It was huge night for celtic as they needed a win against rosenborg to stay in the champions league. Find out how their third round qualifier went in norway. Good evening. Theres new hope tonight for thousands of families who live with the prospect of passing on inherited diseases to future generations. For the first time, scientists have successfully repaired a faulty gene in Human Embryos. They used a process known as gene editing to correct dna that causes a deadly Heart Condition. But critics are warning that the technique could, ultimately, be used to create so called designer babies. Our medical correspondent, fergus walsh reports. The goal could not be more ambitious. To eradicate inherited diseases. These scientists have taken an impressive first step on a long road, editing dna in Human Embryos. So how is it done . Inside the nucleus of each of our cells is our genome, billions of pieces of dna. It is the Instruction Manual for life. The scientists were targeting a faulty gene that causes a serious Heart Condition. They fertilised a healthy egg with sperm from a man carrying the faulty gene. They then injected the Gene Editing System known as crispr. This scanned the dna like a spell check or a sat nav. It then cuts both strands of the dna and removes the faulty gene. A healthy copy of the gene from the egg was then naturally inserted. Now here are some of the embryos from the study in the journal nature after being edited. 42 of 58 embryos were corrected. They were allowed to develop for five days. None was implanted. We are very excited about this. The research has been welcomed by a team in london. Who have a license to edit Human Embryos. They say the technology could eventually help many families. There are some nasty genetic diseases such as huntingtons or, as in this case, a disease that affects Heart Function later in life, which can basically blight families for many generations. So a method of being able to avoid having infected children and passing on the defective gene could be really very important for those families. Nicole mowbray has the same Heart Condition which was corrected in Human Embryos. She now has a defibrillator implanted in her chest in case her heart stops. She has a 50 risk of passing on the condition but is unsure whether she would ever consider gene editing. I would not want to pass on something that caused my child to have a limited life or a painful life or a life of risk. I mean that does obviously come to the front of my mind when i think about having children. I would not want to create the perfect child. I feel like my condition makes me me. And some are worried Gene Editing Technology could lead to an era of designer babies. We will get into a society in which some peoples children are genetically enhanced and given advantages over other peoples children. People start to be judged on the basis of their genes rather than who they are. As well as ethical issues there are safety concerns. Previous attempts at gene editing Human Embryos in china lead to serious errors in the dna so a lot more research is needed before this could be used to treat patients. Fergus, a lot of hope for some people but will raise a lot of ethical concerns. It will and firstly the hope. There are around 10,000 diseases that are caused by a single error in the gene, most of them rare. The Heart Condition we heard about in the report effects one in 500 people but it is the most common cause of sudden Cardiac Arrest in otherwise Healthy People so it has a big impact. Couples who know they are at risk of passing on a Genetic Disorder is already at options. They can have Ivf Embryo Screening to pick the embryos which do not have the disorder but this technique will give them more options. The ethical debate is very important. It raises theissue, debate is very important. It raises the issue, how far should we go and tinker with nature to have a healthy child . The aims are laudable, trying to edit out diseases, but what if we could edit in traits . What about genes for intelligence or Athletic Ability . The genetics are much more complex than single genes but this isa complex than single genes but this is a debate we need to have but we are many years away from this technique being used to cure diseases let alone enhanced humans. Butjean eddington gene editing Isa Butjean Eddington gene editing is a technology to watch. Four men from the West Midlands have been convicted of plotting to attack police and the military. The Terrorist Cell was arrested last august after the Security Services found a pipe bomb, Imitation Gun and a meat cleaver in one of their cars during a sting operation. Three of the men had met injail and had previous convictions for terror offences, as our correspondent phil mackie now reports. A major alert near the centre of birmingham last august, homes and businesses were evacuated, the bomb Disposal Unit had to be called. It was the culmination of an elaborate operation resulted in several arrests including these men who called themselves the three musketeers. Undercover officers had found a cache of weapons in the back of one of their cars, there was a partially constructed pipe