Republican nomination, and we will go on to easily beat hillary or bernie, or whoever the hell they throw up there. You, we thank you. You are special. We will be back many times. In fact, i think i might come here and buy a farm. Charlie finishing in third place, a surprising strong finish, was senator marco rubio. Many Establishment Republicans hope you can consolidate support. On the democratic side, senator sanders fared very well against Hillary Clinton. Margin of a narrow 3 . Hillary clinton it is rarely had the opportunity we do now, to have a real contest of ideas. Whatally think hard about the Democratic Party stands for, and what we want the future of our country to look like if we do our part to build it. I am a progressive. I get things done for people. Charlie joining me is the chief political analyst at abc news, frank from the new york times, David Axelrod at cnn, and from washington, the editor of wood ago politico. Im pleased to have all of them. Let me start with democrats. It was a surprisingly close race. What does it say about Hillary Clinton and Bernie Sanders in New Hampshire, and the rest of them . Part of what it says isabel iowa. Is about iowa. Nothing ever good happens to hillary there. She approached it with caution. They pour themselves into iowa, and she round out her vote through organization. Bernie sanders inspired a lot of people to come out. It was sort of perspiration versus inspiration. Amongt her, six to one young people. This is a cautionary note for her. This is exactly what happened with barack obama in 2008. He also did very well among workingclass voters in eastern iowa, which should be a cautionary note as well as they move into other states. I dont think it changed fundamentally one other thing, he did very well among independent voters who cannot opt into the caucus. Reasons why New Hampshire is so promising for Bernie Sanders, were independent voters can choose whichever primary they want to participate. Hes doing very well. Ultimately, he still has to solve the question asked whether he can make inroads with minority voters, of which there are very few in iowa and New Hampshire. That will come in nevada and South Carolina. Charlie and what does he have to do in order to make inroads into minority voters . Hard, charlie. He does not have the history of relationship. He does have a story to tell. Interestingly, he rarely tells it, about his early years. Hethe university of chicago, led the first sit in of the separation of black and white students at student housing. He rarely talked about himself. It is an interesting distinction between them. I think it goes to another vulnerability, potentially, for Hillary Clinton. Bernie sanders never talks about himself. He talks about what he wants to do and challenging inequality. Hillary clinton talks about her own experience. That is a big advantage for her, but it necessitates she talk about herself. Voters, who believe they want a candidate who cares about people like them, Bernie Sanders peter three to one beat her 321. He projects that he is intensely involved in peoples problems. She projects that she is selling her own resume. Charlie i hear you. Tell me about republicans, and what happened about the surprising showing, not so much about ted cruz because we knew he had a strong ground game, but marco rubio. Realthink the development was donald comes opportunity to start closing the field. If he had one there, he would have begun the table. That did not happen. Now it is wide open. Charlie is he wounded . . He is, that he has to recover quickly. If you lose his New Hampshire if he loses New Hampshire, it will be a two weekend movie. Marco rubio is gaining ground, and you can see it. Because of his rights, he is consolidating the establishment. Which is funny, because he was a key party candidate. Tea party candidate. I think each one of those three has a path to the nomination, but each one has a problematic struggle. Donald trump has to win New Hampshire. He has to get a victory. I think marco rubio has to figure out where does he win. He cannot finish in a series of second and third. Cruz, he has to win in places that do not have evangelicals, and where the turnout is massive. Charlie what is the best date for marco rubio to win, and where can ted cruz find victory in a state without evangelicals . Marco rubio has to hope donald trump does not run away. He has to finish second. Cruz either is very competitive in South Carolina with donald trump or beats donald trump, in South Carolina. He has to hope it is totally broken up between donald trump and ted cruz. Charlie should we expect john bush tond christie and gang up on marco rubio in New Hampshire . I think that is already happening today. And aead the results, Socket Mobile as the only guy who could interfere with their and saw a guy as the only one who could interfere with continuing in the race. It will be a real question, is this a rubio surge or a media search . Charlie what surprised you . I think rubio surprised me. There is no overstating what a strong night it was. For months, people have been saying he is the one to watch, and there were no numbers to back it up. Doubtnarrative of the about rubio is developing. He had a lot riding on last night. He was only one point behind donald trump. Compare that degree of Media Attention they got, compare how assaulted marco rubio