Today, the Federal Reserve will release a statement tomorrow and we could be in for a real market bruising if they dont say the right thing. That fear kept the market at bay with the dow gaining 35 points, although its up ten Straight Days on the s p. S p advanced. 42 , nasdaq climbing, welcome back, apple. Now, i am not for a minute dismissing how important the feds largesse has been for stocks. Lower rates have allowed companies to do exactly what youve done if you own a home. Refinance at lower levels. I dont know about you, i refinanced three times because of bernanke and cut my mortgage bill in half. And thats what corporations did too. Lower rates made it possible to get housing moving again. Punching above its weight in the economy. And although we tend to judge by the new housing starts, its much bigger than that. Banks own a huge number of homes. When that market heated up, it allowed the banks to reverse the losses in the home portfolios and its giving them more money to lend and thats a continuing ongoing process. This quarter, youre going to see a dramatic improvement in loan loss reserves. Finally, we know the easy money provided by the fed flowed into the stock market. Bonds didnt give enough return, so that cash poured into higher yielding stocks. Thats totally over. It was good while it lasted. It ended because the fed lost control of the Interest Rates and they soared at the same time stocks had gotten so high that there werent enough higher yielding names left to buy. Now, so many people believe when the feds done with the bondbuying program, maybe they can find that out tomorrow or its tapering off. As soon as its over, well, they say the car runs out of gas and you cant create gas. I want to tell you how wrong that is. You need to know ahead of the fed meeting why i can be more sanguine than the average bear or bull for that matter. And, by the way, i still accept that the market could be in for a rough couple of weeks here. I say weeks because i know that the when right after when the feds done, whatever its going to do, i have no idea what it is going to do. The next big event will be the bruising fight between the fedup president and the fractious house of representatives, run by the republicans. In other words, we have to run through a gauntlet and its not going to be unlike the one that Clint Eastwood had to run in the movie the gauntlet. You had to be a buyer of clint, aka that broken down cop, but not until the bus started roaring into phoenix, and we havent even started the ride. Heres what i think you need to be knowing and thinking through about tomorrow. Statement comes out at 2 00 and change. A bunch of jokers take the market up or down, big while the statement comes out. While it comes out. Anyone that reacts that quickly is a fool. You cant. This isnt football where you can script the plays. You actually have to think about it. These trigger pullers, they dont think. You get sucked in. The traders among you, as soon as were down or up. 5 , listen to me, if were down. 5 , buy the dip, if were up, sell the dip. Then were going to go back to equilibrium. I dont want to help the traders. I care about the investors. What about investors . Here weve got to be careful because of the gauntlet. Unlike traders, you cant buy the first dip, youve got to wait. And given that this market is the most overbought its been all year, any slipup wont be over in a day. I also think that once this big, bad event is over, were going to be totally focused on the budget talks and the pattern is they start off with hope, then they devolve into acrimony. Then they plunge into total chaos. Of course its possible that washington becomes functional. You can make that bet. So given that ive been unremittingly negative about what will occur in washington, why encourage buying and why not sell everything . One reason is that you should have cash on the sidelines ready for the decline. If you havent raised cash already, you havent been watching the show. Because going into that meeting tomorrow, well, you need some. You always need some cash ahead of a fed meeting, particularly this key one. And given the rest of the gauntlet, you can only commit half of your cash into a weakness down 2 , 3 , then you have to wait until the gauntlet gets really ugly this month. Why only half . Because you never know if someone shows a little patriotism, a little worry about you, about your job down on washington, youve got to have a deal. But if we dont, were going to go down more and you can commit the rest. Now, though, let me give you the litany of why the fed doesnt matter as much as everyone thinks. First, we were the only game in town, we being the United States, and all of our trading partners were faltering, the fed did matter tremendously, much more than it does now. But now that china and europe were on the mend, the domestic economy isnt as important as it was. The fed isnt either. We know chinas going up because the baltic dry freight index keeps rallying and because 25 of chinas exports go to europe, which is turning. While stocks are no longer cheap, were far enough along in the year that managers have to use every price break to buy, not sell stocks. Thats why all week im featuring anointed stocks, the names that have done so well this year that theyre prime to be bought for the next three months in any weakness like i think were going to get. Third and most