Himself up on board. And heartburn drug warning. Millions take them, and now doctors are sounding an alarm about some of the most popular medications on the market. Nightly news begins right now. Announcer this is nbc nightly news with lester holt reporting tonight from manchester, New Hampshire. Good evening, from a snowy manchester, the weather just one more challenge for the president ial candidates on this primary election eve as they hit 30 events across this state today, hoping to move the needle in their direction. The latest snapshot shows Bernie Sanders leading Hillary Clinton by 16 points for the decrats. Donald trump sitting on a 20point lead among republicans with a threeway mashup for second. But heres the wild card. History shows about half of New Hampshire voters are very late deciders, and with that in mind candidates on both sides are noticeably stepping up their attacks. Nbcs andrea mitchell. Shes covering the clinton campaign. Andrdr, good evening. Reporter good evening to you. Hillary and bill clinton frustrated by their inability to close the gap with Bernie Sanders, especially with young women. And they are running out of time. Im looking forward to it. I need some fuel. Reporter Hillary Clinton never thought shed be on the losing side of a gender gap, but young women are abandoning her in droves for Bernie Sanders, a yearold man. She seems a little ololfashioned for feminismsm i donon vote with my feminine femininity femininity. I vote with logical reason. Reporter today bill clinton trying to stay on message. I have to be careful what i say. Reporter b clearly unhappy about the state of the campaign. Why do you think berens argument is having an impact here . Young people are really mad and really apprehensive and they are right to be, but they should listen to a debate about what cause it had, whats the best him. Reporter do you think hes been unfair to her . Well, i think hes been inaccurate. Reporter sunday night it all boiled over. I mean, when youre making a revolution, you cant be too careful abouthe facts. Reporter and accusing sanders supporters of using sexist language. Attacks that are literally too profane often, not to mention sexist. Reporter Sanders Campaign says its disappointed. I think its unfortunate that president clinton has decided took after persony that way snig nothing bill clintonss jabs, sanders is tiredut confident. And im here today to ask your support to join with us in making that political revolution. Thank you all very much. Reporter and Hillary Clinton with Rachelle Maddow addressed reports they will shake up their staff. Were going to take stock, what works, what doesnt work. Of course, it would b b malplpctice to say okay what works, what can we do better and can do new and different that we have to pull out. Reporter tonight bernie a frontrunner. To find themselves so far behind. Andrea mitchell, nbc news, manchester. Reporter im katy tur following the trump campaign. One door. How are you doing . Im good. How are you. Reporter one voter at a time. Reporter have you decided on what youre going to support . We have not decided. Reporter campa staffer jamie peevy is making a pitch for donald trump. Im still on the edge. Reporter the candidate is trying to hold on to his commanding lead in the polls by blanketing the state, getting up close and personal with voters in four stops today. ; we have to get away from these politicians,able we have to bring sanity to this country. Reporter trumps retail politics efforts coming late in the race after an awkward sunday, barely talking to voters in a diner and meandering through an unfocused stump. What do you think so far . I think thats a bunch of garbage. Reporter here historirilly voters makeep their minds te. Usually im a a gut i itinct kind of person so still trying to figure that how the. Reporter that means second and even first place could be up as marco rubios dismal debate performance. Nobody now believes that marco rubio is prepared to be president of the united states. Reporter field trying to capitalize on rubios scripted missteps. Jeb bush and john kasich suddenly climbing in the polls. People are looking not only to understand whats in your head, but they also wanto know whats in your heart, and if all you are is scripted, im not sure that people respond to that. People will want to know what kind of leadership skills people have, rather than how good you are at turning a phrase. Reporter bush throwing snowballs and hurling insults, calling trump a loser, a liar and a whiner on twitter. Up 21 points, the state is Donald Trumps to lose. Bush knows it and so does trump. Let me tell you. Hes not going anywhere. Reporter trump takes the stage herer in jusus about halff an house, and