with three weeks from his rivals, whereas donald trump had a long time where nobody was going after him. I think that is impressive. Part of the problem donald trump has is he did not manage expectations during his you were to tell me he was going to get 45,000, you would have said, that is great. He did not manage that well, because he basically set up a scenario where he said, i am going to win everywhere. I thin as he did not win, it is problematic. Charlie and the fact he said he was a winner, winner and yesterday he was not. He flew all around the state saying, the polls show me winning. It wasnt even on the run up. Even on the day itself he seemed to be not very connected with what was happening on the ground. Charlie not only that, he said if i dont win, this is a big waste of my time and i and a lot of money spend a lot of money. [laughter] which is probably accurate. Into a fight got in iowa he was not going to win. Iowa is an organization intensive state. 63 of the voters describe themselves as evangelicals. It was a mistake to invest himself and raise expectations, as matthew said, in iowa. The real question for donald trump, who just recites poll numbers reverentially wherever he goes, that is how he starts speech is if he starts to lose, how long does he have an appetite to stay in the race . I dont think he has a very baristas appetite for that. Is not just the image he is trying to project. His own self image is he is a winner. He is not a winner today. Charlie david, you run big campaigns. campaign, a very smart, well executed, wellthoughtout Political Campaign . Without question. I think he is the most strategic. I have to give marco rubio credit, because he has done a good job gaming the system, and not being everyones second choice. That is beginning to work for him. Has beenbe very strategic. He talked about his father who was a preacher, he plugged into the evangelical network. He organized in a prodigious way, using the kinds of techniques that frankly, the Obama Campaign pioneered in 2008, and perfected in 2012. He has combined a very shrewd strategy with the technology of modern politics. Now the question is, where does it . Ake i think he has an opportunity in New Hampshire. You have a pile up in the the moderate lane, lane. Hes the only guy fundamentally focused on conservative voters. Although they are not a majority the third ofry, voter he is accustomed to, he can do better than people anticipate in New Hampshire, and then move on to South Carolina where i think he will win. Charlie but is his campaign a movement . He really speak to it every turn, conservatives, we dont want to be denied again. I think there is a ceiling support. Port to his we started with jeb bush saying you have to be willing to lose the primary to win the general. Ted cruz is the opposite. He has moved as far to the right as you can go. Charlie and his campaign are political career before . In his campaign, for sure. It was like going to biblical revival on his campaign. This is almost exactly the campaign he ran as an upstart for the United States senate against the dominant establishment. Almost exactly the same. Charlie how . He appealed to the most conservative voters, the evangelicals, and hes doing it the same way. I was surprised most about ted cruz. I agree he is probably the most strategic and tactical. He did not give a speech last night. That was a broader look, he basically did the exact same message, very religious and conservative. It was not expensive at all. It was like, this is you i am and i will fight it out here. The Republican Base is damentally aggravated that against people in washington who believe have compromised with the president , who are part of the process. Ted cruz has stood in opposition to them, very selfconsciously, obnoxiously at times. That plays with the base. I wonder with the run up to iowa, whether all this talk about how the establishment was worried about ted cruz and the establishment wanted to stop ted cruz in iowa, was not working to his benefit in some way. I think he will continue to cultivate a very aggrieved Republican Base for as long as he can. Charlie the physicians the candidates positions the , they cannotok change, as Hillary Clinton did on tpp. Hillary showed an ability to change just when you think she cant. I think we are ignoring her in terms of, she is the big story of the night besides ted cruz. It has been said a million times, Bernie Sanders is a 74yearold selfproclaimed socialist, who is little known outside of new england until six months ago. The former first lady and secretary of state, senator of new york, one of the most iconic this country, she just fought him to a draw. This is a very bad night for her. She comes out of it looking weak. Shes going to get the democratic nomination, but what does this say about the candidates democrats are sending into the election . Charlie what does it say . First speech is going to be known as breathing a sigh of relief speech, thats not exactly a positive message. I am struck by the fact that both parties do seem to be in an antimode. That competes against our very cherished notion that the person who wins the general election is always a person who also is for something, not merely against something. Charlie and optimistic and aspirational. Remember that . Yes, i do. If you listen to Bernie Sanders, whether you agree