Developing news tonight. Damage control over the skyrocketing cost of lifesaving medicine. A big pharma ceo on the hot seat refusing to cut the price. Tonight a big star is cutting ties with the company. Prejudice and paranoia. Hillary clinton unloads in a blistering takedown of donald trump supports racist and trump on immigration suddenly embracing the jeb bush plan he once denounced. Taking aim. Florida in the crosshairs as a gathering storm closing in. Al roker is here. Aftershocks and a soaring toll in the quake zone. A desperate search in the rubble to find any signs of life. And burkini ban. As women are forced to take off clothes, fined for wearing too much. A battle at the beach from nbc news World Headquarters in new york, this is nbc nightly news with lester holt. Good evening. No apologies and no price cut offered today from the woman in the middle of a growing firestorm over the soaring cost of prnlle lifesaving epipens. Up in 400 in recent years. The ceo of the company that makes them spoke out today on our Sister Network cnbc to defend a series of emergency injectors that millions with serious allergies keep at the ready. But with her own salary under fire, the company did offer consumers some relief today, but even that is being met with some skepticism. Tonight nbcs tom costello has been following the story for us and has the latest. Reporter she may be the most unpopular ceo in America Today on the cnbc hot seat. Heather bresh runs Mylan Pharmaceuticals from 90 to 600 over ten years. Meanwhile her compensation has also skyrocketed. Youre making 18 million a year. Do you understand how that looks . I understand better than anyone that facts are inconvenient to headlines. Reporter after days of intense public backlash, the company today said its offering more discounts and 300 coupons for some patients, but no price cut. Just cancel the price increase. Why cant you do that . Reporter i have t in the brand pharmaceutical market this isnt an epipen issue, this isnt a mylan issue, this is a health care issue. Reporter she calls the Health Care System broken with too many middle men demanding a cut but some Health Care Experts said without a price cut the companys coupons are just a pr move since the cost only shifts to insurance companies. What that does is that just ends up increasing costs to the system which is then reflected in the and overall increase in Health Care Spending are rt in North Carolina tracy bush has the receipts of skyrocketing epipen prices her insurance thankfully paid for her son devin. Plain and simply, if the price of the epipen was affordable to begin with, it wouldnt matter if someone has insurance or not. Reporter actress Sarah Jessica parker who promoted epipens because her own son needs one cut ties with the company. Are the price hikes for mylan done . To continue to run a business, and were going to continue to meet the smi and demand of whats out there. Reporter she is the daughter of West Virginia senator democrat joel manchin. Today he issued a statement saying he is also concerned about skyrocketing drug prices and he wants to find ways to lower them and improve the system as well. Tom costello, thank you. To president ial politics now and a day of explosive rhetoric on the campaign trail. Hillary clinton unloading on donald groups mainstream and helping the radical fringe take over the republican party. Meantime, trump blasted clinton, calling her a bigot. Trump also making headlines for a major shift on immigration. We have it all covered starting with andrea mitchell. It is getting heated. Indeed it is. After a week of playing defense Hillary Clinton arguing tonight that donald trump can soften his rhetoric and stick to a script but that hes helping a radal advocating racist ideas. Tonight Hillary Clinton going farther than ever before, painting donald trump as an extremist. Dark, disturbing, sinister. From the start, donald trump has built his campaign on prejudice and paranoia. Reporter going after trump point by point, his birther past. Why doesnt he show his birth certificate . He promoted the racist lie that president obama is not really an american reporter his retweets of White Supremacists or theories of clintons health. His latest paranoid fever dream is about my health. And all i can say is, donald, dream on. Reporter and now clinton blasting trump for hiring steve bannon, head of breitbart, a conservative website linked to the new alternative right as campaign ceo. In her speech citing breitbart headlines. Birth control makes women unattractive and crazy. A has effectively taken over the republican party. Reporter trump firing back even before she started speaking. When democratic policies fail, they are left with only this one tired argument. Youre racist. Reporter clintons speech a welcome indictment say altright critics. Its a movement thats racist. Its a move thats antisemitic, and a movement thats been gaining a foothold in through breitbart news. Reporter the speech also a chance for clinton to turn the page after a week of attacks. Charges of special access tore Clinton Foundation donors when she was secretary of state. I know theres a lot of smoke and theres no fire. Reporter tonight clinton trying to make trump the target instead of her. Andrea mitchell, nbc news, new york. Im katy tur in new york where 25 floors up donald trump was working to convince voters he isnt a racist. Peo reporter his hardline immigration rhetoric proving unpopular, trump is polling his position with an audience at this fox news town hall. Call it applauseometer politics. Do