to severe ra for whom methotrexate did not work well enough. xeljanz xr can reduce pain, swelling and further joint damage, even without methotrexate. xeljanz can lower your ability to fight infections like tb; don't start xeljanz if you have an infection. taking a higher than recommended dose of xeljanz for ra can increase risk of death. serious, sometimes fatal infections, cancers including lymphoma, and blood clots have happened. as have tears in the stomach or intestines, serious allergic reactions, and changes in lab results. tell your doctor if you've been somewhere fungal infections are common, or if you've had tb, hepatitis b or c, or are prone to infections. needles. fine for some. but for you, one pill a day may provide symptom relief. ask your doctor about xeljanz xr. an "unjection™". is just like our originalhn sandwiches...only littler...so we bought a little ad...on lil jon.