or not, he gave a very inspirational speech. You would not say the speech Hillary Clinton gave was inspirational. This is what her candidacy lacks. She has to find a way to translate this experience into something that mean something to people in their own lives, and is not just a reflection of her life. That is what she has not yet figured out. Charlie the question for all of you, why not . At her right hand is everybodys judgment as one of the shrewdest politicians of the late 20th and 21st century. People like david and matthew have taught me well, the greatest truism of politics as that elections are about the future. Everything i listen to her, everything about her Campaign Says the past. I will be the continuation of obamas unfinished business. Ita Campaign Event of her, began with a highlight of her life. Like a retrospective. The semiotics of her campaign do ing a new am creat future, it is saying i have a past that makes this something i deserve. Its one of the Key Attributes everything is everyone is hungry for. It is the authenticity. Bernie sanders conveys great authenticity. Charlie and the unemployed revolution. A lot of it is, he is a ruffled guy, it is who he is. There is a barrier voters dont feel they can get through with Hillary Clinton. Whatever reason, it exists. She has a filter which she seems to speak, and words come out that sound very political and calculated. I think theres no doubt young people gravitated to bernie, not just because of what he is saying, and what he is advocating, but because they believe he believes it, and hes real. She seems to be looking for the political language all the time. I do think in the final weeks of iowa, she began to do it she hasnt done in the past, which is fully embrace who she is. Who she is is an institutionalist. She is a tenacious, three yards and a ground of dust cloud of dust person. She has to take that and stick with it, but explain how that pays off for people, and make it more frank. She talks about i did this and i did that. When we ran the Obama Campaign, our slogan was yes we can. Not yes i can, yes we can. People want to believe they are part of a project larger than themselves and larger than you. It has to do with the future. She needs to project that. Charlie but do you think she can . Is striking how much we are having a circular conversation. We were having the same conversation in 2008. Remember when hillary announced in 2015 that this time around, she was trying to beat herself . She gave a very long, boring policy wonk speech that we did not like, and we did not like that, because if that is her true self, we didnt like it. I think she gets caught on both sides. Davids point is really important, in the end, Hillary Clinton is authentic and she is an institutionalist. She is a steward of a process. She is somebody who is a good student, who wants to show up and get it right. That is not as exciting to have a guy in front74yearold, of College Students and say the revolution has begun. That is what he said. [laughter] i dont think there are a lot of americans who want a revolution. She may come president , but she is a very weak general election candidate. She is going to go into it disliked and distrusted by a majority of the country. But the problem is the republicans are in the same place. The nominee of their party is disliked and distrusted. Charlie if it is donald trump or ted cruz, or are you including all of them . I have to give marco rubio little credit. President s that have gone on to win and win two terms, are the ones that ran a general election message targeted to their partys note. Vote. Barack obama started in the andaries, and targeted it, grant us a message start to finish. Charlie yes we can. Yes, hope and optimism. George w. Bush had the same thing. And bill clinton and ronald reagan. Today, marco rubio has begun to sense that if he is a hopeful and optimistic, it may help him win. Those are usually the ones that win. The problem in the Republican Party is though, to win the nomination, and optimistic message is not necessarily a winner. He has at times turned very dark. He has taken very logical positions on abortion, and other issues, i will rip up the iran treaty on the first day, we will grow back various rights. Basically, antiobama positions that play well in the party, but not in the general election. All of that stuff is on tape, all of that will come back. That is the problem for the Republican Party. The internal pressures united deal with to be the nominee of the Republican Party make it a very tough way to win. Republicans may be faced with the idea that maybe the top three candidates are basically key partiers tea party candidate. They were all in many ways, beloved by the tea party. We thought republicans have learned their lesson, but they are picking between three of them. I think they are hoping the tone marco rubio strikes will it hiss his will eclipse social issues. Charlie i wish i could assemble all of you every night. This is a learning experience for me. Thank you david, susan, matthew and roger. We will be right back, stay with us. Michael milkin is here, one of the biggest medical philanthropists in the country. This month, the senate is scheduled to evaluate the 21st which would accelerate regulators review of new medical treatments and boost funding for the National Institutes of health, by