. . le freak plays throughout freak out . . . For me . Oh my. gasps what is it . Its samsung gear vr. You put it in there. gasps laughs this is crazy oh my gosh screams wow. sighs laughter youve gotta try this. . Introducing the reuben from subway a sandwich as full of intrigue as it is flavor. Some say it was invented by deli owner arnold reuben. And some insist it was hollywood starlet Marjorie Rambeau in a fit of crazed hunger. Seriously. The reubens past may be debatable, but its great taste is not. Stacked with lean corned beef, bavarianstyle sauerkraut, swiss cheese, and thousand island dressing on new freshlybaked rye bread. We dont know where it came from, but we know where you can get it. Only at subway. Jim here are some of the numbers, as weve played 58 minutes here and the raiders have it first and goal to go. Give it to murray and he runs right into the arms of short. And an meet timeout by carolina, leaving them with one. Phil if youre a carolina fan, you might be going let them score, give us more time and timeouts. No, theyre doing the right thing with two timeouts. That took two five seconds. Lets say they run it again. You call a timeout. Its 1 50 to that would take it down to 1 10. That would give cam newton, bestcase scenario around one minute or 55 seconds to get into position to get a gametying field goal depending on whats here. Jim its been a magnificent second half for cam newton. Next week, regional action, the it all begins at nfl today at noon eastern. Phil do you agree with that scenario . Jim i do. Came out of the twominute warning, the panthers had two. They just used one. You have to play it out. Youre right. Second and goal. And it is incomplete. That was andre holmes and still to go. They decided to go up top. Phil i think they were trying to throw a screen inside but it was not there. Then he had to come off it to his left side. He wanted to throw it the measurey. Nice, safe play. Even if you complete it they jim third and goal. Its incomplete it was klein on the coverage and no flag and janikowski is coming on to the field. Phil he had what he wanted. Just threw it too quick and a. J. Klein, they have they are putting him in tough spots. Its a little stop crabtree just kind of stumbles. Three times today, weve seen this defense thats asking a lot of a. J. Klein to cover receivers in the middle of the field oneonone. Jim how happy do the panthers have to be . They didnt run it on second down. Still have 1 45 to go. Janikowski nails it. Calling, once they threw it on second down, it was incomplete. They were forced to throw it on third to try to score and go up. But the second down play i couldnt disagree with it. A little screen, its safe. Would have kept the clock moving if they didnt score. So you can second guess those play calls but im not. But to go back to a. J. Klein, jim. All those situations they luke kuechly usually. Jim tonight on cbs, 60 minutes with its story on the groundbreaking study on as heimers. Then allnew episodes of ncis, madam secretary, cbs. So the raiders vinleder a 17point halftime lead. Go down eight after 25 unanswered to take a threepoint lead. Janikowski has just converted his 200th alltime field goal at home. Phil well, jack del rio knows an his offense. Still has question marks about his defense. This is where you have an offense in a certain situation and you have to have some closers on the defensive side to get it done. Get it done. Have not gone all that deep, but this one does, however. Beautifully done. Janikowski earning the touchback. Phil in this second half, cam newton has been throwing the football absolutely magnificently. Hes made some bigtime throws. Been right on the money. Jim one of the key things he , people dont understand a team changes its identity every year. The last year, one of the trademarks of the team that went 151, they pulled out games like this. That has not been the case this year. All of those near misses we referred to in the worlds of ron rivera. Could that change here today . First down. Complete. And olsen has hold of it to the 45. Phil what a route by greg olsen. He goes down the field, goes outside and then breaks it back in. Watch this move outside, stop. Cam newton was looking at him the whole way. Great drive starter right there. Jim olsens 600th career catch to. Huge chunks to try to get into range at the least for a ganotying field goal but with designs on something much bigger than that with 1 15 to go. Phil weve watched it. Cam newton has got it going flowing the football now. So if youre going to play soft coverage and break on the ball, get there before he throws a fastball in there, its not going to work. Jim down the sideline and thrown away. As mack was applying push. Push. Phil khalil mack gets some pressure. Make maybe saves a big completion. What a move that time. Newton knows the pressure is coming and just gets rid of it. That was a great spin move. Jim for nose just joining us, mack had a pick six right before halftime. Second