Nightly news begins right now. Announcer from nbc news World Headquarters in new york, this is nbc nightly news with lester holt. Good evening. Its debate night. Hillary clinton and Bernie Sanders in their first oneonone debate, just five days before the New Hampshire primary. It comes as a brandnew nbc news wall street poll showing clinton with miles of ground to make up. 58 of likely democratic voters in New Hampshire are backing sanders. Clinton with 38 . Thats virtually unchanged from a week ago. So tonight, from clinton, a change of tone, and a direct challenge to sanders on who claims the mantle of most progressive. Lets get the view from both camps starting with nbcs andrea mitchell. Andrea . Reporter good evening, lester. Not only is it going into the debate, does the new poll show Bernie Sanders is ahead of Hillary Clinton here in New Hampshire, but he has a slight lead among women. And a giant lead with young people. As Hillary Clinton prepares for tonights showdown, her top target, reaching young voters and women. Our new nbc news wall street journal maris poll showing clinton losing the youth vote to sanders by a whopping 22 . Among women, she trails by 4 . And young women, 29 . Clinton is noticeably toning down those sharp edges she showed in iowa. I will stand up and fight for you every single day of this Campaign Reporter showing her softer, more reflective side in New Hampshire. A rare glimpse last night. Ive had to be in public dealing with some very difficult issues. And personal issues. Reporter revealing she relies on a jesuit parables. One of her strongest moments of this campaign. She also touted her progressive credentials. I am a progressive who gets results, and i will be a progressive president that will get results. Reporter struggling to answer why she took 675,000 in speaking fees from wall street banks. Well, i dont know. Thats what they offered. Reporter her ties to wall street, attacked from Bernie Sanders, and sure to come up tonight. Andrea mitchell, nbc news, durham, New Hampshire. Im casey hunt with the sanders campaign. Rallying the troops before his oneonone debate with Hillary Clinton. I look around this beautiful room, and i sense that people here want to make a political revolution, am i right about that . Reporter tonight expect Bernie Sanders to once again go after clinton with the question, whos the most progressive . Do you think Hillary Clinton is a progressive . Some days, yes. Reporter his campaign taking to twitter. The Progressive Community was pretty united in saying, dont listen to bush. Reporter key for sanders tonight, reaching older voters. Our new poll showing the majority of New Hampshire older voters back Hillary Clinton. Sanders message is already hitting home for young people. Like these students at the university of New Hampshire. Ive got a friend in bernie reporter managing expectations is another concern for sanders. Hes so far ahead right now, if Hillary Clinton does manage to close that gap, it could still be a problem for him, even if he comes in first. Lester. Casie, thank you. Check todd is comoderating the debate on msnbc. Chuck sanders long considered the frontrunner in the New Hampshire race. Does that take any pressure off secretary clinton in this matchup tonight . You know, i dont think it does, only because of the clinton tradition here in New Hampshire. New hampshires been very good to the clinton family. Saved bill clintons candidacy in 1992. Helped extend hillarys race in 2008. I dont think necessarily it buys her time. But look, this debate is coming at a time when the two of them are having a real debate about what should the Democratic Party be. Should it be what its been . Is it the party of obama and clinton . Or does it need to go in a new direction as Bernie Sanders . Clearly an army of supporters wants to take it. Chuck, thanks very much. Tonights msnbc democratic debate kicks off live from the university of New Hampshire, comoderated by chuck, and Rachel Maddow at 9 00 eastern time. In the republican race, another new poll shows marco rubio leaping over ted cruz in New Hampshire, to take the number two spot behind frontrunner donald trump. As nbcs Hallie Jackson tells us, rubios adversaries are piling on to try to stop his rise. Reporter with momentum in New Hampshire, marco rub rubios hoping for a photo finish, drawing crowds in every shot as republican rivals take theirs. Thank you guys for being here. Reporter sparked by this slip, Rick Santorum endorsing rubio, but seeming to struggle when asked why. Can you name his top accomplishment . My feeling on marco is someone who has tremendous potential, tremendous gifts. If you look at the minority in the United States senate in a year when four years where nothing got done, its hard to say there are accomplishments. Reporter rubios competitors desperate to gain ground in new sham shire. His whole life has been around his own ambitions. Hes gifted. He can turn a phrase really well. But what has he done. The fact is, this is a guy whos only done one thing in the United States senate, that is write an amnesty bill for the immigrants. Reporter reforming the va and fighting human trafficking. We have real achievements, not just in the u. S. Senate but my time as speaker of the house and as a state legislator. Reporter rubio trying to stay above the establishment fray and so is john kasich, campaigning at concord high school. Are you the president . Yes. Did you run a negative campaign . Wouldnt it be great you could run for president just like you run for class president , where you just tell people what youre for, instead of spending