the cause of high levels of radioactive cesium detected at the facility. And health