important, theres a very big change happening right now that wasnt the case even as recently as six months ago. Managements are taking action to increase the value of their stocks, and activists are prodding them more and more which is leading to a lot of mergers and acquisitions. David faber and i talked about this this morning. Saying, listen, a lot more m a activity because of this activist business. Microsoft announced a big dividend boost motivated by an activist, which has been eager to bring out some value. Value that certainly wasnt brought out by the purchase of the nokia handset division. Then we learned Jana Partners just took a big stake in the long underperforming safeway. Started taking a lot of noise. I bet safeway does something to bring out value. Yesterday we had the consolidation of Packaging Corporation of america buying boise, which will lead to supply cutbacks and therefore higher prices. We had allegheny tech throwing in the tungsten towel selling to kennametal, immediately producing about a 10 advance in the stock. And today we had huntsman spending 1. 1 billion to buy titanium oxide business of rockwood holdings. The second largest producer of that chemical out there. This is fantastic news for the glutted business, one that is weighed down, none other than dupont which is trying to get out of the space. Keep in mind, this is all everything i mentioned within the last 48 hours, 48 hours. I think the activist prop and the management prop are on the rise and theres plenty of money being raised in the category to make things happen. Management recognizes the u. S. Economy isnt growing and they are mad as hell and arent going to take these prices anymore. Do not fear the gauntlet. It will give you the buying opportunities you need, provided you raise that cash to take advantage of it before it begins tomorrow at 2 00. There are real props to this market away from the fed. It simply wouldnt be as strong as it is if all that mattered was the fed. So dont freak out. Do board the bus, build a steel cage, strap yourself to the gas pedal. Were about to embark on a gauntlet that could present cheap stock merchandise, but youll have to have the cash to buy them or youll be shot down before you get there. Brett in new york, brett . Caller booyah, jim. Booyah. Caller i have a question about outer wall. I have a position in it and i was wondering if you think i should buy, sell, what do you think. What your i wouldnt touch that thing with a 10foot pole. When you see that kind of guide down, thats just short guys covering it. When a company has to guide like that and really gives you a narrow and negative picture of the business, why do we think its going to turn around in one, two, three four quarters. That was a dismal statement. I read through that and said, these guys have lost control of the business. I dont want to buy a business where management has, i think, lost control of the business. Bill in connecticut, bill . Caller this is bill from connecticut, jim, hello. How are you doing, partner . Caller my question is about abx. Got beat up in the springtime and early summer, went down to 14, now its about 18. 33 and now theyre talking about replacing some members of the board. What do you think about the stock . I alluded to activist situations. They are a highcost producer of gold. I dont particularly care for the gold stocks right here. I do like the gold, the precious metal itself. But anyone who thinks barrick can get something done, its not there to recommend the stock. Whatever the fed throws your way, listen to me, as long as you have some cash raised, youre going to be able to do some buy, buy, buy when we get hit. But we could get hit again during the bruising battle over the budget, and have some cash ready for that too. Mad money will be right back. Coming up field of dreams . Its been an energy trail blazer for the past decade, drilling into some of the countrys biggest finds. Could its focus on a new play drive the stock even higher . Dont miss cramers exclusive. And later best for the rest. The strongest stocks of 2013 could continue to lead this market higher, and all week cramers highlighting the best for the rest of the year. Tonight, Health Care Companies have been top performers. Dont miss the biotech stars that could keep booming, all coming up on mad money. Dont miss a second of mad money. Follow jimcramer on twitter. Have a question . Tweet cramer madtweets. Send jim an email to madmoney cnbc. Com, or give us a call at 1800743cnbc. Miss something . Head to madmoney. Cnbc. Com. Just have to marvel at the incredible strength of the domestic oil stocks. They seem virtually unstoppable. Tonight i want to direct your attention to a smaller, less well known dependent oil producer, carizo, which has been drilling in some of the hottest areas of the country. Company has 54,000 acres in texas. Eagleford shale. 15,500 acres in ohios utica shale. Three of the most sought after shale plays in the country. Now, in the past, carrizo, 1. 