Weeks has reached a dramatic conclusion. The woods of oregon, the antigovernment protesters occupying a wiwilife refuge have surrendered to the fbj. Tens of thousands listened to it play out. Joe fryer is in oregon and starts us off with late details. Reporter tense moments on the 41st day of the wildlife refuge occupation, all of it broadcast live onlili. After three holdouts turn themsmsves in, the fourth and final og pier, david fry, refuses to surrender. Im a free man, i will die a free man. Reporter before finally peaceful lip giving up. If everybody says hallelujah, ill come out. When they said hallelujah, he came out. Reporter the fbi tens of thousands were liststing. Lets be clear. Armed occupation of federal property is a crime. It is not a peaceful protest. Those negotiating with the group reverend franklin graham, son of billy gram, and michelle fiori. Never lost faith. I came here with a mission, and the mission was accomplished. Reporter armed militas took over the wildlife refuge nearly six weeks ago protesting federal ownership of western lands. One was shot and killed in a confrontation with law enforcement, and others were arrested. Last night clive bundy was taken into custody after landing at the portland airport. He was not part of the occupapaon, rather his arrest is from a standoff with armed bundy joins his sons behind bars. The occupation is over. The refuge will still be closed for weeks. The sheriff calls it a crime, the fbi said it must be searched for explosives. In all, 25 people linked to the occupation have now been indicted on federal felony charges. Lester . Joe fryer in oregon, thank you. A major endorsement for Hillary Clinton is spotlighting the critical battle under way for africanamerican votes in South Carolina. A february 27th democratic primary there will be bern i sanders first cast in the south, and before a large number of black voters. Today clinton, who polls show hold a substantial lead among black voters got an important shot in the arm from a civil rights icon, who to sanders delivered just a shot. Nbcs Kristen Welker has details. Reporter as Hillary Clinton and Bernie Sanders prepare to face off in there are already fireworks. Theres no one else better to be prepared to be president of the United States of america than hillary clton. Reporter the influential political arm backing clinton today. It was congressman john lewis who delivered a major blow to sanders, questioning how active he was in the civil rights movement. I never saw him. I never met him. I was involved in the sitins, the freedom ride, but i met president clinton. Reporter the sanders campaign, bernie is a great admirer of lewis. Releasing this endorsement video featuring the young daughter of eric police put him in a choke hold in 2014. To go up against the criminal justice system. Thats why im for bernie. Reporter all underscoriri the african vote, like South Carolina, where clinton leads sanders africanamericans 74 to 17 . Sanders, his complicated relationship with president obama, on display during an interview with nbcs kasi hunt where they discussed the gap. You dont think president obama has successfully closed that gap . No, i dont. I think hes made the effort. When i talk about a Political Revolution is bringing millions and millions of people into the political process. Reporter the Clinton Campaign firing back. Considering how little senator sanders has to show for his 25 years in congress, the idea that he would be ctures to president obama is absurd. Reporter our latestoll shows president obamas Approval Rating among africanamericans in South Carolina is at 92 . So expect secretary clinton to again embrace him tonight in what could be the most contentious debate lester . Kristen, thank you. The republicans face the dems, a week from saturday. Tonight much of the fight to take down the highflying donald trump is taking place on the ground there. Ted cruz who won the first contest in iowa is trying to bounce back from his loss this week in New Hampshire with an aggressive ground game and a direct attack on trumps conservative credentials. With more, heres hallie jackson. Reporter matt wells quit his sales job in iowa to sell ted cruz instead alongside 10,000 volunteers in South Carolina. I can get another job when i get back. I cant get another country. Its a risky move, quitting your job ill go back to iowa and go back to work and all that. Try to help ted win here first. Reporter wells is one of nearly 10,000 volunteers here in South Carolina, making some 25,000 phone calls a day. Part of the depending on to topple donald trump here, like he did in iowa. The state of South Carolina, i dont think people are interested in someone, a republican candidate whos pushed partial birth abortion, who wont defend marriage. Reporter cruzs strategy, paint trump as too liberal, with more ads like this one on the way. He pretends to be a republican. Reporter for his part, trump seems to be playing a more positive political game than before. Its going to be such an unbelievable week and a half. Reporter but in the more mannerly south, his more colorful language may be a big turnoff. He gets the nomination theyre going to sue his [ bleep ] off. Reporter as the focus group found. Its crass. Its a leading president ial candidate saying profanity from a stage. Reporter marco bio and jeb bush, meanwhile, taking shots at the frontrunner how do you think donald trump going to washington will solve jeb bush has no Foreign Policy experience, period. Reporter trying to prove South Carolina isnt simply a twoman fight. Underscoringnghat point, a new cruz ad slamming rubio for being nothing more than a pretty face. This race getting roughandtumble already, with nasty new robocalls. In a new twist, jeb bush is getting backup on the trail from his brother, former president george w. Bush making his Campaign Debut on monday. Lester . Hallie, jackson, thank you. Its always there, lurking, and now the dreaded polar v vtex is heading south, bringing with it the coldest air of the season for tens of millions of us. Al roker joins us with the details. Yeah, lester, it will be potentially deadly weather coming in. The polar vortex is already there, but it will shift over to the northern atlantic. The jet stream dips to the south. That means that cold air spills south of the canadian border, into the northeast, and the midwest, bringing some of our colder temperatures bismarck tomorrow will feel like 7, minus 7 in minneapolis. 