nearly 9 billion over five years. I am pleased to have michael mil ken back at the table. Welcome. Tommy this, where are we . I want to talk about Public Health and where we are in terms illness ing major 2016. You have had a front row seat in the last 20 yard 20 odd years of amazing developments. With the help of thousands in of 1998, the tripling of the National Cancer institute nihet, and more in the budget. This is paying off and we are seeing the benefits today. There have been many heroes along the way. One of them was elizabeth glaser, who founded the pediatric aids foundation. Woman. Lievably brave she caught hivaids from a transfusion. She passed away. Her daughters passed away. Her son lives today. But the legacy today, a woman has a 2 chance of passing aids under her child due to modern science, versus over 90 . It has changed the world. Two thirds of everyone living with aids in the world live in Subsaharan Africa. We are going to see Life Expectancy in Subsaharan Africa potential he double potentially double in one generation. It is an amazing thing to see. Charlie because of the development of treating aids, not passing it on to your children, dealing with other diseases. Median age in uganda is 15. The median age for all of Subsaharan Africa is 19. Many of these diseases, by applying treatments and Public Health, diseases we now have solutions for, they will be able to deal with many other challenges of life, but not what has been killing them for the last. Century hopefully, they will have good governments. , because ofust read what is happening today, the mosquito is the most heinous, disease causing species on the planet. Michael well, it is passing on disease. But modern science and technology and it is an issue of what we are going to do. You can develop ways to mosquito cannot breed. The question is, if you eliminate mosquitoes, what else have you done . What other roles have they played in our in life. We need to make sure we have figured out, when you eliminate what they are doing negatively, is there anything they have been doing positively . Obviously, the questions surrounding a virus in south america and central america, and what is going to occur here, surrounds with mosquitoes today. There are two forms. Do we know how to stop a disease . Known solutions today. And much of what has occurred in africa and south asia has been applying things we know, like the polio vaccine, etc. Is, there areent thousands of diseases we dont know the solution to today. But we are on the doorstep today of bringing those under control. So if you remember, the first sequencing of the human genome over 3years, and cost billion. By the college of the president of the National Institute of health. Sequenced ag phd genome and seven seconds in the Fourth Quarter of last year. Down at georgia tech. Therefore, the sequencing of the human genome is all of a sudden becoming affordable and fast . Michael my guess, within a year or two, you will not be treated for many lifethreatening diseases until you are sequenced. I believe in the next 12 months, we will discover, which we already know from our scientists, that you dont have you have aer, mutation. You dont have Prostate Cancer, you have one out of 28 types of mutations. We know that for many as many f 70 of ovarian cancers, they we now know that for maybe 70 that they cancers have similar mutations to a form of Prostate Cancer. There has been an effective drug for that cancer that women will be taking. Those with a certain gene with a risk for Breast Cancer those mutations they have also matched with a form of Prostate Cancer. We will be treating you for your disease not the location of it. Many of our scientists will learn about treatment because we will be able to sequence you and tell you what is your disease not where your disease is located. You will know the diseases genetic makeup. It would change the way we treat people and one of the greatest advances we have had has been the reopening of phase two failed clinical trials. 1 y 4 to 3 or as little as of people had a positive outcome. All those drugs were never approved. We didnt know who they would work on. Now when you reopen the menu sequence them and you find in if case of Cystic Fibrosis you have this mutation this pill works for you. It will work for anyone else. You now know what a high degree of accuracy that you can approve things that may only 1 of the population as a positive response for. Know it will work. We are so optimistic about death rates dropping from melanoma and Prostate Cancer and other kinds of cancer. Other types of lifethreatening disease. Combating cancer with immunotherapy. Milken it is hard not to be excited about it. I first engaged with it in 1995 or 1996. Jim was at berkeley in his and hiswas running out concept was our immune system is smarter than any disease. It is been doing a fantastic job almost are whole lives. Somehow it has missed this mutation. If we could energize our immune system or train it to kill that disease or make that disease look like the measles or some of the disease. When it be great someday if we substantially had a reduction in chemotherapy and we just energize our immune system. Charlie what we know about genes. Milken understanding our genes, understanding our disease. It is more the second area lets call it precision medicine. We are going to define who you andat