and 10. The chase is on and he is forced to just throw it away. It was bruce irvin along with mack. Busting up the play. Phil bruce irvin this way. Mack on the other side. Khalil mack, that san awesome job of bruce irvin is chasing cam newton. So cam newton has to no choice but to throw it out of bounds. Jim they have two downs to pick up 10 yards. And newton takes the final not where you wanted to use your final timeout but not happy with what he saw. Phil yeah, but its the right thing to do. The clock was running down. They were having trouble gettling the formation they wanted and really all rivera is looking for here, give us a good field goal try. Jim ron rivera who agree up a little more of here in the monterey area and he was a raider fan. Jim plunkett was his hero. He has family members who are raider die hearts diehards, come to many of the games. Phil the raiders doinlts have to blitz because they have two terrific outdoor pass rushers. Khalil mack and irvin so they coverage. Jim third and 10, with time. Middle of the field and off the hands of greg ol sewn. Olsen. Phil aggressive throw, 88, greg olsen going right down the middle of the field. A little bumpy. Just enough where he couldnt get both hands clearly on the football. Gets his fingertips. That would have been an unbelievable catch. Jim fourth and 10. It would have to be a 62yard field goal. Too far back. Theyre going to go for it. Fourth and 10. Game on the line. In trouble and the raiders end it phil this is what you have when you have outside pass rushers like mack and irvin. Obvious desperate passing situations. They can finish the game. Capitol hill mack on this side. Here he comes. Just overpowered trea turner. Jim this is very similar to what we saw not that far in here miller who was coming off that same edge wreak havoc on newton. Carr with the glove on one hand, wedding ring on the other. And the raiders about to win their fifth in a row. Phil we talk about it, this will give you confidence. Gives you faith. Your quarterback gets hurt, the game turns around and they found a way to win it and khalil mack and still got in there and stripped cam newton. Jim well, the raiders to go to 92. To stay in that current first position in the a. F. C. Same record as the patriots. Have a strength of schedule advantage at the moment. And this old around for a while and still has some old magic in it. Its the 50th year of the oakland coliseum. And its come back to life with these young raiders. Theyve got their first winning season since 2002 with the victory today. They cant block him and they have a finisher on the defensive side. Jim 3532, oakland victory. Cbs tonight, 60 minutes then allnew ncis los angeles, madam secretary and elementary. For phil and tracy, jim nantz saying so long from oakland. Youve been watching the nfl on cbs. Oh, thats lovely. So graceful. The corkscrew spin, flawless. His signature move, the flying dutchman. Poetry in motion. And there it is, the baby bird. Breathtaking. A sumo wrestler figure skating . Surprising. Whats not surprising . How much money heather saved by switching to geico. Jimse down in atlanta, matt ryan throws an innocent looking screen pass to tailer gabriel. He decisions, zacks, twists, turns past several cardinal defenders. Patrick peterson on his way to a 35yard touchdown. What say matty ice . Thats nice. You support hundreds of growers, including many familyrun farms. Serve customers 390 Million Pounds of fresh veggies. Offer packaging thats better for the planet. And use your size and resources to create healthy change around the world. Because the best way to stay fresh is to never get stale. So can i redeem my rapid rewards points at any time . [lip syncing] any way you want it. Cbs sports thanks you for watching this presentation of the National Football league. [ zaps ] just get a free tv from u. S. Cellular. Free tv . A free 58inch samsung tv when we buy two Samsung Smartphones. Got it. U. S. Cellular, then the bigbox. No, no bigbox we get trampled, you doof ouch ouch get a free 58inch Samsung Smart hdtv when you buy two Samsung Smartphones. And get a tablet for a penny. You werent gonna mention the penny tablet . Captioning funded by cbs and ford. We go further, so you can. This is the headline i saw in the New York Times this morning when i got up here in your city. Whats your reaction . Its a surprise. Its a great surprise. Yesterday i spoke with the president elect. You spoke with trump . Yes. Did he call you or you called him . I called him. Italy and he is behind the next big drama in this tumultuous political year. A potential change in his beautiful but inefficient country that will have ramifications across europe. 