your time trashing somebody else. Reporter Donald Trumps trashing everyone else, slamming all politicians in typically trump fashion. I was going to say theyre full of [ bleep ], but i wont say that. While trump still leads in New Hampshire, jeb bush is hoping for a boost with help from his mom. Barbara bush will be here tonight, appearing together on the campaign trail. Former drug company ceo who some have called the most hated in america provoked a lot of anger on capitol hill today. Martin shkreli refused to testify before congress and later insulted them. Anne thompson has the details. Reporter appearing to smirk are you listening . Reporter and often inattentive. Yeah. Reporter former pharmaceutical ceo Martin Shkreli lived up to his badboy reputation appearing before congress. I intend to use the advice of my counsel, not yours. Reporter posing for pictures instead of listening. Its not funny, mr. Shkreli, people are dying, and theyre getting sicker and sicker. Reporter he declined to answer why he raised their lifesaving drugs 5,000 . Do you think you did anything wrong . On advice of counsel, i invoke my fifth amendment privilege. Reporter the 32yearold usually loves to talk. Im from the streets. Reporter but today he let his attorney speak for him. What you saw was Nervous Energy by an individual who very much would like to explain what happened. Reporter leaving the other drug Company Executives to face furious questioners. I find it repulsive what youve done. Reporter valiant under fire for jacking up prices on two heart medicines and other wellestablished drugs. Where weve made mistakes, were listening, and were changing. Reporter determined to have the last word, shkreli took to twitter calling the congressmen imbeciles. Anne thompson, nbc news, new york. Fears over the zika virus have led florida to expand its state of emergency to cover five counties. Governor rick scott said that the 12 cases discovered in florida are from infections outside the u. S. But teams are out in force in south florida spraying for the mosquitoes that carry zika. Scott is also asked the cdc for 1,000 more rapid zika test kids. We turn now to the long and bloody war in syria, and new drone video that shows the utter devastation of the city where 1 Million People lived before the war. Today the u. S. Pledged an additional 600 million to aid refugees. While those who cant get out face growing desperation. It includes those in a town outside damascus where the red cross said is getting close to getting aid to. Disturbing details of what people are facing there. Heres our chief Foreign Correspondent richard engel. Reporter theyre slowly being exterminat exterminated. Thats a syrian helicopter dropping explosives, killing one person. Danny, the activist who took this video, told us bombs rain down up to 30 times a day. He sent us another video of muhammad, a malnourished 11yearold whose father says is too weak to walk. He said these videos are the only thing he can do for his people. We see them and we cant do anything for them. They are dying in front of our eyes. Reporter the Government Cut off the city as punishment for its resistance. Syrian Opposition Forces are doing the same thing to government strongholds, in the middle. So many suffering people. This situation, this siege continues like this for a week or less, hundreds of people will die, of course. Including me. Maybe you wont see me anymore. Reporter theres no power either, so danny spoke to us by the light of a small solarpowered lamp. When was the last time you ate something . I had some olives. People are dying in the cities all around syria. And nobody remembers them. Nobody cares about them. Nobody tries anything to stop this, this disaster. Reporter which is why danny risked everything to take these images, so the world hears 5yearold crying out to her mother. Who has no medicine, food, or milk to give. Richard engel, nbc news. Horrible reality of life on the ground in syria. Lets turn to the huge methane gas leak that has affected thousands of families in a los angeles neighborhood. Tonight we have exclusive access. A scientist went up in the air to check on the air. Steve patterson was with him. Reporter it is the countrys invisible disaster, a plume of methane gas streaming into the atmosphere. Seen here in infa red pouring out of a natural gas well above the community of porter ranch. The amount of methane spewing out is impossible to measure from the ground. This is one of our biggest leaks. Were here to measure it. Reporter to gather the data, you have to fly into it. Scientist dr. Steven connelly in a specially outfitted plane to get data. The data estimates more than 200 Million Pounds of methane have poured out. Thats as much Greenhouse Gas emitted by nearly half a million cars each year. Its 20 or 30 times as large as the next biggest one that weve seen. Reporter that realization in the air led to a hundred days of heart ache on the ground. David and his daughter are among 5,000 families living in temporary housing. Walking in the community, even for five or ten minutes, to walk my dog, i couldnt breathe. Reporter he said the rate of the methane has significantly slowed. They say the reservoir will be drained, well capped by the end of the month. Were working really hard and safely to stop this situation and bring them home. Little comfort for families waiting to go home, as the invisible threat hangs in the air. Steve patterson, nbc news, over porter ranch, california. Still ahead here tonight, protecting the shub. We flies with the eyes in the sky and go inside the fbi nerve center tasked with securing the biggest sporting event of the year. 