right now this room is just about half full. New hampshire is a fiercely independent state. It is one that is known to surprise, and although donald trump is up by a lot here, i those leaving the trump rally early on sunday told me that they were going to go see john kasich. All right. Katy tur, thanks. Lets go back to marco rubio. Hes brushing off broad criticism that have saturday debate performance when he was called out for repeating the same talking point about president obama four times in the span of a few minutes. I joined him on the trail here in New Hampshire this morning where he acknowledges relative success in iowa has opened him up for attack here. Whats it like to have a big fat target on your back . Dont you feel that what i its part of the process. When you have a target it means youre doing something well. Hi, how are you. Reporter could marco rubios debate moment change all that . For the past two days its been hard to miss. Senator,ere sitting in a diner and o o tv they are talking about you. Lets dispel once a for all with this ficon that barack obama doesnt know what hes doing. Lets dispel with the fiction that barack obama doesnt know what hes doing snow repeated the same thing four times. Ill say it again. Barack obama is trying to change this country with those changes. Ill say it again. None of the things that has happened are accidents. Obamacare was not an accident. Dodd frank is not an accident. Reporter but in repeating it over and over again it played too this notion that your crititi haha, some of your opponents, at you are a bit contrived, that youre rehearsed. Thats silly, and people understand when they are running for office are going to say whatever they need to say. Chris christie has a very liberal record, right . He supported gun control. He supported planned parenthood and wrote them a personal check. He endorsed. Sonia sotomayor so if youre a candidate you dont want to talk about that. You want to figure out Something Else so thats what they will do and the media is always looking for something new and interesting to cover. For voters, 9 Republican Voters agree with what im saying. Reporter marco robot, to see a headline that you checked. Thats just part of the pros semnoz doesnt bother you . Was it your finest performance . In our website we raised more money in the first hour that have debate than all the other debates. Your opponents talk about the experience of actually being in charge of something as opposed to, you know,eing on the legislative side as a senator. What do you respond . Whats your response . That they have zero experience on Foreign Policy, none. Jeb bush has no Foreign Policy experience. Reporter how deep is your Foreign Policy . More than any of them, member of the Intelligence Committee for five years and going through some of the most Sensitive Information this government has. I have more Foreign Policy and National Security expience than everybody else on that debate stage the other night combined. Reporter your third place showing in iowa, stroro third place, has put a lot of expectations on you inn terms of Going Forward here. What does that mean in terms of what happens in New Hampshire . What is your bar . Every state is different. You have donald trump thats consistently been in first place now since june or july. Hes the clear frontrunner. Well do well here. We have a good team here. When its all said and done and the delegates are counted up well have more than half of them and well the n ninee of that i remain 100 convinced reporter conversation with marco rubio over a cup of coffee this morning. Our political director and moderator of meet the press. Chuck, youve got bill clinton on the attack, trump getting personal with voters, rubios debate performance. Are we seeing anything late in the game thats dramatically shifting the dynamic . Reporter i think whats amazing is how jumbled everything is on the republican side, and New Hampshire is no longer going to serve of as the state we thought it would. We thought it was going to be the state that would winnow this republican field. I think now because of the rubio debate performance, even if he does still finish second, his opponents all believe he has a glass jaw and want another crack at him in south carolina. Lets not lose sight of this fact, lester. Both Bernie Sanders and donald trump, have been leading in the polls here for months. They have not lost their lead. Maybe it goes up and down, and the fact of the matter is when the country is upset, New Hampshire is the first one to tell us and a sanders trumppuel victory will tell us and send us just tt message. Thats still a big deal, lester. Chuck todd tonight, thank as can you see around mere a winter storm has