5 billion market cap. Its been ramping up its activity in these regions. Things have changed and changed for the better. Two weeks ago we learned that crzo is selling off its remaining barnett Shale Properties and some acres in east texas for 268 million. That cleans up the balance sheet. Really important, gives enough cash to fund the operations through 2014, gets rid of the funding gap. Up and running in the eagleford. It believes it can deliver growth of 45 for 2013. Yes, 45 . Wouldnt be at all surprised if this turns out to be a takeover target, but weve got to talk about that. No wonder they made a brand new 52week high today. The stocks giving us a 70 gain since we spoke to the ceo at the end of february, 70 . Lets check in with chip johnson, the president and ceo of crzo. Mr. Johnson, welcome back to mad money. Jim, great to see you. All right, chip, youre really putting the numbers up. And im trying to figure out whether the numbers are going up. People arent worried about the funding gap, or is it just the properties are much better than wall street realized . Its both. We have great assets in the eagle ford and the utica like you said. Our dry Gas Production in marcellus is the most profitable you can drill. Weve done all that, weve been able to grow cash flow while weve cut off our debt by selling nonstrategic assets and thats brought our debt to ebitda down to a level with our peers. With the exception of utica and the other, theyre all down. Now, thats because you changed your style, or what goes on there . Some people would say, whoa, hold it, why reduce the Capital Program if the assets are so great . Basically when we made the shift from gas to oil in 2010, we bought a lot of acreage that we had to drill up quickly and we ran extra rigs so that we could do that and hold that acreage. Now were trying to better match our cash flow to our capex and try to live within our means, and i think the market respects that, and thats one reason the stocks going up. I always liked the barnett shale, why sell some . The barnett, were just not very bullish on dry gas and other companies that have lower cost of capital will pay us eight times cash flow. We can take that money and drill wells that pay out in a year and a half. Were big fans of mark papa and eog. Your property like that . We moved into the play and basically bought acreage around eog. When we saw eog making a bet that big on a new play, we knew they had some sort of data that the rest of us didnt have, and they did. Is that how it works . You just respect certain players enough that you want to be near them . Thats how we got in. Ive been underemphasizing it, i shouldnt be, because my friends tell me its gigantic. Was it because it was quiet . Its north of denver . No focus . Whats going on there. Its in the play where you cant miss with a straw. And then theres the northeast extension is a little tougher but more profitable when it works. And eog made that work and noble and us bought into it, so we have really the best part of that play. Youre next to noble there . Were all another guy that knows what hes doing. You follow the guys that know what theyre doing. Utica, we went up there and we were hoping for a lot more oil and we didnt get it. We got a lot of natural gas. Whats the difference between your property and that . The acreage we bought is in the southern part of the play in the oil window. We bought acreage next to antero and gulf port. And we know its going to make oil. Pdc has some wells down there that make 1,000 barrels of condensate a day. Thats what we want. They have oil in places we dont necessarily need it. How are you getting your oil to market . Oil is not too much of a problem. Okay. Well, it is in the bakken, i guess. Yeah. All of our production is really south of there, so the niabarra is a little disadvantaged, some of that is going to the west coast. We saw the refining numbers, pretty amazing. Is that part of yours . Some of it goes there. We sell it to middle men and they take it to cushing or california or wherever. But the eagle ford is still one of the most advantaged, because we basically get brent pricing for it because it can go into the refineries making diesel. Thats been great. One of the things that every day i read about some new oil company. That was the Spanish Oil Company the other day. We know that the norwegians want in. Youve been able to deliver a phenomenal 70 return since you were here last time. Is it a fight to stay independent knowing you can produce more for your shareholders . Because every one of the companies your size, i understand, is being circled around. Im sure somebodys studying us, and weve talked to that one Spanish Company before about a joint venture. And we now have joint ventures with japanese, chinese and indian companies. So there are a lot of people who are aware of what were doing. Were just trying to grow as fast as we can before anything like that happens. Give us a sense of where we are as a country. I spoke yesterday to senator max baucus, and as soon as i mentioned oil, he talks about renewables. Is there anybody that cares about the fuel that unfortunately or fortunately every car or truck uses . They do. Im sorry, 20,000 cars. They do care about fossil fuels . Thats right. They dont want to just import them all from venezuela and libya . They dont want to get it all from iran . Some of them are patriots want to get it here . You said it before, we need 16 Million Barrels a day and were up to 7. 