bomb, an Imitation Firearm and a meat cleaver with the word unbeliever scratched into the blade. They found them behind that door which is a small Delivery Business which was a front, the boss was an Undercover Police officer and it had been set up by mis officer and it had been set up by m15 as part of an elaborate deception to catch the terror cell which it felt was plotting to attack either the military or the police and they recruited two of its members to be delivery drivers. Naweed ali and Khobaib Hussain had previously been jailed for travelling to eight Training Camp in pakistan and in prison they met Mohibur Rahman and they left prison with the same extremist ideology. A friend of theirs, takeya azeez, was also recruited, but when they held meetings in birmingham and stoke they were being watched takeya azeez. They believed violence was the answer and they were prepared to use it somewhere in the uk in the furtherance of the ideology so four very dangerous individuals who, if they had not been stopped, would have gone on to cause a loss of life somewhere. During the trial they claimed the police had planted the evidence but their behaviour told another story. They shared extremist material and made contact with the radical hate preacher anjem choudary. The authority were forced to carry out increasingly complex complex investigation by the terrorists have become adept at countersurveillance. The group met in remote locations and did not carry phones to avoid being tracked. As more people with Terror Convictions are released from prison this could create further problems. The fact that people are being released and you know they are terrorists, they have been convicted of the offences, they released back into society and there is no reason to think they have been de radicalised. I think society has asked the question, are you happy with that . In a statement the Ministry Ofjustice said it had acted to house the most is observed this subversive prisoners in specialist units to stop the influence. It is likely the four men will be jailed, three of them for a second time. Prince philip has bowed out of public life after almost 70 years of official engagements. The 96 year old made his final solo appearance at a parade of Royal Marines at Buckingham Palace this afternoon. He announced his retirement in may after completing more than 22,000 solo appearances. 0ur royal correspondent Nicholas Witchell reports. It was the kind of Afternoon Weather Wise which might have made anyone glad to be retiring, quite apart from the fact that in the dukes case hes been doing this sort of thing for 70 years. But there he was, on the forecourt of Buckingham Palace, a man of 96 standing to attention in the pouring rain for the salutes he has heard so many times. There were many things to remind him of the past decades. The parade had been mounted by the Royal Marines, the fighting force which is part of his beloved royal navy, in which he served in world war ii. And in the background was the palace, the headquarters of the monarchy, the building where his wedding to the then princess elizabeth was celebrated in 19117 when his life as a royal began, and where he has attended so many events, the Garden Parties and formal dinners alongside the queen in the years since. The worlds most experienced plaque unveiler throughout it all the duke has retained his own style, always direct and often humorous. This afternoon he strode across the palace forecourt, no stick for him and woe betide anyone who might suggest such a thing. As he went, the crowd outside applauded. By now it was almost time to go. The Royal Marines gave him three cheers. Hip hip hurray the duke waved his hat and turned to go. And as he did so, the band of her majestys Royal Marines played for hes ajolly good fellow. After 70 Years Service and with his own separate programme of royal engagements now concluded who, today, would have dared to disagree . Nicolas witchel, bbc news, Buckingham Palace. President trump has tonight signed into law a bill imposing sanctions on russia, over its policy in ukraine and its alleged meddling in last years us president ial election. But afterwards he released a statement calling the measures seriously flawed. Lets get more from our north america editor, jon sopel. So he signed it and criticised it . You almost said he signed this piece of legislation with a heavy heart and one of the tell tale signs of that was there were no cameras present to record him signing it. He says it encroaches on executive authority, it is the president who makes foreign policy, he said it will damage American Companies and it is against european impress as well. He also said he recognised it was the will of the people that it should be signed and soak for the sake of unity he had gone along with this legislation. At the end of this statement he said, i built a truly Great Company with many billions of dollars. This is a big part of the reason i was elected, as president i can make far better deals than congress. He can make far better deals than congress. He clearly can make far better deals than congress. He clearly is unhappy with it but it has not stopped a