A nico is in germany to learn german lunch pinnacle. Why not learn with him online, on your mobile and free chest c, w e learning course eco speak. Ah ah. The 1st questions appear as quickly as the cancer. What are my chances . How much time do i have . Medical advances . Mean half of all Cancer Patients can be cured. But those, this report cant be cute. Their only hope, cutting edge cancer drugs, many promise a longer and better life with cancer. And as ive, the exclusion of new medications is a blessing for many patients of the islands. But many drugs do little and escape true evaluation of dental and gain. Many patients have just one choice. Try them and hump oh, im ready comment though. If were honest to the guns. Ellison, we dont know if a drug will work. Informa, why has communist i embark . You cant get a word out. Its like being trapped in your body. Of that, i wouldnt wish that on any one of us on me, and i would never have linked these side effects to this drunken to comment about how safe and effective are these new cancer drugs. How well are they researched before theyre released, then, or is it worth you and us via the money average long were seeing more drugs being fast tracked as a child with less and less certainty about their efficacy on, on his own. Were spending massive amount disregard all scheme 8600000000. 00 euros for cancer drugs each year and the trend is increasing. How effective are they . A marty and drink has had chronic leukemia since 2007, incurable. The disease is always present every day, even on vacations, photos of her last cruise hooked it as the man he had and did look at this. You mason, you are clean cortisone cheeks when it surprises me every time here. Its embarrassing, didnt evict me. Its not, its your life and my life to. Im also tooth athletic about cook my toilet even when i looked so awful. Look how you look at me on my way. Its wonderful. Thought haley adams again. They are. Her 1st serious symptoms appeared in 2013. 0, so she spent 6 months in hospital chemotherapy and high doses of caught his own, brought her cancer under control, but then it returned her rubbing her energy with oh my god. Yes he from london. But his head and it was so difficult just moving from the bed to do a bit of washing up and then back to mahonnan. Done with things like that. If you have to experience it yourself, man, woman, so this exhaustion never ending exhaustion longer does. It wouldnt english about was my experience, maurice surfaced but fear what would have happened if you hadnt received treatment, hickin, and vh thank flow of his gastorm. I would have died until appeared without treatment. How chronic lymphatic leukemia killed you . Logan made some porter with treatment. You can, what does my specialist say . You can grow old with an effective therapy, good, and flea. The chemotherapy wasnt effective just a few years ago, there would have been nothing more for patients like ring. But there are new cancer treatments. And there her hope. Then manzona ish earn, if you have a serious disease like i do me with very few drugs available, then youre trapped to you would are fold that in what you have to say at some point. I know i want to live with lee. I want to sobriety him, youre grateful there. And now so many drugs, speed seller, me to comment and switch and gift. Shes been representing patients for years on various committees. She knows the Health Care System for for them to send them to alicia. She knows that new and promising drugs are always being developed on dustins laws. Ah, modern cancer drugs are often the final attempt to extend the lives of people who have been curable, cancer, the hassle, her community hospital, berlin has allowed us to fill. Despite the pandemic, it has a unique humanist approach, an office state of the art cancer drugs in its certified oncology co units. Each morning, the pharmacies deliver cancer drugs customized for individual patients. In addition to chemotherapy, new immune and antibody therapies, potentially flock said mechanisms in cancer cells more precisely than key my therapy, oncologist on and mrc, has worked at the center for our patient chima treatment since 2017 you him number. And this is an antibody that we often combine with chemotherapy, young visa to antibodies for a Breast Cancer patient like a lock and key for a particular part of the cancer cells. These are some floss patterns and some of the new therapies cost many times more than classical chemotherapy and gorse. I give me the come into the a lot of these very expensive drugs and not designed to cure the patient. Idol author tilapia for they slow the disease of and ideally maintain quality of life when the relations can then remain independent, heightened, lapsed, and they also live longer would, as its vital effect in mouth and even filling up for oncologists like on a missing the range of Treatment Options gross every year. They are currently 237. 