we throw them out or try to work with them . Reporter the result, trumps plan now sounds strikingly like someone elses. I called for a path to legal status, not a path to citizenship. They work, they pay taxes. Theyll pay back taxes. They have to pay taxes. Theres no amnesty as such. Theres no amnesty. But we work with them. Reporter a stunning flip. Trump now agreeing with jeb bush who he sharply criticized as weak on immigration. Conservatives left with whiplash. Can you imagine if youre jeb bush today . Who knew . Im sorry. Reporter jeb bush flabbergasted on wabc all things that donald trump railed against he seems to be morphing into. Its kind of disturbing. Reporter but will it matter . There will be some shortterm noise about it. But i dont see this blowing up in his face the way some are predicting. Reporter today clinton intensified her criticism as trump took his name calling to new extremes. Hillary clinton is a bigot who sees people of color reporter trump repeated that claim again in an interview tonight. It seems that he feels favor. From a political storm to the real thing, were keeping an eye on one gathering and getting even closer to the u. S. A potential tropical threat for the southeast. Al roker is tracking the storm. Al, whats the latest . Lester, this thing hasnt turned into a Tropical Storm yet but we do look to see this invest area 99l. 70 in the next five days. Both theur United States models track this thing through the bahamas tomorrow. By sunday both bring it across southern florida where an increasing threat for heavy rain. The european model intensifies it as it gets into this 90degree water of the gulf, keeps it hugging the western coast of florida. But what we are looking at one way or the other, we know well be seeing a big, big mainmaker, anywhere from 5 to 7 inches, locally could be even more. It hasnt formed yet. Closely. I know youll update tomorrow on today. The heart wrenching drama in central italy where the death toll has sored to 150. Big aftershocks are jarring already fragile rubble and fragile nerves as rescuers refuse to abandon hope in their relentless dig for survivors. Lets get the latest from bill neely. Reporter still digging, still hoping for a mirking ale after 48 hours, but the ground i shaking, too. Were still seeing an enormous aftershock here. One of more than 400. The dust still rising here. It sent rescuers running and ambulances scrambling. But still they dig, and heres why. After hearing a voice in the rubble, rescuers find a little girl and free her trapped legs. Julia is bewildered but alive after 16 hours buried. Clinging to her rescuer uninjured. Musical girl, they shout. Other children didnt make it. Officers sift through their belongings. They knew them. They saved the live of two children but heard noers the rubble he couldnt help. Theres anger here, probing why this school collapsed in spite of a Million Dollar spent to make it earthquake proof. Most of the apartment blocks in this neighborhood have simply crumbled. By law, they should have been built to withstand the earthquakes that are so common here, but someone didnt do that. Amatrice was voted one of italys most beautiful towns. Some of its buildings 600 years old. Now its a ruin. Though some of these places are little more than dust already. And there have been more big after shocks here in the last few hours. One rescuer told me they are not giving up hope of finding survivors in the rubble. They found one survivor in a previous earthquake after three days, and they are here in their thousands to try to do the same right here. You have to admire their bravery. All right, thank you, bill late word of a shocking murder mystery unfolding tonight in mississippi. Two catholic nuns found dead in a home, victims of an apparent stabbing attack. Now police are on the hunt for a suspect or suspects. Nbcs Gabe Gutierrez has more. Reporter tonight investigators in durant, mississippi, are rushing to find out who killed two catholic nuns in their homes. Both Nurse Practitioners who help the poor. Sister Paula Merrill from kentucky and here in a video from the local archdiocese. Margaret and i have worked together for many years. We just see patients and do what needs to be done. Reporter an officer found them this morning when they didnt report to work as usual at the local archdiocese tells nbc news there were signs of a breakin. They were stabbed and their car is missing. Its not clear if their religious work has anything to do with the killing. We make a difference in peoples know what that difference is. Reporter a priest who knew them saying these were the two sweetest sisters you could imagine. Its so senseless. Tonight a community is on edge and asking for prayers as Police Search for a killer or killers. Gabe gutierrez, nbc news. Drastic measures are being taken in montana tonight to stop a deadly invader thats killing thousands of fish. Officials have shut down nearly 200 miles of the popular Yellowstone River, as our joe fryer explains,s that a big recreation is a 6 billion a year industry. Reporter it may look tranquil, this quiet ribbon of the Yellowstone River winding through montana, but not to locals. Its really unnerving, actually. You would think there would be some peace to it, but theres not. Reporter this a typically fly fishing destination, but these days the only activity comes from scientists combing a river thats littered with dying whitefish. The culprit, a parasite that causes a in fish. I saw that nothing looked as it should, and i knew right away it was a significant