13 in cleveland. As we get into saturday morning, youll see those temperatures Single Digits and below. And we bottom out sunday morning, records possible in boston with minus 5, 2 in new york city, 4 in rochester, 1 in pittsburgh, roanoke 10. You get out west, its going to feel like a different season. From seattle all the way to roswell and down to san diego, it will actually feel like temperatures in april and may. So weve got two Different Countries depending on where you live. Al, thanks. Good to have you here. The International Olympic committee tried to reassure the world today that all measures are being taken to fight the zika virus ahead of the games in rio. But u. S. Officials are taking their own precautions as we hear from a star athlete casting doubt on whether shell compete. The outbreak has led to an emergency appeal from top u. S. As our rehema ellis reports. Reporter puerto rico could be the next hot spot for the zika virus, warns the cdc, testifying before the senate today. At some point we may well see tens or hundreds of thousands of zika infections in puerto rico. Reporter this news as the u. S. Olympic committee announced its hiring two Infectious Disease experts to advise the 500 athletes hoping to compete in brazil. Including soccer star hope solo. If i had to decide today, i would not go. Fortunately, the summer olympics are about six months away. I think we have time to get our doubts and questions answered. Reporter the soccer teams will compete in areas even more vulnerable to zika than rio. One is near the amazon rain forest. Another in an area where the number of zika cases are especially high. I dont think soccer being so close where theres more mosquitoes. I take my health very seriously. We all do. Reporter new research has found more evidence linking zika to babies born with microcephalus. Competed while pregnant, there were five during the london games in 2012, including gold medalest kerry walsh jennings. Well be waiting to hear what steps will be taken to makeure everythings safe and secure. Reporter with women making up half countdown to the olympics is on. Rehema ellis, nbc news, new york. A California Utility Company now says its finally stopped the leak from a ruptured well that has been spewing natural gas into the air near los angeles. Making people sick and forcing thousands of families from their homes i i porter ranch. Its been leaking for nearly four months. Invisible to the naked eye, but the giant cloud apparent in temporary fix, but if it holds, it will be cemented closed. They face a lawsuit over the investigations in all this. Nato is intervening in the massive refugee crisis sparked by the war in syria. Its deploying patrol boats to intercept migrant smugglers. As many flee syria, others are trapped, including hundreds of thousands in syrias largest city. Nbcs chief foreign correspondent, richard engel, shows us the desperation inside aleppo. Reporter the Syrian Regime has been fighting rebels in aleppo for years now. But an air strike is clearing the way. First syrian troops are advancing and destroying the city in the process. Activists in the White Helmets dig through the rubble for survivors. They provided us with this footage to show the world what is happening in aleppo. One of the volunteers told us by skype that fall is near. We are so worried, because if we lose aleppo, we lose all the war. Reporter the russian involvement changes the game . Yes. Absolutely. It changes everything. Reporter aiding, he says, 70,000 people already escaping aleppo in the last few weeks. Panic is spreading in aleppo that the regime plans to starve the city into submission. Its a tactic theyve used in other places. Thats why we are sending this to you and all the world. We need help. Of help do you need . What are you looking for . Now, we need just to stop the russians. Reporter the russians say they are bombing isis targets in aleppo, but ismael excuse. We dont have any isis. They just helping the forces and killing us. Reporter the u. N. Said 300,000 people inside aleppo and fears an unprecedented wave of refugees may be leaving the city in the next few days. Refugee crisis far worse. Richard engel, nbc news, new york. There is a lot tonight. Still aheaea new details about that nightmare cruise. Well hear firsthand from those onboard it. 30foot waves battered the ship. One newlywed said she feared she would die on her honeymoon. They could be the first astronauts on mars, and theres if you have postmenopausal osteoporosis and a high risk for fracture. I can tell you prolia is proven to help protect bones from fracture. But the real proof . My doctor said prolia helped my bones get stronger. Are your bones getting stronger . Do not take prolia if you have low blood calcium, are pregnant, are allergic to it, or take xgeva. Serious allergic reactions, such as low blood pressure; tightness; face, lip, or tongue swelling; rash, itching or hives