russian counterblast. The Prime Minister medvedev has said this will do deep damage to attempt to put Us Russian Relations on an even keel. It is tantamount to starting a trade warand it it is tantamount to starting a trade war and it will be deeply damaging and the Trump Administration has absolutely no power in reining in congress. What is ironic about what donald trump has said is that he seems to be far more critical of the legislation that he is for the reasons the sanctions are being introduced, namely russian interference in the us election. Jon sopel interference in the us election. Jon sopel, and cute. More than a million women in their early 60s have become poorer as a result of the governments State Pension reforms, according to new research. The Institute For Fiscal Studies say the women are losing on average more than £30 a week while the government is saving more than £5 billion a year. But ministers say the changes ensure pensions are fair and sustainable forfuture generations. Emma simpson has been looking at the plight of some of the women affected. No trips to the pictures. No trips to the pubs. My life, my lifestyle, has changed. I cant do the things i used to do. Shirley from aberdeen is 61. She cant work because of ill health, and she cant get her State Pension either for another five years. The effect it has had on me. Ending it all. Because. Having to. Rely on your family. But my son said to me, he said, mum, you brought me up. You always gave me when you had it. Now its my turn. But its still hard. For decades, the pension age has stayed the same women retired at 60, men at 65. But by 2020, both men and women will have to wait until they are 66 before they can draw their State Pension. The changes for women began in 2010, and it all depends on your date of birth. So, for instance, if i was born before the 6th of april 1950, i would still get my State Pension at 60. But if i was born two years later, i would get that benefit at 62. And if i was born a couple of years after that, then i will be 66 before i draw my State Pension. This former Pensions Minister told me the government was right to take action on the spiralling pensions bill. But. Given the savings of many billions of pounds that the government is making, a small amount of that could be allocated to helping those women that have been pushed into poverty, bridge the gap between when they would have got their State Pension, and when they will now receive it. Women have been campaigning for that. Ministers insist the changes are fair, we are living longer, and women retiring now will get a State Pension longer than previous generations. Theyjust need to get there. Emma simpson, bbc news. Almost £200 million thats whats expected to be paid for the brazilian Footballer Neymar In A World Record football transfer deal. The 25 year old says he wants to leave his current club, barcelona and move to paris saint germain. If the deal goes ahead it will make him the most expensive player in history. 0ur Sports News correspondent Richard Conway reports from paris. A hasty arrival for neymar at barcelonas Training Ground this morning. But this slow burning Transfer Saga appears to now be reaching a conclusion. After saying goodbye to his team mates, his strike partner lionel messi took to social media to wish him well for the future. And this is what barcelona will miss. Neymar, a star for both club and country. Todays destination was unknown but according to one of his representatives the poster boy of brazilian football is likely to be a psg player by the weekend. Translation yes, paris made a proposal, they are going to pay the clause. The planned Dealfor Neymar would set a clear world record. Back in 2009 Cristiano Ronaldo joined real madrid for £80 million. In 2013, gareth bale made a move also to real for 85 million. Then last summer Manchester United signed paul pogba for the Current Record sum. But at £198 million neymars fee would eclipse them all. Psg are owned by qatar. The gulf state has a world cup in 2022 to prepare for. But this mega deal is a sign that despite being subjected to an economic blockade by four other arab countries it will not be cowed or diminished in its international dealings. What we are seeing here is qatar saying we want to be considered to be a serious power in the business of football. We can bring lots and lots of commercial endorsements to the game. We can have a bigger influence on a global scale, notjust on a european scale. There is no finer example of doing that in signing one of the worlds best. Back on the streets of paris theres a sense of disbelief this deal appears to be finally happening. So too about price tag. I like paris and i think he can make a good thing in this team. It is too expensive but it is neymar. And so the stage is set. Paris st germain will likely welcome neymar as their new Leading Light within the next 48 hours. This is a most political and financial of transfers but ultimately he will be judged by what he does on the pitch. A brief look at some of the days other news stories. Deaths caused by Drug Poisoning climbed to over 3,700 in england and wales last year the highest number since