00 cancer drugs on the market. A good one, 3rd of which a state of the art cop tales that are recombined again and again for more and more cancer types. He tries to keep track of this market of hope. New marketing materials arrived almost every day. Your mother must been part of us. This is a combination therapy that was approved for prostate cancer. Was 50 percent. This is for female patients with a certain kind of Breast Cancer. You get to say 5 here. There are 2 combinations for patients with malignant melanoma home. And finally, an antibody combination for a specific leukemia hoops and anti copper papa doesnt. Thats 2 or 3 days worth of marketing material i the hog. Im sure all my colleagues receival this to but on the other man at the superlatives of pure marketing for the Quantum Leaps everywhere thing the things. And alice fontainebleau. We cant difficult is it for you to stay up to date does is not hipaa often as of yet not really to lot of workmen zuber you can do it yourself by reading journals. If not, thats a very important source of information without marketing of on babylon. Off either i dont have the time during my shifts to read up because even if needed side, that means i have to use my time off to stay up to date hinder here. And if i typed it in, the tuned us it, me dar by the skin formula to floss up on the cancer would an alarm, a patient in severe symptoms is getting worse. Cancer is very advanced for many patients on this wound in the fight to prolong life, freedom and shot, and his team always looked to the ideal dose and combination of active ingredients quickly with bad news for this patient. This last the count, if we know the liver is massively damaged, if her liver is deteriorating, repudiated, she knows it and wants to go to a hospice. Excellent. So when does cancer . When doth. And when can drugs ward off the victory for weeks or even months . Will the patient even respond to treatment . Difficult questions . It is. Oh, im ready comment, vert, when the guns, if were honest, we dont know if a drug will work in advance in for him on skipped a. M a respond. There are always responders and non responders in teams on behalf im forced back within the patient is told we have a suggestion guide. We recommend this treatment is regularly rises on sol as skipped off of likelihood that it will help is such and such. He does, if it was, he had a lot of people are afraid if theyre uncertain or, and doctor, we always try to offer the patient as much information as possible to make the decision all Time Favorite went off. We dont want them to refuse a treatment that could help him do it. Hows his this is the niche we work in law does faith of india. I let the mines em. Tennyson marian drink also has to research my things up, come to a decision. Ho. Leukemia had progressed and she had to rely on a new active ingredient a promising you combination therapy had been released about 4 years earlier. It was supposedly more effective than classical chemotherapy. If you really had no alternative to didnt typo nice 5 year, not then because we tried the traditional options. The common bush done. When i say we, i mean dr ludovic and die professor lute and nothing really worked and, and conceived nists voc leash bond patient is unclear. Nist on the thing. He carefully read all the studies he could about this drug or dish spite. I met old me again and again in the us there is something we can try. And kelley is that, maam, and an elderly man responded to it very well. I have a daughter mad bohannon and gloves or say a good on and you trust that and fat heart man. All her foolish, she decides to take the new drug. A bruton, it is an enzyme inhibitor that can very precisely slow down the growth of diseased blood cells. Study showed that 42. 6 percent of participants responded well to the drug. But after 2 weeks, something unexpected happened while on a short cruise. Im lets an on mac. It started on the last evening when i said, lets go to bed early. Im a bit cold and chivalry when we got up in the morning and wanted to leave the ship, i couldnt find my wedding ring finger so on. If i always take it off at night, usually i panicked. Reason panic, what was that . Wheres the wedding ring . Wheres the wedding ring . And i had to look for it. I see that it was on her other hand and, and then we left the ship and the situation with the bus made emboss. My mother with called my husband santa fe, comes the bus, get your tickets on me. I opened my wallet and tried to enter a pin game, said out, so my, instead of taking out her ticket over when dot you start thinking, oh, what is this as noon . She was also having trouble finding words or what renew it. Went on the canton. I wanted to tell a friend at our car about our vacation and have him i started to speak, but couldnt get a word out to the status of. I thought why its coming on here is what i couldnt get a single word out to her. Its like youre trapped inside your own body and you know what he want to thank back. Boy, i had the images i wanted to talk about, but nothing came out of the house. Ah, the next day she drove to work thinking the symptoms would disappear, but the opposite happened. She