60 minutes has traveled to a lot of far off places to tell a lot of incredible stories. But on this trip to the colombian country side we ran smack into a medical detective story, that may end up affecting someone you know and love. After years of research on a unique population of patients, a multimillion dollar nihbacked study has begun to see if the dreaded alzheimers disease may be preventable. If it makes a difference for them, i think theres a reasonable chance it could make a difference for all the rest of people who get alzheimers disease. Im steve croft. Im leslie stahl. Im scott pelley. Im charlie rose,. Those stories, plus a look back at a rare moment with fidel castro, tonight on 60 minutes. Cbs money watch, sponsored by American Express open. Quijano good evening. Cyber monday is expected to be the Largest Online shopping day in history. Opec ministers a vienna on wednesday to discuss plans to cut oil output. And friday the Labor Department is expected to report 170,000 jobs were add this month. [ sneezes ] i have a big meeting when we land, but im so stuffed up, i cant rest. Nyquil cold and flu liquid gels dont unstuff your nose. They dont . Alkaseltzer plus night liquid gels fights your worst cold symptoms. Plus, unstuffs your nose. Oh, what a relief it is. As i was researching my family tree, it was her french name. Then she came to louisiana as a slave. I became curious where in africa she was from. So i took the ancestry dna test to find out more about my african roots. The ancestry dna results were really specific. They told me all of these places in west africa. I feel really proud of my lineage, and i feel really proud of my ancestry. Ancestry has many paths to discovering your story, get started for free at ancestry. Com at t. J. Maxx, marshalls and homegoods, weve imagined the holidays this way for decades. Its why we never have crazy sales. Never make you clip coupons. And always have amazing prices on popular brands and thoughtful gifts. Its time to bring back the holidays with t. J. Maxx, marshalls and homegoods. Hey, need fast heartburn relief . Try cool mint zantac. It releases a cooling sensation in your mouth and throat. Zantac works in as little as 30 minutes. Nexium can take 24 hours. Try cool mint zantac. Rose italy is the stage for the next big drama in this tumultuous political year. Next sunday, italians will go to the polls to vote on a referendum driven by matteo renzi, italys brash and charismatic Prime Minister. He wants to reduce the size of italys senate by twothirds literally getting rid of a monumental proposition for italy, and himself. Renzi argues that italy has changed governments 63 times in 70 years, and trimming the size of government will help bring order to chaos and move the country into the 21st century. The vote will have implications for all of europe, and hinges on the considerable political skills of a modernday macchiavelli a 41year old former mayor of florence, who is the youngest Prime Minister in italys history. bells we met matteo renzi in his hometown of florence, where the renaissance was born, and where it flourished. Matteo renzi this is rose he insisted on conducting the interview in the magnificent Palazzo Vecchio, the old palace, in a room with a renzi yes rose it was only 48 hours after donald trump had stunned the world. This is the headline i saw in the New York Times this morning, when i got up here in your city. Whats your reaction . Renzi its a surprise. laughs its a great surprise. Yesterday, i spoke with the president elected. Rose you spoke with trump . Renzi yes. I called rose did he call you, or you called him . Renzi i called him. And because the president elected deserves a call from the Prime Minister of italy. And i, i wish him every, every good, good luck for, for the next years. Rose did you remind him that you had supported his opponent . Renzi but we dont discuss about it. But its normal. Its the, the great, the great play of democracy. Rose matteo renzi finds himself at the center of a great play of democracy. Italians will vote on december 4 on a referendum he initiated. Constitution by slashing the number of senators in parliament. Renzi italy is incredible. Because italy is the country with 950 members of parliament. The double of the United States of america. Rose the u. S. Has 435 members of the house, and 100 members of the senate. Renzi in italy, the number are 630 in the chamber, and in the senate, 315. Rose a yes vote would reduce the senate to 100 members, who would be appointed and not elected. Renzi believes the change is needed because the senate is the graveyard of legislation in italy. Renzi this referendum is not a referendum to change democracy in italy. It is a referendum to reduce bureaucracy in italy. Italy is the worst country for bureaucracy around the world. And this is very important. If we have a system with a lot is 63 government changes in 70 years. Rose 63 governments in 70 years renzi exactly. Because we have a system in the hands of bureaucracy. Everything is difficult. Everything is complicated. And my idea is simply, give simplicity to italy. Rose renzi is known as the demolition man in italy, because of doing business. Hes already passed a bill that makes it easier to hire and fire workers. Renzi argues that with a leaner senate, he