6 million a day of production now which was five million a day three years ago. So as we grow that, we can reduce those imports probably down to about six or seven. And half of that is imported, but then we turn it around and refine it and sell it at a profit. So its really not like a loss. Thats a benefit to our country. Well, look, i totally agree and thats one of the reasons i have you on, other than the fact you made shareholders a fortune. So thank you so much. Thats chip johnson, president and ceo of carizzo oil and gas. Take a look at this one, because even at the 52week high, its the market cap that matters. Not big enough. The market caps not big enough for the opportunity in this company. Stay with cramer. Coming up best for the rest, the strongest stocks of 2013 could continue to lead this market higher. And all week, cramers highlighting the best for the rest of the year. Tonight, Health Care Companies have been top performers. Dont miss the biotech stars that could keep booming. announcer scottrade knows our clients trade and invest their own way. 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Last time we talked about netflix, big short squeeze, best buy, gamestop, and trip adviser. Tonight were going to go off the charts and be talking with the help of bob lang. He got boeing at 60 points ago. Hes a brilliant technician who is the founder and senior strategist of explosiveoptions. Net as well as my colleague at thestreet. Com. When you look at 2013s best performing Health Care Stocks in the s p 500, at the top of the list is Boston Scientific and thats back from the dead medical device company. You know i believe in the power of the back from the dead stocks. The next three names are biotech, its celgene, regeneron and gilead. What do these four red hot biotechs look like from a chart perspective . Okay. Lets start with the bestperforming biotech, which is celgene. Thats the maker of revlamid for multiple myeloma. Check out this stock, as you can see, celgene has had an amazing run since mid august, okay . And lang points out that this run has happened on very high volume. See, theres the volume spike, okay. Especially on the up days. Remember, volume is like a lie detector for technicians. The stronger it is, the more likely a move is telling the truth. Because high volume indicates big boys are doing some buying. Thats what makes the stock anointed, when it has massive sponsorship. And the big hedge funds and mutual funds use any weakness to accumulate the stock, which is what im saying. After the fed meeting could get weakness, think of this stock. What else is happening to celgene . Looking at the moving average convergence divergence, thats the macd at the bottom of the chart. This is a directional momentum indicator, chartists like lang use it to determine when a stock is about to change direction, okay . Change trajectory. Its about the inflexion. In midaugust the macd made a bullish crossover. Okay. We get a bullish crossover where the black line crosses above the red one. And this is a very powerful signal. Okay, so we go, see the stock goes up, we get the cross here, and then we get this last cross which then takes you to that. And hes focused right now on this cross. Thats a buy signal for lang. Stock has roared higher since that buy signal. Meanwhile, the williams percentage r oscillator, a measure of whether security is overbought or oversold invented by a commodity trader by the name of larry williams. Shows celgene is in overbought territory. Isnt that a bad thing . Normally it is. Because overbought have come up too far, too fast and tend to pull back, but celgene is known as an embedded overbought. Its shown that it can stay overbought for long periods of time and the stock will keep rallying, another sign that the stock is anointed. This is the overbought right here and then stayed overbought right here. Typically you would see another reaction, boom, not with an embedded overbought. What does lang say you should do with this one . Given the run since june and the weakness over the last couple of days, langs concerned a brief pullback could be at hand. He suggests waiting until the 50day moving average which right now is around 140. So hes saying this is going to pull back. 5 maybe. 5 . As long as celgene holds above that key moving average, lang would do some buying in anticipation of a big run into the end of the year. The anointed one could bounce and go like that. The next best performing biotech, well, one of our favorites from when it was 5, regeneron with the drug for blindness caused by macular degeneration. Look at this thing. This stock has been a horse. And just yesterday, lang pointed out that regeneron broke out over a double top. A lot of guys shorting this thing, saying double top, its going to go like that. No, it broke out, not down, and hit a new alltime high today which is pretty incredible. Now, this ones been a monster performer ever since it broke out in april around 170. So it was down at 170. The chart itself, you cant tell how strong it is, i realize that now. Its kind of bugging me because its really amazing. Its running from 170 to 300. Lang notes that every time the macd has flashed a buy signal here, you made serious money, and regeneron just gave another one at the end of august. Theres the bullish crossover. The black over the red. Since september, the stock has been on an epic run. Right now the relative strength index or rsi and the top its the top of the chart, and the williams oscillator, lang thinks the pullbacks have made great entry points in the past. Right now that floor is around 275. You might want to wait for that kind of selloff before you start buying. That said, if the market remains strong and lang says