was rushed back to hospital and diagnosed with our trail, fibrillation, a transitory shaming attack or t. I a which it interfered with the blood flow in her brain. Ah, the doctor, treating her at the helios clinic in berlin bush noted. Oh, we diagnose our trio, fibrillation, and t. I a as an undesired side effect of a brute nib as it does a to yard id come years, all this tear, it came on. So suddenly and without warning, i there was no predicting it proceed. Ah, it took half a year to recover from the side effects. Was it a known risk . Ah, her oncologist, professor of t to load vig also chance the german medical associations drug commission. Thats what, what did you know about the drug command . We had no foul nose for fear yarn. When wilson does us, we had about 4 years of experience and knew that it had been highly effective with several patients who had already been treated with of the drugs or had really about us. I need a name, vocal, and keep the of a new a gun fire. We also knew that there was some rear side effects like arrhythmia with more strong and from diarrhea published thomas. And while i prescribed this drug, since i was quite convinced of its efficacy, because other patients had responded, manassas down as outside toyota, and for as a doctor says, you criticize yourself when its a patient with a disease she can live with for 10. I think 2030 years later vanish and then suffer severe toxicity to see that may have serious consequences. We have a photon and as these are toxicity, it had to have gone t i is not listed as a side effect in the 2014 clinical study. Why wasnt it discovered by the manufacturer . Theres man, many guys fired for less than 200 patients were treated in the study and it will, rare side effectiveness and rest. Serious side effects may not be found here. Fast down approved based on a study with a 195, a brute nib test subjects. In 20195 years after the drug was approved, an International Research team analyzed the Worlds Largest w h o database for side effects. At the time, some 90000 patients had been treated with a brute to nip world wide. The analysis showed that 13500 suffered serious side effects. 303 died of cardiovascular disease. 254 had brain blood flow issues such as t i a mazin theodore it and his hours out of this Analysis Shows very clearly that theres a very long list. Even look at some of the side effects, especially the blood flow issues in the brian pixels. Theyre not as rare as originally thought and a name wrong. Its a side effect. We have to inform our patients of emerson, so they can react quickly if necessary and stop take on a drug given and follow schnells he again, colonel medea i numbers. Mm. To come in as alter. Its not until september 2019, around 5 years after the drugs approval that t i appears as a side effect in the Product Description along with the recommendation to regularly monitor patients. We want to talk with the anson the company itself. It brought to nip as improve a car in europe. They offer a written response. Instead, we ask, how do you respond to doctors, accusations that insufficient information on potential side effects was available before the drug was approved. Among other things, johnson refers to a number of studies without stating whether these took place before or after the drug was approved. Quote, over a 150, improve because studies are ongoing, an 8 phase 3 studies in the area of chronic lymphatic leukemia. They continued, we continuously monitor the safety of our drugs and any potential side effects and finally improving his risk profile remains positive. Ah, these new types of drugs brought a new kind of hope when doctor started describing them around 20 years ago. Many even thought the battle against cancer would soon be won. But disappointment followed the euphoria a 2014 analysis of 71 cancer drugs by the American National Cancer Institute showed that the new active ingredients could only slow chima growth by an average of about 2 months. Statistically some drugs only prolong patient life by a few weeks. Not easy for medical professionals who are gaps. My men come in fast. There was a drug that was heavily promoted for pancreatic cancer in their congo. In the end, it turned out that it only barely prolonged life can come in. They asked my house for some people just 14 days during the luncheon. Phillips is still statistically significant. Is too significant. Ok, lets use it. So 10. 00 to 14. 