have happened in people taking prolia. Tell your doctor about ntal problems, as severe jaw bone problems may happen, or new or unusual pain in your hip, groin or thigh, as unusual thigh bone fractures have occurred. Prolia can cause serious side effects, including low blood calcium, serious infections. Which could require hospitalization; skin problems; and severe bone, joint or muscle pain. Only prolia helps strengthen and protect bones with 2 shots a year. I have proof prolia works for me. Can it work for you . Ask your doctor about prolia today. Caring for someone with alzheimers means i am a lot of things. I am her best friend. I am her ally. So i asked about adding oncedaily namenda xr to her Current Treatment for moderate to severe alzheimers. It works differently. When added to another alzheimers treatment, it may improve overall function and cognition. And may slow the worsening of symptoms for a while. It shouldnt be taken by anyone allergic to memantine, or whos had a bad reaction to namenda xr or its ingredients. Before starting treatment, tell their doctor if they have, or ever had, a seizure disorder, difficulty passing urine, liveve kidney or bladder problems, and about medications theyre taking. Certain medications, changes in diet, or medical conditions may affect the amount of namenda xr in the body and may increase side effects. The most common side effects are headache, diarrhea, and dizziness. All my life, shes been there for me. Now i am giving back. Ask their doctor about oncedaily namenda xr we are back now, with the passengers thankful to be back on dry land on what one called the cruise from hell. The ship rocked by a powerful storm with Hurricane Force winds and 30foot waves. Water rushing inside. Many wondering why the ship set sail with that storm coming in the first place. Heres the details. Reporter passenenrs describe it as t trifying. The chaotic hours, the anthem of the seas sailed into the middle of a massive storm. I thought im going to die. Im going to be drowning in the ocn. It was very scary. Reporter lee wright was on her honeymoon. Kyle leveque was withh his mom. Absolutely. I think 5,000 peoeoe lives w we at risk. Storm became worse than predicted. Two days before the cruise even started, the National Weather service predicted waves as high as 31 feet. In the same area anthem battled the storm. This was a system that was well forecast days in advance. There were even hurricane Wind Warnings out the day that the cruise ship left for the area where they hit the hurricaneforce winds. Reporter passengers say the ship felt like it was tilting side to side in Hurricane Force winds. Waves crashing as high as the fifth deck. Inside, passengers scrambled for cover amid shattered glass and flying furniture. One of the scariest day of my entire life. Reporter tonight the ntsb is part of the investigation into what happened, and the coast guard reports the ship needs more repairs before it can sail again. Royal caribbean said anthem is scheduled to cruise the same waters starting saturday, when theres a possibility of yet another storm. With the 4500 toward a future cruise, few regret this vacation is over. Im grateful im alive. Reporter nbc news, new jersey. When we come back, its taken a century, but one of einsteins famous theories has finally been proven right. toilet flush if you need an opioid to manage your chronic pain, you may be sooo constipated it feels like everyone can go. Except you. Tried many things . Still struggling to find relief . You may have opioidinduced constipation, oic. Its different and may need a different approach. Opioids block pain signalsls but can also block activity in the bowel. Is slowingngour insides to a crawl. Longing for a change . Have the conversation with your doctor about oic, and ask about prescription treatment options. Made on behalf of those living with chronic pain and struggling with oic. You cant predict. The market. But at t. Rowe price, we can help guide your investments through gogo times and bad. For over 75 years, our clients have relied on us to bring our best thinking to their investments so in a variety of market conditions. You can feel confident. In our experience. Call a t. Rowe price retirement specialist or your advisor. To see how we can help make the most of your retirement savings. T. Rowe price. Invest with confidence. What if one piece of kale could protect you from diabetes . What if one situp could prevent Heart Disease . One. But there is one step you can take to help prevent another serious disease. Pneumococcal pneumonia. If you are 50 or older, one dose of the prevnar 13 vaccine can help protect you from pneumococcal pneumonia, an illness that can cause coughing, chest pain, difficulty breathing, and may even put you in the hospital. Even if you have already been vaccinated with another pneumonia vaccine, prevnar 13 may help provide additional protection. Prevnar 13 is used in adults 50 and older to help prevent infections from 13 strains of the bacteria that cause pneumococcal pneumonia. You should not receive prevnar 13 if you have had a severe allergic reaction to the vaccine or its ingredients. If you have a weakened immune system, you may have a lower response to the vaccine. Common side effects were pain, redness or swelling at the injection site, limited arm movement, fatigue, headache, muscle or joint pain, less appetite, chills, or rash. Get this one done. Ask your doctor or pharmacist you donon see this every day, a nicotine fix right in the middle of a hearing. Duncan connor took a puff off a vaporizer to ptest a measure that would ban it on planes. He said theres nothing toxic about the vapor. The congresswoman next to him waving it away