records began in 1993. The figures cover legal and Illegal Drugs but there was a particular spike in the number of deaths involving cocaine. A Light Aircraft making an Emergency Landing on a Portuguese Beach near lisbon has come down among sunbathers, killing two people. Local authorities said the victims were a 50 year old man and an eight year old girl. The pilot and co pilot were unhurt. Rashan charles, who died after a police chase, did not swallow a controlled substance before his death. Thats according to forensic analysis provided to the Police Complaints watchdog. It is investigating what happened as police tried to detain mr charles. His death sparked a number of protests, including one which turned violent. An inquest has been told that a british man who died fighting so called Islamic State in syria, killed himself to avoid being captured by the group. Ryan lock, a 20 year old former chef from chichester had been fighting alongside Kurdish Forces when he was wounded and surrounded by is fighters. 50 army cadets aged between 12 and 17 have had to be rescued in Northern Ireland after getting into difficulties. The group, who had travelled from england to the Mourne Mountains were caught in bad weather. 16 of them were understood to be suffering from hypothermia. The Ministry Of Defence has confirmed that all are now safe and accounted for. Chris buckler reports. In the wind and the rain, rescue teams battled to get cadets off the mourne, mountains and into ambulances. The teenagers from the Cleveland Army cadet force had come here to camp and to learn skills in the great outdoors. But this became a lesson in survival. At lunchtime today, in what were described as treacherous conditions, the Northern IrelandAmbulance Service declared a major incident. And called in extra help to get the cadets to safety. Have you nothing. The reports from the scene were much worse, the Weather Visibility was down to about 20 yards at that stage. The factors working against us here have been the weather, which is much better now than it was when this Operation First started. Also the terrain and this happened in an area thats difficult to access at the best of times. The weather can change quickly at the mournes and camping high up the mountain the cadets werent prepared for the arrival of high winds and heavy rain. The Ministry Of Defence has described this as a remarkable Rescue Operation and they thanked all the teams involved for getting the cadets safely off the mountain. Some of those brought down on stretchers were treated for minor leg injuries. Others, for hypothermia. And they all return home with an experience rather more than they expected when they went to camp. Chris buckler, bbc news at the Mourne Mountains in county down. After months of unrest, the president of venezuela is due to swear in members of a controversial new assembly which he hopes will promote peace. But the opposition says it will give him unlimited powers. It comes as the british based company that provided the technology for venezuelas Voting System says their machines were tampered with and the turnout in sundays controversial election was inflated by at least one million votes. It has all added to the growing tensions in the country as our correspondent katy watson reports, from the capital, caracas. Shouting for help, this was the moment Former Caracas mayor Antonio Ledezma was dragged away in his pyjamas by venezuelas intelligence service. Theres panic while someone screams, the country is now a dictatorship. Mr ledezma had criticised sundays vote in a video posted online. Under house arrest for allegedly planning a coup, the government said he had broken the rules by speaking out and so sent him back to prison. But mr ledezmas daughter told me he had no choice. He thought i cant stay quiet and in silence when i saw this murder, more than 120 murder by policemen in the street. You and your step father are the only members of the family who now live in caracas, your mothers in madrid. Do you feel scared . Yes. Tonight, more criticism of the vote, this time from the company that provided the Voting System. They said the government had inflated the numbers of people who had turned out by over a million. Although many believe it to be more. Based on the robustness of our system, we know, without any doubt, that the turnout of the recent election for a National Constituent assembly was manipulated. 