regeneron will go higher, i say wait for the pullback because of the fed and the gauntlet. Youre going to see this is the mona lisa of charting. Lets see gilead. Look at this. Again, you have to smooth it out. All right. That is just incredible from april. Incredible. Lang sees one of the best trend lines in the whole biotech universe when he looks at gilead. This stock is just going up, up, up, almost in a straight line. They have all the signs of institutional sponsorship we need to see. High volume up days while the williams percentage shows the stock is overbought. We also know that gilead can remain overbought. Thats what happened in july. It stayed overbought for a long time, staying overbought right here. And this one he thinks can keep roaring. Now, i want to highlight a different kind of chart, a mid cap biotech, not in the s p 500, been performing fabulous this year. Take a look at biomarin, whose ceo well be hearing from later on tonight. After building a base for over a month. Look at that base, okay. Bio marin broke out above the ceiling of resistance. A big move at the end of august, and lang noticed this happened on very strong volume. Take a look at the spurt in volume. Last week, though, this thing pulled back from the high of 76. And get this, unlike all the others i just mentioned, lang wants you to buy this right now. Right now. He likes biomarin because its shown amazing relative strength during the market wide rally and youve got a powerful floor of support here at 66. Right now, tomorrow, he says you buy this stock. The other ones, we all want to pull back. Interesting. So heres the bottom line. Weve reached a point in the year where the stocks have been the 2013 strongest performers, keep winning throughout the year. They can show their investors how smart theyve been. This is one area where regular individual investors like you can game the professionals. Just need to know which stocks will be anointed. The biotechs have been on fire and the charts as interpreted by bob lang. You want to buy celgene, regeneron and gilead on a pullback and biomarin right here, more on that one later in the show when we interview biomarin ceo about its revolutionary orphan drug sales and the exciting upcoming pipeline for 2014. Randy in maryland. Randy . Caller good afternoon, jim. I appreciate your insight and enthusiasm. Im calling about aztecs pharmaceutical and its pending merger. Offered to buy all outstanding astex shares at 850. It closed at 854 today. Is that something to buy now or wait until the merger to settle . I dont want you to buy it. The big moneys been made here. Ill find out whether therell be another suitor. I think this ones a done deal. I think you should move on. Caching, caching. We are not arbitrageurs here on the show. Ken in new jersey, please, ken. Caller booyah, jim. How are you . All right. How about you partner . Caller nktr is the symbol. With fda approval of Astra Zenecas new drug, it could result of 70 million to nextar. A drug which is hoping to replace addictive pain relievers like oxycontin. As a result of all of this news, theres been a lot of blogger speculation of a buyout at the 30 to 40 range. Its only at 13, i dont think its going to be there. I havent looked at nextar in years, to be honest. And we have to do a full drill down, because i used to not like this stock. Lets put it that way. I will do a very thorough analysis of nektar to see if its either a takeover candidate or if its going to go up on its own or it its had its run because its up 80 . All right. Im pulling back the curtain on what the big guys are doing right here. Which means the big money is flowing into celgene, flowing into gilead, flowing into biomarin, and its mostly flowing into regeneron. This is the hottest of all, the one he wants you to buy right now. Stay with cramer. Still ahead bionic stock . Cutting edge drug science is making us healthier, and Companies Like biomarin are pushing medicine forward and boosting your financial health. Cramers exclusive with its ceo is just ahead. Tomorrow, kick off the trading day with squawk on the street. Live from post nine at the nyse. You cant hide from weaker earnings. It all starts at 9 00 a. M. Eastern. Anncr expedia is giving away a trip every day. Where would you go . Woman greece. woman 2 i want to go to bora bora. man id always like to go to china. anncr download the expedia app and your next trip could be on us. Expedia, find yours. Transit fares as in the 37 billion transit fares we help collect each year. No . Oh, right. Youre thinking of the 1. 6 million daily Customer Care interactions xerox handles. Or the 900 Million Health insurance claims we process. So, its no surprise to you that companies depend on todays xerox for services that simplify how work gets done. Which is. Pretty much what weve always stood for. With xerox, youre ready for real business. It is time its time for the lightning round on cramers mad money. Rapidfire calls, i tell you whether to buy or sell. Play until this sound and then the lightning round is over. Are you ready skeedaddy . Time for the lightning round on cramers mad money. Start with don in new mexico. Caller big booyah from albuquerque. I want your intelligent and insightful thoughts on my biggest holding, arm holdings, armh. Arm holdings, its like building an empire like what mr. White has going in new mexico. Arm holdings is the Semiconductor Company to