00 days is not a lot over a long period laying on, but its a dilemma for every one. Well, i look at what doctor wants to say. Im not going to offer this drug and this machine ish would have and what patient is going to say thats i dont want it and im, it does really some sub populations dont respond at all as a group. Why . Even use it . All right, well make america, but then you could see that for some patients it did work. Awesome. Then contact, so you can use it in those cases cocked ozium con to look, this is post Approval Research as to how do these drugs work . In reality, revealed is emitted come into integrated how do drugs actually get on the market . What hurdles do they have to clear to be approved in germany . The European Medicines Agency, ema in the amsterdam is responsible for approving drugs. This is where pharmaceutical Companies Ask for approval. They have to prove that a drug or a new combination of active ingredients both works and is safe. The process for regular approvals is always the same. In phase one, the drug is tested on a few patients. Here its about how the body processes the drug in phase 2, the medication is tested on several 100 patients depending on the disease. Here, the efficacy of the new drug is compared to a control group that receives an older one. In phase 3, the drug is given to several 1000 patients. This stage is about determining the safety efficacy and any rear side effects. But this standard is followed. Lesson less frequently. New drugs are being approved. Faster officials want patients to benefit from innovative drugs as quickly as possible. Under certain conditions, drugs can be approved after phase 2. After being tested on just a few 100 people. Wolf, t to load vig represents the german medical profession at the emer. Hes been critical of this trend in oncology for many years. Zeros on is to to slide an ongoing olivia, im very critical because an oncology, we have a significant increase in the number of accelerated approval processes or 2 impact is often not clear which patients would do best with the drug original. And we know too little about safety and side effect emerging authority should only agree to accelerated processes, an absolute emergencies, not, for example, with diseases by cove at 19 corbett noisily. From them we discovered extreme examples like this one approval of a drug for a special chima mutation was accelerated for 17 types of care. So, but it was tested only on very few subjects. For around half of the cancer types, it was tested on less than 10 patients and on just one patient each for appendix, liver and prostate cancers. Since 2015, 28 percent of all cancer drugs have been approved for sale using the accelerated process. The publicly funded institute for quality and efficiency and health care in colon thomas cause a heads up its drug assessment unit. Oh, he looks at all studies published on a new medication. Oh, does of a shiny its glass on phones are showing up on crypt, maybe come in and the her goal of the accelerated approval process for cancer drugs is to make them available to patients fast. Often whats in a sense of awful stead that since we have no data on whether they are better than existing ones, we cant know if patients will actually benefit. Lesters asked, isnt that gang up . Lighting is a percentage them, but in the fonts for tim. Another reason why the institute checks every new drug after approval to see if its better than the current therapy. And he asked his its with us and so found some unzip that and yeah, he does. If we look at these approval processes and we assess every new area, for example, every new cancer type, the drug is approved for the us and we see that only about half of these newly approved drugs. A proven to be more effective than a previous standard treatment therapy. Now, what does that tell you . Is fin the survey me and as kidney, its not enough. I will, thats my m, as its not about saying it always has to be certain that every new treatment is much better than what is already on the market. Unless the chances that it would be good or i would prefer thought that a newly approved drug offers some progress, lessons mini commend the institute was unable to determine any additional benefit from 46 percent of the cancer drugs approved since 2011. Hon skilled eichler. The medical director of the European Medicines Agency e mail in his private office in austria. His familiar with the arguments that the trucks are approved for sale to quickly and better data is needed. It is while much of what the critics say is not wrong. The others, but on the other hand, we have patients who say, what do you really want to wait another 2 years and boy will not do we want to continue to do studies until its too late for me to get this product. This is walter because whats the right Balance Sheet to get by all spoke this present the medically talk about drugs. There is not much data on which cure nobody in mrs. So is it still justifiable to say we have to get all of this on to the market quickly alice . Yeah, it does say that when youre healthy, my guess oldest we hear from patients and patient representatives who are sick seems drops it. They say we dont expect to be cured, we were satisfied if we can see a bit of improvement and give you super bowl saw. So we take small steps that the question is, is a small step reason enough to one, introduce a drug to the market to law, and to do it quickly asked as often back to playing an alternative to barkley is d. O is our uncertainty about the treatment justifiable or not to be totally the but who should have the last word . The dog lets the operate. I think it should be the patient is