battered part of the east coast which is bracing for another storm that could hit as primary voters go to the polls tomorrow. Today a blizzard blasted new england with triple threat conditions. Heavy snow, strong winds and icy flooding. Cape cod and the massachusetts coast got the brunt of the storm. In c cnecticut a tour bus with at least 70 passengers rolled over. Many of them were hurt. I95 was shut down for several hours. Tonight, thousands aboard one of the biggest cruise ships in the world are heading back to port, shaken after a nightmare at sea as the ship sailed right into a powerful storm with Hurricane Force winds and 30foot waves slamming into the sides. Water rushing in and passengers running for coveve nbcs Janet Shamlian has more. E. Reporter a monster storm off the carolina coast, on a collision course with the Worlds Largest cruise ship. This was the aftermath aboard room in tatters and shattered glass everywhere after the vessel was tossed like a toy in winds matching a category 2 hurricane. My dad at one point says, you know, this ship couldld crack in half. Reporter more than 6,000 passengers and crew ordered to take cover. The crew started saturday in new jersey, scheduled to dockn florida today before continuing to the bahamas, but tonight the trip is cancelled. The vessel is returning, due back wednesday. Diane hockman said many passengers are angry. Angry becauau they feel that somebody should have known. They are angry because they feel that they have lost their special vacation. Reporter royal carribeans is promising a full refund and said in a statement while weather was unpleasant the ship remained seaworthy at all times. But with the storm forecast for days, why did the ship trial to go through this, this from an announcement on board. Yesterday turned out to be probably one of my worst days at reporter the vessel is in calm waters now, ass frustrated vacationons sail back to win the every afterrama on the high seas. Janet shamlian, nbc news. The cdc has now moved to its highest alert level over the zika outbreak, and president obama has asked congress for 1. 8 billion in emergency funding to combat the virus linked to birth defects. Also, as tom costello explains, there is growing concern ahead of this years olympic gameses in brazil. Ound zero for zika. With the rio games just six months away the u. S. Olympic committee today reiteratedcdc guidance that pregnant women and anyone who is concerned for their health might consider not going to the games in august but added we would not and will not prevent athletes from competing for their country should they qualify. Top zika experts say its a personal decision. Itssery d dficult to giviv advice to people who h he devotedhe last x number of years training for that, and the hin could do is to just give them the facts and the evidencebased information. Reporter with 4,000 babies already diagnosed with microcephaly in brazil, today the white house asked congress for nearly 2 billion to search for a vaccine and ramp up the fight. We expect with the warmer months to comom that more risk will be present, and so this is really a time where we need to scale. Reporter the cdc now says its Emergency Operations center has moved to the highest level to respond to the zika outbreak. While on the ground in south florida, a proactive push to wipe out mosquitos that could soon arrive carry the zika virus. Searchers say they still dont know whether zika can be transmitted through saliva and urine and also continue to believe Mosquito Control efforts should prevent a widespread outbreak in the u. S. Tom costello, nbc news, washington. Investigators have released potential key evidence in the over somalia, a video that they believe cap tufford the handoff of the bomb that later blasted a hole in the fuselage. Nbcs keir simmons shows us whats on the tape. Reporter the new video shows twoen cooley walking through an airplane. They appear to be airport staff, one carrying what looks like a laptop, but authorities now believe that laptop was likely a bomb, and this is the moment they hand it to an alleged suicide bomber. The result, a hole blasted in the side of a commercial airliner tuesday. The body of the alleged bomber ejectete from the plane by the explososn. Was t ts the work of peoeoe who worked at the airport . Reporter well, one of the people who works at the airpo we are investigating. Reporter investigators working with a team of americans have arrested 20 people. Some Aviation Security experts say it shows the risk from workers inside airports, even in the u. S. Enough security measures from the inside,nd i think thats a oblem, and i thinknk its something that immedia action needs to be taken on. Reporter alleged bomber was