own because its got but you know what, right here, right now, intels a buy, im saying it. I think intel will have a strong fourth quarter. Lets go to roy in oklahoma. Roy. Caller as we say here in cramerica, booyah. Booyah right back. It is cramerica. Caller im calling about the chinese google, baidu. It had a really big run. I tell you to buy it, the communist party does something stupid and i look like i got, you know, general tsos chicken on my face. Lets hold off on that one. Lets go to tim in california. Tim . Caller hey, cramer, im calling about coach, coh. Yeah, they had a meeting with a bunch of analysts the other day. Apparently it went well. Im holding off. They have not delivered the last few quarters and the stock is up 15 trade points. I need to go to bob in my old home state of pennsylvania. Caller a big booyah from pittsburgh. Oh, yeah, man. When leveon bell comes back, you better look out, partner. Whats up . Caller absolutely. I want to thank you for your pick, gilead pharmaceuticals, earlier this year. Youre welcome. Caller my stock is zoltek. Ive been looking at this and cabot, another carbon fiber play. These are basic American Companies that do well, unlike the basic American Team that aint doing that well so far. Lets go to paul in connecticut. Paul . Caller hi, cramer. Whats up, paul . Caller cramer, you really helped us make some good decisions with our portfolio this year and we appreciate it. Im calling about cisco. Theyre leaner and meaner now. What can we look for Going Forward . I think the cisco kid is a friend of mine. Hes coming back. Its a big addition to the charitable trust. I think business is smoking and youre going to see that next quarter. Buy, buy, buy. Whats up . Lets go to shawn, uhoh, could be a bears fan, shawn in illinois. Shawn . Caller hi, jim. My question is about arna, arena pharmaceuticals. No, every time i Say Something negative about it, people get very mad at me. I dont want to touch the stock. Dont buy. Many reasons why ive done that. A lot of the smaller Biotech Companies were talking about, theyre too hot. Theyre too sizzling for me. And that, ladies and gentlemen, is the conclusion of the lightning round. The lightning round is the lightning round is sponsored by td ameritrade. For the rest of the year, home gamers like you can run circles around the professionals that run big hedge funds, mutual funds. Im giving you their playbook. Remember what i told you in tonights off the charts. This is the time when Money Managers start to double down on anointed stocks, meaning the bestperforming stocks in the sectors. Which brings me to biomarin pharma, the developer of orphan drugs for ultra rare genetic disorders and i want to apologize in advance, im going to pronounce a lot of stuff that will be difficult for me. Its very difficult. Earlier i explained why biomarins chart is looking red hot. And thats according to bob lang at realmoney. Com. Now ive got to talk about the business. Here we go. Lets give it a shot. The company specializes in enzyme replacement therapies for rare and incurable genetic disorders that otherwise would go untreated. Four drugs on the marketplace. Two of them treat a condition called mps, causes horrific damage at the Cellular Level if left untreated. Another one helps manage pku, which can cause Severe Development problems and neurological issues, and biomarins fourth drug treats a rare autoimmune disorder that causes muscle weakness. These are all orphan drugs, which means biomarin can charge a great deal for them, because they save lives and save the system money, and the insurers welcome these. Together these drugs are racking up over 500 million in sales. They have a lot more room to grow. A terrific latestage pipeline with an enzyme replacement drug for another type of mps that could be approved by the fda in the maybe even the First Quarter of next year, might do 650 million in peak sales, two more orphan drugs that are either in or about to start Phase Three Development including a treatment for pompeii disease, an often fatal disease, which could generate 500 million in sales. Working on treatment for breast and Ovarian Cancer that targets the dna of tumor cells. Stocks up 28 since we heard from the company last, in june, up 245 since i got behind it. Thats right, 245, not a mistake. Weve got to find out more about this company. Welcome back to mad money. Thank you so much. J. J. , i try to get them all in because you unlike most of the Drug Companies i deal with, youve got multiple things. This is not a onetrick pony here. That is correct. We have four products on the market now, and they are the only products that are to treat the indication theyre approved for. Explain to people how the mathematics work. Because theyll say, well, wait a second, were used to pfizer, theyre treating a Million People who have an illness. It doesnt matter how many people, if you can get the right compensation for the product. Yeah. Thats correct. We are only developing socalled orphan drugs where, you know, less than 200,000 patients in the u. S. And so, indeed, we have to deal with very small patient populations, actually most of our drugs are for socalled ultra orphan disorders with less than 10,000 patients. Okay. But we make a very big difference in the lives of these patients. And since there are no other alternatives to our treatments, the insurers, the payers are willing to pay substantial