a molecular level what your issue is that we will deliver something. Immunology will energize your immune system to deal with your disease. The third area is what is happening in stem cells. Those three will revolutionize the way we are treated. Charlie what is your role in all this . What is faster cures . Milken cure all lifethreatening diseases. After the government increase in and 2004. Ween 98 handle fo what can we bring to bear to accelerate the solutions for lifethreatening diseases. The building of disease specific research organizations. The training of those groups. Educations a lot of in congress and government. Convening of our leaders to solve a problem. Academics and disease groups and pharmaceutical companies. We have a conference every year here in new york. Party for cures. Everybody comes together to see what can we do to accelerate the process. What are major efforts was to educate and show the importance of getting the government to approve the National Center for advancing translation of science. That was approved. They got through the senate with the leadership of harry reid and through the house with the leadership of eric cantor. It was signed by the president. No one took credit for. It has a chance to greatly accelerate science. I think there is a promise that this enormous investment by americans and others around the as it needsing off technology. Computers and million times faster. Storage costing one billionth of what it costs. Focusing on Public Health. 50 of all Economic Growth in the world has come from Public Health advances and medical research. Charlie we talked about collaboration of academics and philanthropy and government and the private sector. Both cures and preventions. What is this conference about on march 1 . Milken the same coordination that occurred in medical research you want to see in Public Health. The worlds leading schools of Public Health, the people that are training the next Public Health officials. Instead of competing with each other how can they work out together to create best practices. Consumer products companies. Kilever, nestle, pepsi. Coke, we can sequence your genome and we can see what the genes are in your body. If i am a Consumer Products company and so he said taking this product was doing damage or was doing good, well prove it. Tell me what is happening. Because we can sequence your biome we can start to see the changes in your body just a couple of months from when you are eating and what you are drinking so that the Consumer Product company, the retailers, the products they are selling, thensurance companies what are theyes serving in the cafeteria . Not everyone has healthy vegetables and fruit in the cafeteria. Charlie what you are looking for this conference is to focus on Public Health and better approaches to issues like obesity, Global Health security, hypertension,us chronic diseases, brain disorders. Those kinds of domestic issues. As well Sustainable Development efforts. The wide compass of Public Health. Michael milken 70 of all health care expenditures, the largest part of our economy, our lifestyle related. How you live your life. Charlie this ought not be a part as an issue. Michael milken it isnt. We should get collaboration. This is in one group against another. As a group we have enough knowledge now and we can prove it due to molecular science and technology that we can help you help yourself. What is so amazing is the number one cause of obesity is depression. Its not diabetes and is not cancer. There are so many challenges. We have solutions to obesity and what we need to do is to have an approach where everybody is involved in that process. Charlie thank you for coming. the conference is march 1 and second in washington dc. Charlie the drug war in mexico continues to claim lives and it shows no sign of abating. Male Life Expectancy rates have dropped by seven months throughout the country. More than 100,000 died in the drug war over the past decade. A new documentary shows the struggle to end the violence. Here is the trailer. There is an imaginary line out there between right and wrong, good and evil. I believe what im doing is good. What im standing up against is evil. It is the cartels. They are terrorizing their own country. Now theyre serving to do it over here. Starting to do it over here. They keep getting away. They are taking back what is from the cartel. Charlie the film was nominated for an academy award. Matthew heilemann is the director. I am pleased to have him at this table for the first time. Matthew i read an article in Rolling Stone about vigilantes on the u. S. Side of the border. It talked about a world i knew nothing about. I knew nothing about the drug war. There has been so much coverage of the drug wars in the media and many glorified in the media and tv shows. Cartelwant to do with land is to put a human face on it. Through the eyes of the very people who are affected by the silence. Violence. Journalistst to the. Grouproduced me to a called arizona border recon. My father sent me an article about a group of citizens who are rising against the cartel on the mexican side. They are associated with a larger group. I knew i wanted to create this parallel portrait of vigilantes both sides of the border. I thought was going to be there for about one or two weeks but it turned into nine months. I am not a war