booked on a cancelled Turkish Airlines flight. He took a later plane. Had the bomb gone off later at a higher altitude, the explosion may have killed everyone on board. Keir simmons, nbc news, london. Still ahead tonight, are you one of the millions of americans who take heartburn medicine . A new stutu shows that reflux relief comes from a serious risk of a potentially lifethreatening disease. It was had a matchup of peyton with advil, youll ask what backache . What sore wrist . What headache . What bad shoulder . Advil makes pain a distant memory. Nothing works faster stronger or longer than advil what pain . Advil. Man dear mr. Danoff, my wife and i are now participating in your mutual fund. We invested in your fund to help us pay for a College Education for our son. Weve enclosed a picture of our son so that you can get a sense there are real people out here trusting you with their hardearned money. At fidelity, we dont just manage money, we manage peoples money. A heart attack doesnt care if you run everyday, or if youre young or old. No matter who you are a heart attack can happen if youve had a heart attack, a bayer aspirin regimen can help prevent another one. Be sure to talk to your doctor before you begin an aspirin regimen. Bayer aspirin. burke at farmers, weve seen almost everything, so we e ow how to cover almo anything. Even a stag pool party. party music splashing destruction splashing destruction burke and we covered it, october twentyseventh, 2014. Talk to farmers. We know a thing or two because weve seen a thihi or two. Tonight a new warning about some of the most popular prescription drugs in america, treating heartburn and acid reflux. They are now also sold over the counter. While its already known they are linked to a risk of fractures and infections, now a new study finds they can have another serious side effect. Nbcs Anne Thompson has the details. Cant afford to let heartburn get in the way . Reporter stopping heartburn is big business. Zero heartburn. Reporter sold as nexium, prilosc and prevacid more than 15 million americans shelled out more than 10 billion in 2013 for the prescription versions off these drugs cold proton pump inhibitors. Now a new study from johns drugs may increase the risk for 50 . Cleveland clinic kidney hinkel. Kim had normal kidney nunks in march and bloodwork in august showed kidney function down to 30 . Reportete kim was taking one the overthecounter versions. On a hunch the doctor had kim stop, and her kidneys improved. I was lucky it was caught early, and that we can do something about it. Reporter for overthecounter acid reducers the fda recommends they be used for 14 days and no more than three times a year. For the prescription versions, the package insert recommends for most conditions the pills be taken for up to eight weeks. Pills are not the only answer. Food is the answer. Reporter this doctor prescribes the drugs but insist his patients also avoid acidic vote like chocolate, berries and caf fine for 28 days. You can change your diet and actually heal your own body by what youre eating. Reporter makers of these drugug say they are safe and effective when used correctly. That and diet can keep stomach id where it belongs. Anne thompson, nbc news, new york. Were back in a moment with the race to rescue dozen from earthquake rubble with time running out. Your path to retirement. May not always be clear. But at t. Rowe price, we can help guide your retirement savings. For over 75 years, investors have relied on our disciplined approach to find long term valulu so wherever your Retirement Journey takes you, we can help you reach your goals. Call a t. Rowe price retirement specialist or your advisor. To see how we can help make the most of your retirement savings. T. Rowe price. This just got interesting. Why pause to take a pill . Or stop to find a bathroom . Cialis for daily use is approved to treat both erectile dysfunction and the urinary symptoms of bph, like needing to go frequently, day or night. Tell your doctor about all your medical conditions and medicines, and ask if your heart is healthy enough for sex do not take cialis if you take nitrates for chest pain, or adempas for pulmonary hypertension, as it may cause an unsafe drop in Blood Pressure. Do not drink alcohol in excess. Side effects may include headache, upset stomomh, delalad backache or muscle ache. To avoid longterm injury, get medical help right away for an erection lasting more than four hours. If you have any sudden decrease or loss in hearing or vision, or any symptoms of an allergic reaction, stop taking cialis and get medical help right away. 