infection. Reporter state wildlife officials have now closed down a stretch of the river thats 180 miles long. No boating, no fishing, no rafting. The parasite wont hurt humans, but they want to make sure it doesnt spread to other streams or move south to Yellowstone National park. The research thats been done appears that fish can survive the develop resistance through time. Reporter the timing is horrible. For fishing guides and people in the rafting business and people that make 100 of their living off the river, its traumatic. Reporter just visit the dan bailey fly firning shop in livingston. We should have so much noise in here. Its so quiet, its scary. Reporter you can hear the buzz of a fluorescent light in a store thats nearly as empty as the river. I mean, last friday was the day of the shutdown, the next day our business was cut in half. Reporter now business is a fraction of that and its closure will last. A lonely river beneath a big sky. Still ahead here tonight, bathing suit backlash. The growing outrage over a ban on socalled burkinis for muslim women. One beach goer forced to publicly strip. Also the secret to the colonels. Were back now with a controversy exploding around the world over socalled burkinis, the specially designed bathing suits worn by some muslim women at beaches and pools have been banned by several towns in france. Now that countrys Supreme Court is about to weigh in on whether those laws are legal. Nbcs Kelly Cobiella takes us inside the uproar. Reporter french beaches are famous for sun and a lot of skin, strip. Four armed officers standing over her. Then fined. Shes muslim, accused of violating a new law against socalled burkini. A bicciny that is more like a burqa. It was part of integration. It was part of combining the cultures. Reporter after the attacks in nice, mayors of at least 15 towns banned the to islamic extremism. A symbol of enslavement, the french Prime Minister says. The ban has sparked protests. Online this tweet. You should be weeping, france. And this, a picture of Jacques Cousteau fully covered. In this secular country where its illegal to wear crosses in pools and veils over faces, most support the burkini ban. You come to france, says. But for some its political. There are more important things like education and womens rights, the mayor of paris says. By the weekend, covered skin could be back in. Frances highest court will rule in the next 48 hours whether to let women wear what they want. Kelly cobiella, nbc news, london. Were back in a moment with more hot water for olympic an update on the racist hack attack we told you about last night against snl star leslie jones. The department of Homeland Security tells nbc news it is investigating the hack which included racist memes, exposed license and passport photos. Tonight officials in rio say olympic swimmer ryan lochte will be summoned to appear before a brazilian judge in response to the bathroom vandalism case in which lochte is accused of making a false statement to police claiming he and three fellow swimmers were held up in an armed robbery. Lochte has apologized telling nbc news he overexaggerated the story. As one of the worlds most closely kfc has kept Colonel Sanders chicken recipe close to the vest but as a Chicago Tribune reporter found out he says the nephew may have cracked the code revealing the handwritten recipe while combing through the familys cookbook. The main secret ingredient, white pepper. But after realizing he may have blown the lid off the secret, the colonels nephew says the recipe coulde legit but he cant say for sure. When we come back, its the Little Things in life. A visit to a very small town hoping for big things in the they say everything is bigger in texas, but this town is the exception. For decades, jobs have left along with many resident. Now the towns in danger of going under, but our harry smith explains the citys banking on a big comeback by thinking smaller. Reporter out on the high plains of west texas, the town of spur looks like it lost its giddyup a long time ago. But lately a number of started rolling in. How exciting reporter this woman came from south carolina. Where can i live legally in a tiny house. Spur, texas, popped up. Reporter spur has declared itself the tiny house capital of america. Vacant lots, 500 bucks. Bought it sight unseen. Who could say no . Reporter the Tiny House Movement is a thing. The belief, getting small means you can live large. This is liberating. You have everythin more. Reporter this is gorgeous. Thank you. Reporter but most towns want nothing to do with tiny houses. Pantrys on this side. Reporter theres eight to nine inches to spare on either side. And folks in spur werent so sure about it either. What kind of people . What are we talking about here . You know . Nudists, anarchists . What . Reporter welcoming tiny houses to spur reinvent yourself. Reporter tiny houses go for about 30 grand and up. Five are complete now. And they think there could be 20 done by the end of the year. Youre the zoning guy. Yes, sir. Reporter have you ever been this busy . No, sir. Reporter a College Professor plans to teach online from her tiny house. She has no regrets about leaving her big house and old life behind. You have a tiny house, you have a tiny dog. You have a tiny car. So what does that say . I want to live all the way around, right . Reporter indeed. In her little house on the prairie. Harry smith, nbc news, spur, texas. Thats going to do it for us on a thursday night. Im lester holt. For all of us at nbc news, thank you for watching, and good