didnt seem to appreciate it. Titanic is getting a sequel. Its debut is being pushed back from this year to 2018. An australian tycoon commissioned a replica over century after the original sank. Have upgrades including more lifeboats. A major announcement today confirming something einstein predicted a century ago. Scientists have detected navigational waves ripiping across the iverse, when two black holes collide to form one. Think of it like the Ripple Effect of spreading water when you drop a rock. Except these collisions so monstrous they can shake the fabric of spacetime. Its a very big deal, or so ive been deal. When we come back, suiting up with nasas next generation. Could become the First Americans to set foot on m at safelite, w wknow how busy your life can be. No is mom didnt have time to worry about a cracked windshield. So she scheduled at safelite. Com and with safelites exclusive on my way text she knew exactly when id be there. Hi, steve with safelite. Thanks for your text i replaced her windshield. And she didnt miss a single shot howd ya do . We won nicece that another safelite advantage. Thank you so much team sing safelite repair, safelite replace. Covergirl makes flawless as easy as. One. Tru. Three. With new trublend primer preps and smooths skin and trublend makeup blends flawlessly plus new trublend blush and bronzer from easy breezy beautiful covergirl. Woman its been a journey to get where i am. And i didnt get h he alone. There were people who listened along the way. People who gave me options. Kept me on track. And through it all, my retirement never got left behind. So today, im prepared for anything we may want tomorrow to be. Every someday needs a plan. With the pain and swelling of my moderate to severe rheumatoid arthritis. Ordinary objects often seemed. Intimidating. Doing something simple. Meant enduring a lot of pain. If ra is changing your view of everyday things orencia may help. Orencia works differently by targeting a source of ra early in the inflammation process. For many, orencia provides longterm relief of ra symptoms. Its helped new ra patients and those not helped enough by other treatments. Do not take orencia with another biologic medicine for ra due to an increased risk of serious infecon. Serious side effects can occur including fatal infections. Cases of lymphoma and lung cancer have been reported. Tell your doctor if youre prone to or have any infection like an open sore, the flu, or a history of copd, a chronic lung disease. Orencia may worsen your copd. You need. Ask your doctor about orencia. Orencia. See your ra in a difrent way. A domed practice facility, last week. Learn what workers had to do to fix it. And, Lawmakers Debate the bathroom bill for students in south dakota. And. The teen accused of shooting a Sioux City Police officer faces a judge for the first time. First wx boxes finally tonight, a help wanted sign of sorts, getting an astronomical number of applicants. Nasa is hiring its next generation of astronauts, the first new class in four years. And some could ultimately be bound for mars. Nbcs tom costello has more from Johnson Space center in houston. Reporter for nearly 60 years, theyve been americas heroes. Thats one small for man reporter the men right stuff. Now nasas next generation is suiting up. Jessica mei, ph. D. In marine biology, astronaut class of 2013. In your dream world, do you think about what kind of a mission you wouou love . I think i would like to go back to the moon. That would be a great first step. Reporter today shes in the water training for a mission to the space station. Its one of the biggest indoor pools in the world, the equivalent of 60 olympic pools, deep enough to hold 6 million gallons of water,very new astronaut will spend considerable time here getting wet. Im theheirst person to b balone on an entire anet. Reporter the movie martian, a real mars mission could be 20 years away. The next class of astronauts, minimum requirements, a bachelors degree in math, science or experience or a military background. Communication skills, to be able to successfully work on a team, both a leader and follower. Reporter a mars mission could last two to three years. Would you want to go camping with somebody you cant get along with, spend a week in the woods with them, let alone two years in a tent with those people . Reporter nasa only needs 8 to 14 new astronauts, but already more than 6,100 people have applied online. Future missions could include a rendezvous with an asteroid, even mars. We can send people there and bring them back safely, i would be up for it. Reporter two to three years, far from home, for some the stuff dreams are made of. Tom costello, nbc news, houston. That will do it thursday night. Im lester holt. For all of us at nbc news, thanks for night. Good evening and thanks for joining us. Im matt breen. And im sheila brummer. The snow may be light, but the streets ararsuffering. Were already hearing ot a handful of accidents in the sioux city metro. matt that includes a serious accident on sioux citys west side. Chief meteorologis t ron demers joins us. How much snow has fallen so far ron . Weather adlib light snow has been working its way across siouxland today and will continue into the evening and early overnight hours before coming to an end. The heavier amounts are going to end up being in eastern siouxland with maybe an inch or two of total accumulation. The snow ends tonight and then well see clearing skies sheila high winds, and heavy snow, took a heavy toll on briar cliff universitys charger dome during last weeks blizzard. Repairs continued today. matt ktivs tommie clark was in South Sioux City as the massive dome was blown back up