can streamline the way italy is run. History is italys richest asset, but its present is hampered by a bloated and inefficient state. Italys economy hasnt grown for two decades. The Unemployment Rate is nearly 12 . Stuck in place. Many italians are suspicious of renzis motives for the referendum. Virginia raggi this is crazy. This is madness. This is ridiculous. Democracy is the right that people have to choose their, their representative. Rose virginia raggi is the new mayor of rome, who came to office with little political experience. Her Party Opposes renzis constitutional reform. Raggi he doesnt want to change the country. He just want more power. Rose thats an incredible accusation to make. More power to do what . Raggi what he wants. Maybe, all the laws that he want to do without havin a great opposition from the parliament. Rose Beppe Severgnini is one of italys leading columnists. He says renzi personalized the referendum early on, by threatening to quit if the no vote prevailed. His opponents, everywhere the left, the right, the center, whatever we, even within his party. So, in practice, its a referendum on matteo renzi and its him against everyone else. Rose its become a vote about you. And thats not good. Renzi yes. This is, was my mistake in the first days of the electoral campaign. I understand the mistake. I dont i dont accept that people who say, oh, politicians ha mistakes. No. I am an, i am a man. I can make some mistakes. Rose if you can trust them, the polls show the no vote slightly ahead. There have been weekly rallies against renzi and his referendum, some of which have turned violent rose while others have been simply passionate. Si o no . No rose even in his native florence, where banners at a in office for a little over two and a half years, matteo renzi is now seen as the establishment, the vessel for people to vent their anger, in a year when discontented voters are saying no to those in power. Renzi after the victory of trump, a lot of italian populists, ah, we won rose they said trump was a vote for no. Renzi yes. But if trump won in michigan or in pennsylvania, its not the piemonte. Rose europe is nervous. Already rattled this year by the shock of the brexit vote, the European Union needs stability in italy, a country notorious for its instability. . . . And president obama, with an eye perhaps on boosting renzi before the referendum, last month invited renzi and his wife agnese to the white house for the final state dinner of the obama years. If renzi pulls out a victory next week, it will likely be because he is a relentless campaigner and a master of operatic stagecraft. Rose with his tuscan swagger and a florentine ease with the italian language, he is racing around italy like a man who has consumed one double espresso too many. Renzi is a natural politician. He is trying to convince his people that a yes vote is the best chance for italy to move forward. Heres what i hear from you, sitting here in this remarkable place of history. I love italy so much, i want to change it in order to make sure it can be all that it can. Renzi the message is exactly that. After two years and a half, in my chair in rome as prime about the potential role of my country. Rose from a young age, renzi was the smartest person in the room. Rose at age 19, he won over 30,000 on the italian version of wheel of fortune. By age 34, he became the mayor of florence. In 2014, despite not being a member of parliament, he managed to assume the Prime Ministers se it was a move worthy of his fellow florentine, macchiavelli, whose name for five centuries has defined the gaining of political advantage. We are in this city of florence. The home of macchiavelli. Renzi yes. Not only macchiavelli. Not only. Macchiavelli worked exactly in the other room. Rose he worked in there . Renzi yes. And there is the portrait of macchiavelli now. Rose but macchiavelli was about power. Thats the game youre in. Renzi macchiavelli. sigh is hated in italy. Because macchiavelli is the representation as a man who used every way to achieve the power. But i think, macchiavelli is one of the symbol of italian intelligence. Both this is the portrait of macchiavelli. Rose renzi is selfaware, and selfdeprecating. But the joke in italy is that renzis ego is so huge, the entrances to the Palazzo Vecchio had to be enlarged to accommodate it. Here is what some of my journalistic friends have said to me. Hes a man in a hurry. Renzi uhhuh. Rose talks too much. Has tried to do a lot in two and a half years. But they remind me that your matteo, but you are not god. laughs renzi its true. He told me laughs its very funny. But yes, i, i am a man in arena as president roosevelt. Rose Teddy Roosevelt said the man in the arena deserves the credit. Renzi im not interested to change about the government. Im interested to change the conditions for the people. So, yes, i talk a lot. But i think this is the only way for italy in this moment. Rose suppose you lose . Renzi for me, its not important. Im