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Peyton manning celebrated today with his kids and a parade at disneyland. Last nights win marked his retirement retirement. Carolinas cam newton is being criticized widely for his play on the field and behavior afterward, walking in a postgame news conference. At halftime many agreed beyonce stole the show from headliner coldplay and as usual some of the most talked about moments were the ads from the funny to the bizarre to the controversial. 2when we come bk here tonight, is lighter side of the 2016 race. How a stuffed dinosaur became one of the most youve finally earned enough reward miles on your Airline Credit card. Now you just book a seat, right . Not quite. Sometimes those seats are out of reach, costing an outrageous number of miles. Its time to switch. To the capital one venture card. With venture, youll earn unlimited double miles on every purchase, every day. And when youre ready toravel, just book the flight you want, on any airline and use your miles to cover the cost. Now thats more like it. If you have high Blood Pressure like i do, many Cold Medicines may raise your Blood Pressure. Thats why theres ricidin hbp. It relieves cold symptoms without raising Blood Pressure. So look for powerful Cold Medicine with a heart. Coricidin hbp. Guys, its just the two of you. The setting is just right. Theres something in the air. But heres the thing about half of men over 40 have some degree of erececle dysfunction. Ask your doctor if your heart is healthy enough for sex. Do not take viagra if you take nitrates for chest pain or adempas for pulmonary hypertension your Blood Pressure could drop to an unsafe level. To avoid longterm injury, seek immediate medical help for an erection lasting more than four hours. Stop taking viagra and call your doctor right t ay if you experience a sudden decrease or loss in vision or hearing. Ask your doctor. About viagra. Available in single packs. ray id like to see more of the old lady. Id like to see her go back to her more you know social side. vo pro plan bright mind promotes alertness and mental sharpness in dogs 7 and ololr. ray it was shocking. Shes much more aware. jan she loves the food. ray she wants to learn things. The difference has been incredible. vo purina pro plan bright mind. The latest on a shooting that injured a Sioux City Police officer. Police arrest seven people for local robberies they say are connected to the shooting of that officer. And. A week after the blizzard sioux city is still cleaning the streets. Starting with stranded cars. Super bowl 50 has come and finally month, when it comes to campaign feltoops people here in New Hampshire have seen it all, from the candid to the crazy and now the cuddly. Nbcs Peter Alexander tells us about a fuzzy face who is quite the sensation on the campaign trail. Reporter its only fitting that the Granite State forms the bedrock of american campaigns. This year red and blue are united behind pink in darren garnishs hands. Show meet goods. This is dino, and hes really proven to me how special the New Hampshire primary is. Reporter call it the dinonour primary. One mans nonpartisan pursuits snapping photos of as many possible posing with his favorite childhood cartoon. His approach. I have a Campaign Good luck charm. Would you like to pose with it. Reporter cant say no to that. Nobody did. Reporter candidates and personalities matters as much as what comes out of the mouth. This is the chris christie, like withthonfidence did,he one arm wiwi confidence. This is the rick rry, the governor of texas. Held it up like it was a dead fish. Reporter then theres cruzs cradle and carsons wide grin. Kasich mistook it for a campaign contribution. And no way i was giving up dino. Reporter Hillary Clinton was cautious. She put her arm around me and insisted i was in the picture with her. Reporter and trump played along even though the crowd dnt. Itit been tried before in 2008. A guy inowa passe around mr. Potato head, garnish passed around his kid. I would love to live in a word wre Dino Flintstone influences Global Politics but more it was about appreciating the live free or die state this dinosaur is proving good old retail politics isnt extinct. Peter alexander, nbc news, marcher. That will do it for us o o this monday night. Imm lester h ht reporting from manchester, New Hampshire from. All of yourselves at nbc news, thank you for watching and good night. matt and, im matt breen. Theres new information, tonight, about a sunday morning shooting involving a Sioux City Police officer. 14year veteran officer ryan moritz suffered a gunshot wound to his inner thigh. Sheila Moritz is expected to make a full recovery. The man police say pulled the trigger, 18 yearold isaiah mothershed, also shot himself during the struggle Police Custody at sioux citys Mercy Medical center