0pposition politicians have called for a criminal investigation to be opened. Theyve criticised the new assembly from the start, arguing that a body designed to rewrite the countrys constitution was undemocratic, a power grab. The head of venezuelas electoral authorities says the voting companys comments are irresponsible and baseless. The Maduro Administration isnt bowing to pressure, either here or abroad, saying the country is now at peace but few agree. Clemente drives a taxi in a shanty town outside the city. I asked him what happened to his windscreen . Translation Opposition Protesters broke it when i went through a road block because this taxi was given to me by the government. I am fed up. Politics is like a marriage, both sides need to sit down and talk. The oppositionjust thinks about themselves. Venezuela would be better off without them. The concern among opposition politicians and the International Community is that that could be the countrys new reality. Katy watson, bbc news, caracas. There are warnings that the overnight care system for people with serious Learning Disabilities is on the brink of disaster. A leading charity says a change in Government Policy has led to demands from the taxman for backdated payments for workers. Mencap says the total bill could top £400 million. The game of thrones star, kit harrington, has been raising awareness about the issue and hes been speaking to our health editor, hugh pym. Do they go together in groups to do their activities . With time out from his filming commitments, Kit Harington is campaigning for a cause close to his heart. Hes concerned about a financial threat to charities which run supported homes like this for residents with Learning Disabilities. What is her favourite song . He is worried about the future care of his cousin, who has Downs Syndrome and Learning Disabilities. He needs to live the life that he loves living. When my aunt cannot care for him in the way that she has, we need to find that for him, my worry is that we will not be able to. Care workers who stay overnight used to get a flat rate of around £30, including when they were asleep but after a court ruling, employers now have to pay the minimum wage for every hour, around £60 a night. They have been told to fund six years of back pay, which they say is unaffordable. What is your favourite colour . Ahmed is a care worker with mencap, he does several sleep in shifts each week. He says getting what he is owed from previous years is important. He knows that charities will struggle to find the money. It is a sense of reward, an incentive which would boost my morale, and my motivation, to do what we do right now, even more. Unions say it is only what the care workers deserve. They need to be paid, they have done this work already. Because of the important work that care workers do, they deserve to be paid this money. A Whitehall Spokesperson said. Kit believes the government has to find the money. Charities cannot pay this bill, if they cannot pay this bill, then people like the guys that are here, who we are here with today, will be left without the care they need, and thatjust cannot happen. It needs to be. It needs to be footed by the government. He is echoing the fears of Charity Care Providers that being forced to find the money will lead to closures the World Athletics Championships get under way in london this friday. For years, these familiarfaces have dominated british athletics. But as stars like mo farah prepare to run their last track races, Natalie Pirks has been considering who will pick up the baton once theyre gone. Gold for Great Britain again expectation, rather than hope. So successful have british athletes been over the last few years that golden moments have become the norm. But guaranteed medals are a thing of the past. Jessica ennis hill has retired. World champion long jumper Greg Rutherford is out injured and sir mo farah is bidding farewell to the track after london. I have achieved what i wanted to achieve. And it would be nice to be able to finish on a high and i guess why not do it where it all started in london, that track. Wanting to become olympic champion, thats what changed me as an athlete and then you come back years later as a world champ and, you know what, im going to end it at that track. Well, this really is aggressive running from laura muir. So who are those moving into the spotlight . Laura muir is aiming to do the double in the 1500 metres and the 5,000 metres, despite fracturing her foot injune. Look at the grit shes showing here. Currently studying to become a vet, the 24 year old juggles her love of animals with a tough training programme. Shes set five british records in the last 12 months but she wants much more. Its great breaking those british records, yeah, i am very happy i have done that but theyre meant to be broken and i am sure down the line there will be somebody coming up breaking my records. But love to get those medals because they stay with you forever. Uk sport has targeted six to eight of those medals, a big ask for a squad juggling injuries. But the Bigger Picture focuses on the next generation. Born just a few miles from the London Olympics site Nethaneel Mitchell blake is britains second fastest 200 metre runner of all time. The 23 year old believes its time now for new athletes to write their own chapter in britains sporting history. People have seen the kind of Changing Of The Guard in our sport, what miss ennis and mo farah have done is remarkable and their fates cant be reaccomplished because theyre legends in their own right. Theyve made their legacy and i believe people coming through want to build their own legacy. Its always hard to say goodbye but fond farewells bring new beginnings. Podium places might not be as plentyful in these championships but the potential for future olympics will shine through. Natalie pirks, bbc news. Newsnight is coming up on bbc two