a free man. Im not as the old politicians in italy. The old politicians maintain the chair for a lot of decades. So if we will lose the referendum, this is not a problem for me. Its a problem for the new generation of italians. Because its a lost opportunity. Rose if its a yes vote, severgnini well, if its a yes, yes vote, we have to be very careful. We have to find a way to, to anchor matteo renzi somewhere down to earth, because hes going to float in rome. You see, you look at the sky. This Matteo Renzis floating away. Because hes going to be over the moon. laughs . . . Rose Prime Minister renzi is proud of how once upon a time his native florence brought the west its greatest cultural the geniuses who produced glorious art and Brilliant Ideas are still celebrated here michelangelo; da vinci; galileo. Renzi florence for me is not simply a city. Florence is a sentiment. And i think its impossible to be a politician without sentiment. Rose Matteo Renzis sense of romance about the wonders of florence makes him optimistic renaissance. Renzi with the yes, the italy will start the future. Because in the last 20, 20 years, italy discussed only about the past. Oh, the past is wonderful in italy. Look, look at Palazzo Vecchio. The most beautiful place in the world, in my opinion, i think this is incredible place. But the past is not sufficient. Is not enough. We need the future. Because we are italians. And italy is not only a museum. Rose italy is not only a museum. Renzi italy is not only the this is the point. For adults with advanced nonsmall cell lung cancer previously treated with platinumbased chemotherapy, including those with an abnormal alk or egfr gene whove tried an fdaapproved targeted therapy, this is big. A chance to live longer and is the most prescribed immunotherapy for these patients. Opdivo significantly increased the chance of living longer versus chemotherapy. Opdivo works with your immune system. 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Well, if you want to sing out, sing out . . And if you want to be free, be free . . cause theres a million things to be . . You know that there are . Gs to do . . You know that there are . . . Looking for clear answers for your Retirement Plan . Start here. Or here. Even here. And definitely here. At fidelity, were available 24 7 to make Retirement Planning simpler. Youll always be absolutely. Clear. . Time to think of your future . Its your retirement. Know where you stand. Stahl nobelprizewinng colombian novelist Gabriel Garcia marquez once wrote of a mythical town in the middle of the jungle whose residents suffer from a mysterious affliction that erases their memories. Today, in a region of colombia called antioquia, reality appears to be imitating fiction, in a way that may answer questions for all of us. Antioquia is home to the largest concentration in the world of people who carry a rare genetic mutation that makes them 100 certain to develop alzheimers and as devastating as alzheimers is anywhere, this is a particularly cruel version it strikes when people are in their mid40s, and leads to death about a decade later. It is a tragic situation, but a perfect scientific laboratory. And its now the center of a multimillion dollar, n. I. H. Backed study trying to find out for the first time, whether alzheimers disease may be preventable. These are the Andes Mountains and lush countryside of antioquia, colombia, whose capital city, medellin was once famous for murder and the drug cartel of pablo escobar. Today, medellin or medejin, as its pronounced here is peaceful. But for some families here, theres still a battle going on, a battle against an insidious this family mother cecilia, her seven children, and grandchildren lost its patriarch, alonso. Freddie for me, my father was number one. Stahl freddie, the oldest, remembers his dad always eager to join in and play with him and his friends. Cecilia translated he was a very joyful person. He loved to dance. He was a really nice person, a very good father. Before the disease. Stahl when it first started, what were you noticing that made you think hes hes different . Cecilia translated he started asking, what is the date today . Do i have to go to work . And we got concerned. Stahl alonso at the time was in his mid40s, so the memory loss and confusion made no sense. His doctor suggested exercise and vitamins, but alonso just of his children, getting lost and disoriented. His son victor had to help him get dressed. Victor translated i gave him his shirt, i told him dad, come, ill help you put your shirt on, and the first thing he did was to grab it and put it on through his feet. Stahl did he understand what was happening to him . Victor translated he were moments of lucidity, where he would ask me and say, son, whats happening to me . Why dont i remember . I dont remember my children, or my wife. I dont know who i am. Stahl his son julio took him back to see the doctor julio translated when i asked the doctor, i told him, doctor, i am