okay. So you could look at that. I recall, ah, allowing the patients to decide marty and drink would have liked to have know more about the side effects so that she could have been better prepared for the potential risks which died when you were shot at how did i get to work safely . I must have had a really good Guardian Angel until shuts in would sleep. Oh, better it would have been better to have known more not and that this machine will hope. Yes, a fall. Then i wouldnt have gotten my car and put myself at risk. I would have called my doctor that evening from doesnt, does this all, this is what happened. What do i do . And he would have said to yes, go to the hospital immediately and said, dont taking the drug up. Thats what would have happened. Fest funny but psyched our that is the data isnt available. Yeah. And if you dont know that theres nothing you can do and honey, im done how we got the medical world is trying to decide with speed and access to drugs is better than more dasher about efficacy and side effects. And most even sewland important in on patio, we dont want to ask patients to wait for a drug that may cure their serious disease and the talk even thats the problem is that this is only one side of the coins that mark in the, in individual cases you might take this kind of risk in spite of not having so much information under my garnish bath. That is as dinning, but what is ignored . Are those patients who would act differently . Azari is the ones who would say, i want to know more about the benefits of this drug off and what side effects it has on thing. And whether this drug will improve my quality of life compared to the chemotherapy and therapy focus on that mission. Theyre left out in the cold, etc, and, and on patsy. And i can finish them along the lesson. Then some of the new cancer drugs are considered by experts as innovative breakthroughs that work an entirely new ways oncology, co, blockbusters, prescribed in the 10s of thousands of young clerical ward at the half of her clinic. We meet petra milka. Petra physiotherapist has had skin cancer for 6 years. Its metastasized throughout her body. Shes trying to stay active this year because ive managed to get this back a for the past 3 days. Yeah. All right, guy, i wasnt able to lift this leg tone. Im working the upper muscles thats essential for me to be able to walk with the machine gun or oncologist at the time prescribed for the break through drug naval em up. Dr. Freedom and shod surgically removed cancer from her lung to help her breathe better. Who good morning, how are you today . This message is i do, im good to day. I can move by myself again. Cindy cooley, according to the guidelines of the uncle, logical society. New volume up was one of the drugs of choice in her case before they are from my mobile. Oh no. I was told by my oncologist that it was quite new as successful, especially for skin cancel what i need. So i agreed. No hm. Orange of because up as a spot damage, i was satisfied with it time and in the home. There were no noticeable side effects after all. And i put a lot of hope into it off to his many commend cuz its machines to shoot inside with the guns. A number of different studies showed that it can significantly stall the disease sheet or whatever. And thats what often happens. So i did to up in this specific case for the treatment, unfortunately didnt take no the army, the tumor continued to metastasize, funding newcomers, and also we have the data. We base our recommendations on the quote, we have guidelines, but you only see the effect an individual patience after treatment for their therapy. He thought us, what was it like when you got the diagnosis versus does his name, is that its not right to me . Ah, i was devastated. He saw him though and it included the news finding out you might soon suffocate. This comes on as he by nesting. The is he, how are you and whats your prognosis now . Well, the current prognosis is with brain met. Styles is not good, levite new volume up can slow the cancer down significantly. It was one of the 10 highest selling drugs in germany in 2019 once this kind of blockbuster drug is on the market, its quickly copied. Research is now ongoing into around 20 drugs with the same mechanism as no phone. They differ only minimally is present. Stockton, with the challenge of deciding which is the best as we had come before us is hardly any research into whether the 2nd, 3rd, 4th, 5th, or even 6th drug from this group is better than the 1st. That sometimes the argument is we need Something Else because it has certain characteristics and the 6 these better than the 1st one. Unfortunately, we often dont have the studies on them. But the 2nd, 3rd, 4th, 5th, or 6th drug is approved for sale. But there are hardly any studies comparing these drugs, and thats a dilemma when treating individual patients. Petronela is at home again, there was nothing more they could do for her. Luckily, she didnt have any side effects. But then of all im up wasnt able to slow down the metastases. Nocka is one of the 60 