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It is the biggest sports event of the year, and now the super bowl is also one of the countrys largest security operations. The San Francisco bay area gets set to host the game, dozens of Law Enforcement agencies are gearing up. National correspondent Miguel Almaguer shows us how theyre securing the city by land, sea and air. Reporter with more than 1 Million People pouring into San Francisco for the super bowl, the only thing bigger than the game may be security. The fbi leading 60 agencies on the ground, in the air and at sea. This is by far the most significant security presence weve had at any event in the bay area for sure. Reporter with bombsniffing dogs, xray machines, and Sharp Shooters positioned on rooftops, surveillance on the ground is also key. The bay area is wired, cameras, hightech centers and video feeds are recording hundreds of images every second on streets just like this one. Much of that surveillance is being beamed right back into one room. This is the fbis Central Command center, where they quarterback the Law Enforcement bling. The bad guys have to get lucky once. We have to get lucky every day. Reporter this year air teams face unique challenges. Levi stadium is 45 miles from San Francisco. Theyre watching every bridge and major roadway for anything unusual. On game day, air space will be restricted, but not for blackhawks like these flying in tandem, taking part in an aerial ballet that sincs with folks in the bay. Reporter patrolling up to 200 nautical miles out to sea. Our job is to use our training and experience and notice when things may not be 100 what they should be. Reporter the threat could come from anywhere. Its not just the super bowl that makes the bay area a security concern. Its also a status as a symbolic american city. A city where all eyes will soon be on the super bowl. But not everyone will be watching the game. Miguel almaguer, nbc news, San Francisco. 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Investigators did find explosive residue in the aftermath, but if it was a bomb, no terrorist group has claimed responsibility yet. More air bag recalls, millions more. Honda says another 2. 25 millionaire bags made by takata will have to be replaced in certain honda and acura models. Another air bag manufacturer announced its own recall involving potential air bag problems in up to 5 million honda, fiat, chrysler and mercedes models. A sad note to report in the music world. Maurice white died. He started the band in the late 1960s, and the group went on to sell more than 90 million albums worldwide. The group won six Grammy Awards and inducted in the rock n roll hall of fame in 2000. White battled parkinsons disease for more than two decades. He was 74 years old. Up next here tonight, you dont have to wait for the super bowl to see every day you read headlines about businesses being hacked and intellectual property being stolen. 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Ask your rheumatologist about humira. Humira. This is my body of proof finally tonight, for many theyre the most entertaining part of the super bowl. The commercials. But if you dont want to wait until sunday to see them, Nbcs Joe Fryer offers us an early peek. Reporter the kickoff might be three days away, but the Super Bowl Ad game is already in the corner. Once again, Many Companies are releasing their commercials before the big game, hoping to generate days of buzz instead of just hours, even if many fans would rather wait. Mr. Tyler . Your skittles portrait. Dream on higher. Dream on reporter this years trend, celebrities. Liam neeson is hawking tvs, and Christopher Walken is a car salesman along with Serena Williams and ryan reynolds, and ryan reynolds. Oh, in my face this will be the celebrity bowl. Youll probably see north of 75 of the ads at this point having some sort of celebrity element. Reporter perhaps the only thing that can top star power is puppy power, the adorable and the bizarre. This year a 30second super bowl spot is going for as much as 5 million, an alltime high. Advertisers are cranking up the comedy. Miss monroe, eat a snickers. Why . You get a little cranky when youre hung hungry. Better . Much better. My fellow americans reporter an early favorite this bud light political spoof. Just wait until you see our caucus. Reporter dont worry, though, many ads still havent been released, leaving plenty of room for game day surprises. Joe fryer, nbc news. Thats going to do it for us on a thursday night. Im lester holt. For all of us at nbc news, thank you for watching, and good night. New video. Celine dion talking publicly for the first time about her husbands death. Now on extra. Celines emotional tribute to the man who made her a superstar. I love you, so much. Her now grown son by her side. How the family said farewell to renee. Terror for taylor swift. Cops detain a man in her driveway. What he was caught doing. Friends cast reunited, taking on the craziest rumors. Did you all sign contracts saying that you wouldnt sleep with each other . Then, mario sitting down with george and channing. Who is clooney calling a bit of an idiot . I think thats a fair assessment. And what on earth is tatum talking about . Your, you know, butt starts getting a little tight. The alist interviews dont stop there. Im sitting down with my girl ellen. Valentines day plans . You better get me something. Ive gotta raji p. Henson. Plus, katy perry and orlando bloom. New pics, new clues their romance is on. And a. J. s in San Francisco wi