amount of money to help these patients have their quality of life improved. Okay. Now in terms of this vimizine, everything, all the documents, you can read about this company. Apparently the panel will have a lot of questions about the data, but a big pop in the stock just getting preapproval in europe. Why are people so excited about this new drug . Well, again, because this is going to be our fifth drug and this is going to be, again, for an ultra orphan disorder, enzyme replacement therapy. This is similar to what we have done before with two other products. And we have very good phase three data with very significant p value. Patients have no alternative treatment, and the market is substantially larger than our biggest product today. Were probably talking about, you know, 3,000 patients or so, maybe more in the world. Consequently, based on, you know, ongoing prices and reimbursement prices for these kind of products, this product should double or more than double the revenues of biomarin in the next four years. Thats gigantic. It will take the revenues above 1 billion combined with our current. Okay. Sometimes i think when you hear about this enzyme replacement, that might be more of a pipeline drug. Therell be other drugs that come from that drug, no . Actually, no. Just end of the line, really . Because like all the drugs, i mean, they are enzyme replacement therapies also, but there are different enzymes to treat different disease. Each enzyme that we develop is for a very specific disease with a specific genetic mutation. The reason i thought that is because when i hear the kind of things that youre doing and i know theyre for small, targeted population, i would think some of it would have applicability elsewhere, but its all specialized . Very specialized. And theres nothing else for these people . As far as we know, yes. I know there have been press reports. I lost my mom to cancer, and when we got to the Compassionate Care stage, i was doing okay, so i had some money. And i went to every doctor i could find and said, listen, my mom, every test, every test. Ive got to have her on every test. And i know that biomarin as well as other companies have been faced with this Compassionate Care dilemma where people say i want in that test. What do you do in the case of someone who gets involved in social media, like andrea sloan, who is involved trying to get in a test. Its not really your decision, is it . Well, its the fdas decision. Our decision. The issue is that, you know, we currently have a lot of patients that are on expanded access. We had a patient in new york, a patient you met earlier. Yes. Pablo is on expanded access with vimizine. But we prefer to open up our expanded access within a trial where we can check the safety and efficacy of the product. And we like to do it when we have at least one randomized double blind study that shows clear efficacy for the product. Whats been happening for cancer, and you know, its very unfortunate whats happening with andrea sloan, but we only have about 20 patients we treated with our product with Ovarian Cancer. And this is not a randomized study. This was a ranging study to actually determine what we should do next. Our first phase three study will be in Breast Cancer. And one of the reasons why were doing that is there actually are 15 studies right now, and rolling in the u. S. With other competitors to our products in Ovarian Cancers. Theyre alternatives to our product. They might not be as good as ours, we dont know yet, based on profile, we believe our product is the best. But we have no Clinical Evidence that it is yet. So there actually are alternative solutions to the problems that very different from that. This is very different. All right. Fair enough. Actually, also, what were trying to do is we are trying to generate the best Clinical Data as fast as possible to make sure that we can get the product approved by the fda as soon as possible and make it available to the thousands or tens of thousands of patients that need it. Excellent. And maybe one last point that maybe people forget. You know, and its very difficult the situations are difficult because these are sick patients. But in the 90s, you might remember, there was a lot of trials going on in Breast Cancer with bone Marrow Transplant. There was a lot of pressure to get the patients on bone Marrow Transplant and it turned out to be actually negative. It was doing more damage than good. I know. And so you had to be very careful. Absolutely. Well, youve done a great job for shareholders. What a huge ramp right here. Biomarin pharmaceutical. More than 200 gain. And ive got to tell you as i said earlier in the show, i think this is a very strong, major drug company that youll be thinking about for many, many years. Stay with cramer. Time to surrender all hope that washington will ever understand, let alone embrace the fossil fuel renaissance in this country. Yesterday on squawk on the street okay, we interviewed senator max baucus from montana. He was holding a conference on the economy including a presentation involving the bakken shale in north dakota which will soon be producing a Million Barrels a day. I thought, here we go, common sense senator, reasonable state, mining jobs have always been a mainstay of the economy. I asked a benign question, i thought, about whether they would be discussing the positive prospects of all the newfound