percent who according to the studies do not respond to the drug. For around 40 percent of patients, it can be a blessing. It gives them several months sometimes even he is petras hopes, however, have been dashed funded as can spray his feet is an honest conversation with the doctor is vital and immediate. He knows act that they say that was it. I have nothing more to offer you. Its over lining up the mattress. Darcys have all grown youre seeing 1000000, especially the ones in my head by 6 to 10 millimeters. Its miserable when i read that. Id say my prognosis is terrible. How long now a week . A month. Thats what im dealing with. Let me also hows it says im happy to be at home . Actually. Theres no other option. Mosquito niana. Mm mac had died a few weeks after a visit for the patients battle on in hope was the drugs work . How well for how long is uncertain . One thing is sure, the Health Insurance spent more every year on cancer drugs to to longer life expectancies, more patients, many new medications, and ultimately because the new drugs are more expensive than the old once it costs cancer medications rose from 230000000 euros in the 90 ninetys to 8600000000 euros in 2019. How hot a new uncle logical drugs affected cancer. Survival writes the rubber cock institution berlin, collect data from all german cancer databases. Cancer is no longer always a death sentence. Over half the sufferers now survive class crime in cal compares the survival rates over time. His if on my he says the progress in survival rates are in the ninetys. We saw greater progress in the numbers than in the past decade that something on according to the rubber clock institute, the survival rate increased significantly between the end of the ninetys and 2007 by 12 Percentage Points thanks to Early Detection operation techniques, radiation and chemotherapy treatments, the hope was to raise the survival right even further using the new precision cancer drugs. But since these drugs were introduced, the survival rate has only increased by a 3rd. The 3 Percentage Points by 2017 constantly increasing costs and feud, victory celebrations. Was it at least possible to manage the costs of the drugs . In 2011, at the German Government began controlling prices in an attempt to ensure an effective trunks would be available at fair prices. A joint Government Committee evaluates with their new drug is better than the current standard, one year after approval. The final price is negotiated between Health Insurers and manufacturers. Based on the committees conclusions i shop is a patient representative on the joint Government Committee and collect, hello im so we can take a look in here of on one side sit the health and sure representatives and the x big quality institute, which does scientific analysis for the committee and on the other side we are the patient representatives of cindy von and behind are the representatives of doctors and hospitals at sun at so the continental manufacturers, Pharma Companies on my here to the final and our names of Pharma Companies are not involved in the discussions on which are supposed to be independent of in the group noise. They have to work out how good a new drug actually is. And does it offer more benefit to patients or not stella or juggling her to soberly. And the manufacturer can prove that by submitting a fat folder of documents laying out the benefits of their new drug landing con, my son, surveyed soil, usually the talks go on until theres an agreement. No, im minute on income. If the committee decides the drug is better than the current standard, the price can be set higher. If the decision is negative, the price cannot be increased up, whatever the decisions the drugs remain on the market on. So the most one, this isnt really satisfactory either in the food because in reality, the clear cut these drugs havent been sufficiently tested for sale since of em. I think thats a big problem was, was problem where the drugs are often approved to will based on interim results of christmas. And before the study is even completed, the studies are often designed as sparsely as possible to minimize causing costs and maximize speed. Good, because the earlier, the drug is lot in the bast or the farm industry can make a lot of money for you. Good for the farmer. Mostly for once, the drugs have been introduced, no matter how effective they are, the joint Government Committee can only influence the price. We cant move the truck from the market. We do some research, find the industry, Profit Margins are much higher than in other branches. We find information about hebrew trinity to in studies and industry journals. Ah, the research and development should do to need cost around 388000000. 00 us dollars. By the end of 2019, the drug had brought in around 25000000000 worldwide. The emma granted ability of orphan drug status and incentive to develop therapies for very rare diseases. A good idea in theory often drunk state, has compensates unprofitable research into disease is suffered by a maximum of 5 out of 10000 people in the you. Manufacturers have to pay no approval process fees and a granted a monopoly for 10 years. But many of these subsidized drugs have proven very profitable. 