not leaving here until you tell me what is wrong with my father. Stahl the doctor sent them to francisco lopera, a neurologist at the university of antioquia who knew exactly what was wrong with alonso, because hed become the local authority on a rash of earlyonset alzheimers cases in and around medellin. Francisco lopera they were getting disease very e the life. Stahl it all began many years earlier, back in the 1980s, when lopera was a young medical resident. He had read about small numbers of people scattered around the world who had developed alzheimers in their 40s. So when a 47yearold man came into his medellin clinic with alzheimerslike symptoms, he was intrigued, and decided to investigate. You met this one man, and you decided to go to where he was the town where he was living. Stahl lopera learned that the mans father and grandfather had also lost their memories in their 40s. Then, a few years later, another similar patient came into the clinic, this time a 42yearold woman from a town 40 miles away. Dr. Loperas thennurse, Lucia Madrigal, asked if any of her relatives also started losing their memories when they were young. They told us yes, that the father, the uncles, the grandfather, the great grandfather, so i started making a Little Family tree, on one page, and i showed it to dr. Lopera. And i told him, look what we have here. What is this . So many with the same disease. Stahl and so began a detective hunt that lasted more than a decade. Lopera and madrigal traveled all and more people afflicted with earlyonset alzheimers, and compiling family trees. They thought it might be genetic, so madrigal spent days at parish churches, poring over heavy ledgers where priests for generations had recorded village births, marriages, and deaths. Thanks to these meticulous records, she was able to trace the disease back hundreds of years, and to make an important discovery the different families were actually one huge extended family, connected generations back by common ancestors who had died young, with an unusual cause of death written down by the priest softening of the brain. This is what softening of the brain looks like in real life. Fernando is 46 years old, a descendant of that second he started forgetting things when he was in his late 30s, and now can no longer speak, feed himself, or do just about anything on his own. His aunt takes care of him round the clock, just as she did with his mother, when she got the disease at the same age. Norelly is at an even later stage of the disease. Just 58 years old. Patients were going from mild symptoms to complete dementia and then death within about a decade as dr. Lopera showed us in these cognitive test results. Lopera you can see, at 38 stahl even at 38, this man struggled as many older alzheimers patients do to copy a complex drawing accurately. Lopera at 45. Stahl and things got worse stahl ah oh lopera at 51. Stahl oh dr. Lopera was convinced that what he and madrigal were discovering was scientifically important, but even as they found more patients and more related families, he couldnt get anyone outside colombia to take notice. Until 1993, when a harvard professor came to give a talk about alzheimers in bogota, several hours away. Ken kosik there was a person in the audience, francisco lopera, who came up after the talk and said, you know, theres i have a family here that w has earlyonset alzheimers. Stahl ken kosik, now at u. C. Santa barbara, was that professor. A family. Couldve been four people. Kosik it couldve been just four people. But he started to tell me how many it was. And as i listened to him, i me that i changed all my plans, went with him to medell . N. And we began a collaboration that goes on to this day. Stahl they showed kosik what Lucia Madrigal showed us the family tree they had compiled, based on all that searching through church records, for just one of the affected families, going back all the way to the 1800s. This is one family . laughs madrigal una sola stahl it just kept unfolding. And unfolding. Covering these pages are small squares representing men, circles for women. The coloredin squares and circles mean the person got sick with alzheimers at an early age. Look, she had these sons and a daughter. And then it just kept going down through the generations madrigal si. Kosik when we looked at the family trees, about 50 of the offspring were getting the disease. Thats a clear signature of a stahl but what gene . Kosik connected dr. Lopera with leading geneticists in the u. S. , and they started collecting blood samples and searching. Within a year, a major breakthrough they found a specific mutation in a gene on chromosome 14 one tiny flaw in the d. N. A. Responsible for all this familys suffering. The discovery was published in 1997 in the journal of the american medical association. Lopera had identified the largest concentration of early onset alzheimers cases in the world. If a person has that mutation, do they get alzheimers . Kosik yes, they do. Stahl if