oil in this country. The senator got right to the heart of the matter. The importance of renewable energy. I almost fell out of my chair. I figured this one democratic senator might actually admit were close to reaching north American Energy independence. Nope, all about the renewables, subsidized power, government helping and industry that cant solve the big issue, which is how to stop importing oil from hostile foreign regimes while creating a ton of jobs in this country. How can this be so hard . I figured he would at least give me some love on nat gas, cleaner, cheaper fossil fuel. No, renewables. I pressed, how will jobs be created if you only get where the jobs are in the bakken, eagle ford and shales nope, wanted to talk about training people. The companies will train them. Theyre willing to pay well above average wages if they can get the people to these godforsaken places. We learned that, did the homework here on mad money. The government doesnt need to train a soul. Its painful even as objections have been met. Two years ago, New York Times went after the Natural Gas Industry saying there wasnt enough nat gas in the country to justify the use for surface vehicles. That train of thought was quickly derailed when the price plummeted and nat gas glut. Spoiled ground water. The claim, environmentalists in canada had a couple of wells leaking gas. The epa was all over it, but upon proper inspection found that there was no issue and no real leak. And then there was methane pollution. Hey, maybe it was as bad as coal. I actually heard that, and then yesterday a university of texas study showed that the government is dramatically overstating the leakage and it wasnt an issue. They seem to be fighting this tooth and nail. While subsidizing the heck out of expensive solar, impractical electric cars and the enginecorroding ethanol that wastes a huge amount of water and causes 40 of our corn crop to be burned every year while raising the price of food for everyone. I think were waging some soft, ridiculous war against energy independence. We export two Million Barrels of gas a day because the rules dont allow us to ship to where we need it in this country. That jacks up our gasoline prices in the northeast, which i now believe is endorsed by our government as a forced conservation measure that disproportionately hurts, you guessed it, the poor. Even the military doesnt seem to care about the leverage we would gain over the middle east if we became energy selfsufficient. The military doesnt care. They want to talk renewables. Its become a religion in washington and im sierra club, i was green peace, conservation. This is a sacred cow that could destroy our nations best opportunity to become energy independent, create more jobs almost instantly. We have such a surfeit of natural gas that we are stopping drilling. Its almost as if were trying to commit economic suicide. Mark my words here, people, were going to crucify our nation on a cross of renewables. Its insanity. Keep up with cramer all day long. Follow jimcramer on twitter and tweet your questions madtweets. [ male announcer ] ok, heres the way the system works. Lets say you pay your guy around 2 to manage your money. Thats not much you think. Except its 2 every year. Does that make a difference . Search cost of Financial Advisors ouch. Over time it really adds up. Then go to etrade and find out how much our advice costs. Spoiler alert its low. Really . Yes, really. Etrade offers Investment Advice and guidance from dedicated, professional financial consultants. Its guidance on your terms, not ours. Thats how our system works. Etrade. Less for us. More for you. Pools. Waffle bars. Fancy robes. Seems every hotel has something to love. So join the Loyalty Program that lets you earn free nights in any of them. Plus, for a limited time, members can win a free night every day. Only at hotels. Com nascar is about excitement. But tracking all the action and hearing everything from our marketing partners, the media and millions of fans on social media can be a challenge. Thats why we partnered with hp to build the new nascar fan and media engagement center. Hps Technology Helps us turn millions of tweets, posts and stories into realtime Business Insights that help nascar win with our fans. Tonight weve got an interesting piece of business. Secondary was announced by five below, f. I. V. E. , a strong regional to National Retailer that we have been behind from the get go. If this piece of merchandise is priced, whats known as in the hole, below the last sale, i want you in it, because i think five belows got a big, big runway. Its a better than a Dollar Store Dollar store. Theres always a bull market somewhere, i promise to try to find it for you here on mad money. Im jim cramer. Ill see you tomorrow. Spotlight. This is james browns cape. Ooh. Oh, no way. You just dont come across capes of james brown. You know, thats kind of like the holy grail of soul music. Do you think somebody would be able to take this and copy it . And a guitar legends legacy. A gibson les paul. Its gonna be worth up to 500,000. Takes an unexpected turn. That would have been really simple for somebody to stick that on there. But they wouldnt have known to do it. Theres a couple of little marks. Theres a couple of little dings. Youre a pompous ass, and youre full of [. ]. Am i . This is bull[. ]. You got a lawsuit on your hands. [rock music]