reporter. Ive never been in any situation like this before. It was absolutely terrifying journey, i was in shootouts between the vigilantes in the in the and the meth labs dark desert night. Places of torture. Places i never could have imagined i would be in. Part of what happens in the story is that it first it seems evil, everydays citizens rising up against this evil cartel. In the face of ineffective government. , thats the romantic story. Over time the lines became blurry. That is part of the unfortunate tale of what i experienced at gett which was this goal to rid of the Knights Templar andel created a vacuum somebody needed to fill it. Filme by the end of the the cycle repeats itself. How close could you get . Not in terms of seeing the action but getting them to trust you so that they are unrestrained and uncensored and what you hear and say. I was down there for nine months. So much of what i was able to rapport thatgh the i was able to create with my characters. Spent to let i them become comfortable with me being down there. Characterdes our main jose manuel morales, the leader of this group. People on all sides of it. Verything in between one of the things i tried to do was to tell them i have no agenda no goal in mind, no preconceived notions of what i want the story to me. Im here to find the story. That allowed me to get in with all different sides. Charlie is a story that everybody is corruptible . Matthew i dont know if everybody is corruptible. It does corrupt some. I dont think everyone was corrupted. There are many many good forces. What drove me to keep going down there and make the cell was that cell in love with the people. Fell in love with the people. I was deeply saddened by what i saw. The government was failing to protect them. They were living in a lawless society. For many reasons. , the title oft the film is not an accident. Were in cartelou land. A place controlled by the cartels. They acted with impunity. They controlled every aspect of society from the local judicial , they to local police extorted everyone from the local tortilla makers to multinational corporations. Money and fear. Why this Movement Rose up. In some ways it is an incredible timely story. In some ways it is a timeless story. To say whether the cartel is always going to win. I believe in the goodness of humanity. I wanted to believe in the story. Unfortunately my optimism was beaten out of me over the nine months i was down there. Think to say that but i it is a deeply complex problem. We are all complicit in some way a problem. One of the things i tried to do was you become assessed with isis and always conflicts. There is a war that is happening in the country just south of us. Disappeared, never heard from again. Including journalists. And they have been working there a long time trying to tell stories. Are connected to this war. We are funding the war through our consumption of drugs. I really wanted to shine a light. N it provide a window into this world and to see how it is affecting everyday people. At first he was a bodyguard essentially for a main character the doctor. But i have reviewed the film the doctor gets into a plane crash. He almost dies. He is forced to going to hiding in mexico city and recover. In almost shakespeareanean papa smurf did the best he could. Oft ended up happening many the auto defenses started to fight the power. With the dr. Don. The doctor was the glue that held the factions together. The government started to infiltrate the group. As the doctor says the old roman concept of divide and conquer. The group became fractured. That is what led to their downfall. Number this is clipped n number two. The doctor calling on citizens to arm themselves. Charlie so there he is your main character. Tell me about him. He is an incredibly charismatic doctor in a small town. Like many others, after years of terror and living under the , hehts Templar Cartel decided to rise up. Everyone was wearing masks. He is a tall man. 63. Ly much taller than most of the people in the town. Everyone knew who he was. He decided to take off the mask. He became the de facto leader. Charlie is part of the story that you dont know in the end who youre talking to . Matthew as a filmmaker that was the scariest part. By the end i really didnt know who i was dealing with. I did know if it was the cartel or the auto defenses or some version of all three. I dont know who owns whom. Know who is paiying who. The Mexican Government basically legalized the new cartel. Stories is that unfortunately what everyone feared which was anarchy and revenge has taken place. Continue, kidnappings continue. Criminal enterprises. It is incredibly resource rich. If you go out tonight and have a taco the avocado probably came from this region. Orbital he joked. Meth that is from this region. Charlie thank you so much for joining us. See you next time. Tok with all due respect senator rand paul, now that you dropped out of the race, you are sort of an offtherand. Mark hello from our Granite State studios at the Radisson Hotel in manchester, with just a week to go before the New Hampshire primary. President ial races in both parties erupted into an epic war of words on twitter and the campaign trail today. On the democratic side, Bernie Sanders blasted Hillary Clinton in a series of tweets, challenging her progressive credentials more forcefully than