they have it, they definitely get the disease. Kosik right. There are some mutations where you dont definitely get it. But this is a bad one. And if you have this mutation, you get it. Stahl for families like alonsos, discovering the crucial first step toward finding a way to fight the disease. But it was also a curse, because it meant that anyone whose parent had the mutation, has a 50 50 chance of having inherited it too. Do any of you know if you have that mutation . Do you know . Victor no. Freddie nobody knows. Stahl nobody knows. Well, somebody knows. Dr. Lopera and his team have been testing for the mutation and compiling a database, but their policy is not to tell family members if they have the mutation or not and not even to reveal the results to dr. Lopera, since at this point, there is nothing that can be done to help. Cecelia translated sometimes i ask, which one will get it . But i throw that thought away, because i dont want to think about that. I pray a lot to god that none of them gets it. Stahl each one of you knows, because of your father, that you have a 5050 chance. So what kind of a weight does that put on you, day in and day out . Julio translated ive even prayed to god that if if theres one person who has to have the disease, i say to god, let it be me. Sara translated i thank god that im a nurse and that i would be able to take care of i had to go through it with my dad, the experience of the disease, and i may have to go through it with one of my siblings, or with several, we dont know. Stahl sara told us she would love to have children of her own, but given her risk of developing the disease, shes decided against it. Sara translated so that my children dont have to go stahl youve been working on this 30 years. How do you cope with all this pain . Lopera crying stahl it was not the response we had expected. Its that hard . Its that hard. But dr. Lopera knew that even in the midst of all this tragedy, there might st hope. Because what he had discovered in these families hundreds of people destined to develop alzheimers, and easily identifiable with a simple genetic test presented a unique scientific opportunity to test whether its possible to step in and stop earlyonset, and maybe all, alzheimers disease before it starts. This cbs sports update is brought the you by ford division. Im james brown with scores from the nfl today. Baltimore survives and regains first place in the a. F. C. North. Eli manning throws three scores as the giants win their sixth in a row. Tampa bay sacked Russell Wilson six times and forced three turnovers to stymie seattle. Atlanta rolls past arizona and remains one game ahead of the bucs in the n. F. C. South. Miami wins its sixth game for ri for more sports news, go to cbssports. Com. With the most 5star ratings. Awardwinning value. And the highest owner loyalty. Giving drivers what matters most. Thats how you become americas bestselling brand. During the ford year end event get an extra thousand dollars black friday bonus cash on top of all other great offers. Its an amazing time . . . . . The joy of creating, the joy of giving. Pandora jewelry. . Some relationships you stick with. Over time, they get even better. Thats why more people stick with humana medicare advantage. We Work Together with you to find the best plan, however your needs might change. Because great things are ahead of you when your health is ready for them. Humana medicare advantage. The plan people stick with. Walgreens presents, a holiday mini miracle. Hey hey . This is for you. Did you really . Didnt have too . Getting the gift you almost kept for yourself, now thats a holiday mini miracle. And it is easy to create your own at walgreens, with 50 off the gifts of the week just around the corner. Way a corridor business is giving back to stahl alzheimers disease is the sixth leading cause of death in the United States. More than five million americans have alzheimers right now, and given the aging baby boomer population, that number is projected to nearly triple by midcentury. Yet unlike many other leading killers, there is no effective treatment. An alzheimers diagnosis is essentially a prescription for a slow descent into oblivion an spatial skills, and ability to think that make us who we are. Earlyonset alzheimers patients, like the hundreds of family members in colombia, are a tiny fraction of the whole, but to scientists, they could be everything. Because they are offering researchers something they have never had before a way to test whether intervening, years before people start having symptoms, might halt the disease in its tracks. Answers are still years away, but with more than 1,000 americans developing alzheimers every day, a way to prevent it cannot come soon enough. The scene we witnessed in dr. Pierre tariots exam room at the Banner Alzheimers Institute in phoenix is one that plays out in neurologists offices every day. Pierre tariot so if i asked you what city were in right now, what would you say . Norm laughs