0201920. Often trunks generated revenues of over 1000000000 euros each. Had it in both of his organizations. Why this trend is very worrying, because were putting money into the wrong channel affects a contract. But there are many Metabolic Diseases in children, all of a disease ashlyn, where the manufacturers are not motivated enough to spend the money to develop new drugs. In the answer name will normally come in to, so they go jensens butrend, it is ranked 2nd among the highest selling orphan drugs worldwide. The a may cannot remove often drug stages just because an orphan drug becomes a block buster. So we ask where the answer is willing to give up a butrend, its often drug status and the accompanying market advantages or to reduce the price. Yet since response the European Commission decides, and the allocation of orphan drug status and pricing will look at the benefit to the patient as well as the added value compared to alternative Treatment Options. Oh, in addition, pharmaceutical pricing is precisely regulation by law. We follow the joint Government Committees benefit analysis. Oh, the price of the cost of drugs must yield Pharma Companies sufficient returns to incentivize them to do further. Research and development or cancer drugs are the most expensive medications, new gene therapies, for example, which is the subject of intensive research at the moment, cost up 220875000 euros per patient. So costs estimate the cost, the cancer drugs will increase by 10 percent per year worldwide. How long can Health Insurance play alone . Pharmacist wolf can cast back, has the same question. He has internal experience with price negotiations between Health Insurers and pharma manufacturers. Hes now a mediator, an arbitrator when insurers and Pharma Companies cant agree of enough middle answer, thats not enough. If the drug offers additional benefit, a monetary value somehow has to be calculated. Thus, whats it worth is it, who knows the last us does is done. Thats whats negotiated. So there are 2 of those is the additional benefit worth . 1000. 00 euros, or 30000. 00 euros, are called munch. Well, theres the old businessmans rule that the discount is already in the price. Good applies as they over price in advance lies because they know their price wont be accepted by mo, done in Pharma Companies arent charities. They should be able to make profits about one of us, but they should also keep the Financial Capacity of the National Health system in mind from that because thats who they profit from the most often leave. Theyre paid by the baton at the moment. A lot of money is being spent and so grab what you can while you cancelled. It is right now that they have no shade booklet travels, shamelessness in some Pharma Companies, pricing. What is the association of Research Based pharmaceutical companies . Think they to respond in writing modern cancer drugs, give many patients a longer life, which cancer and more and more often without any cancer at all. So new drugs add value to society and the economy valve. Dissolute vague would like to see better data, more money for independent research to better understand the opportunities and risks of the new jogs. Twisted, see its other music, a mentor, the large number of trucks being pushed on to the lucrative cancer. Cut teeth is where you can demand very high prices. You duncan means we already have many drugs we dont need. And as its very difficult for oncologists to separate the wheat from the chaff, with new drugs, lights and suppression. Marty and drink is now taking a new drug for her chronically. Came yeah, its working and she also tolerates it relatively well. Man, atlanta, i promised my daughter id live to be 80. Is marcia. It was a bit uncertain at times her on that im really trying are and its tolerable through stunt thats what do you wish for you. I have the fear that she can continue to live without too many constraints that youre the, that she doesnt suffer too much, even that she can enjoy life. Im near and that she can stay with me for a long time. Ah. Ringback ah, ah, to the point, strong opinions, clear positions, international perspectives. Could turkey soaring inflation and plunging currency, bring down the president , sometimes referred to as test on type for his ability to deflect crises, economic pain is provoking doubt even among staunch supporters. Can turkey survive . Ada went by down to the point to look point. 30 minutes on d. W. Kennedy. Ah. Soccer is a shorter than any colors and the children in this mountain village. Notable wheres blue . The color of her favorite sex is traditions prevent her from going to games and play an insurmountable obstacle. Little girl football on the p starts february, 4th paul, d w 2. Ah ah ah, this is the w news. Will i been from berlin tonight d w. News band in russia the Russian Foreign ministry to
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