Planet. All the damage microscopic agent. Lindsay moran is exc. I. A. , shes about to join them. Entering a biolab. Sorry, we cannot confirm your identity concern . What is going to be like ebola, but we havent seen it yet. Dr Charlotte Mcshane is a mechanical engineer. Tonight what she learnt about tornados. Phil torres. Im phil torres. m an entomologist. Thats hour team, nout lets do some science. Hey, guys, welcome to techknow, joined by dr ross shimabuku, and lindsay moran. Microscopic things have been making news. Viruses. Take ebola it caught america offguard. In some places we overreacted and in other places we doesnt do enough. Theres a lot of scare around ebola, because we dont know much about it, compared to measles. Which is also a hot topic. When we think of diseases we tend to think of containment. How do we contain them. I had an opportunity to meet a small group of scientists who are seeking out the pathogens in order to understand it. It might surprise people that metropolis. Thats good reason for that. Lets have a look. Reporter we are all vulnerable to the tiny viruses. Microscopic agents causing big diseases. Reporter these infectious agents know now boundaries and in todays hyper connective world, they can move fast. Like others, like small pox are eradicated. Others spring back to life when we are not vigilantful. Safety. More than 400 in mexico have contracted measles. Reporter then there are the new kids, s. A. R. S. , avian bird flu and ebola. Emerging viruses cause twothirds of recognised diseases in the world. Reporter scientists are trying to unlock the mystery of how they infiltrate us. To study them, you need to contain them first. The need neidl is one of those places. In boston im standing in front of a 200 million facility, a biosafety building for lab, a prison for pathogens like the ebola virus. We have been granted access before it goes hot that is plays host to the worlds most lethal viruses. People call the containment lads containment on steroids, because of the enormous number of redundancies and safety measures. Tour. You are Walking Around the outside of the biosafety level. The people inside are working with bio safety level two ates in preparation for getting the laboratory operational. Reporter inside researchers wear airtight positive pressure suits, also known as space suits, and have their own separate air supply. What makes a bio safety level 3. The key one is engineering. Buildings have to be built as a continuous pour concrete, so heb you decontaminate you can fill them with Hydrogen Peroxide and destroy everything in the room. Reporter its a building within a building. Yes. Reporter the bsl4 has a 16 inch heavily rebarred concrete floor, embedded in the bedrock. If there were an earthquake the two buildings would shape independently. Keeping pathogens secure during death. Bio safety level 4 is restricted to the pathogens considered exotic, and for which vaccines. Researchers must pass through stainless steel doors set up as air locks. Its a chemical decontamination shower that scientists must stand under after doing research in. Bsl4. There are other similar safeguards. John, associate director of reference safety took me through the guts of the needle. Where are we now . We are right above the biosafety level4 labs in the mechanical space. This serves the labs. The majority of what you see, these are housing. Hefa, higher efficiency particulate air filters. They filter out particles, and think viruses. Air goes through the hepar filter twice before being released to the outside world. Liquid waste is treated in a different way. These walls have double wall piping. We have a sample here. Reporter what is the point of the pipe within the pipe. If the inner pipe that the liquid is flowing through develops a leak, it would flow into the outer pipe and become tamed. There is senses there alerting the building automation system. There would be an alarm. Waste is disinfected, and it flows to the tanks, where they are heated at 120 degrees for 60 minutes, to kill off anything that might remain. And then, of course, theres the human factor. Ill tell by the positive pressure suit that we wear in the bsl4. And ill hopefully get you into this. Reporter okay, ive got my right . Not quite. You have jewellery on, rings, Diamond Rings can compromise the gloves. Off. You see the air drops. When the air comes in through the hose, push the collar, as soon as that is connected and locked in, you have air flowing as you can hear. That is what you need to breathe. Its really important to ensure the integrity of the suit before you put it on. It looks like its bearing up very well. Make sure that all of the seams are good. Reporter its like checking a raft. It is. Reporter after rechecking for holes, researchers get in the inner layer. Before getting in this is something we have to do, put the gloves on, and wiggle your feet to the booties. Its making me think the getting my kids into snow suits. You want to reach behind you with your right hand and find the inner seam here. Reporter duck my head in. Yes, there you go. I would plug into air. There you are. Good. Reporter its different comfortable. Its like ventilated pyjamas. Only after training and security background checks are scientists given clearance to do research in the bsl lab. Please move a little back from the camera. Identity. When i think of the scientific community, i think of a different culture than the security community. Is there a clash of culture in a facility like this . Yes. I think its a healthy clash. Its part of the every day resistance. If you want to study these pathogens, you have to develop a Comfort Level with the security pathogens. Reporter security is so tight that even for demo, this was the end of the line for my access. Despite this, the n i. E. D. L has faced a number of political ramifications. This was completed in 2008 but will not be operational until this year. Right. One of the things the country asked for is give us a risk safety that honestly evaluates scientifically the risk of a Community Like this, in the end was a Risk Assessment that says these facilities are incredibly safe and secure, and the chances of multiple failures leading to a release of a pathogen that would influence the population is next to zero. Zero coming up next meet the virus hunters. We want to develop tools, understand the evolution of the pathogens. We want to hear what you think about these stories. Join the conversation by following us on twitter and at in the heart of bostons south end research on some. Deadliest diseases will begin in the n i. E. D. L. Ronald heads up the building, and has assembled a team of virus hunters. Their mission to keep a step ahealth of dangerous pathogens. Its not hard to predict the next breakout, but theres a animals. They are spillover. Not common in humans, but when we come into contact with infected animals, we dont have immunity to them. When viruses jump species, its called zoouno sis, and transmission is more common. Researchers believe that patient zero, for the outbreak of ebola, was a 2yearold in guinea, and came in contact with bats, while playing in a hollow tree. The director of tissue imaging, and a microbiologist who species. We want to develop tools to understand the evolution of these pathogens, what signals might there be that says the virus is acquiring the ability to infect different species. Reporter in order to study how the pathogens evolve he uses recombatant technology. Genes from jelly fish are fused with the viruses. That gene makes a protein which whenever we shine a light on it, a blue light, it blows bright green. That allows us to sensitively detect where that virus is from the minute it infects a cell and produces genetic material. This is a single cell infected. See the spikes. It sticks nice and tightly to the cell. You can go in really, really close reporter even in the still you can see what is happening. We understand the bits of the cell that the vir suss hijacking virus is hijacking, you can interfere with the process. One of the diseases is not one of the emerging viruses. Its one that has been with humanity for thousands of years measles. Measles virus is the most infectious human pathogen on the planet. It beats ebola. It gates flew it beats flue. The viruses no, no borders. We want to understand the basic people. Reporter basic research of measles can lead to pathogens. If you think of measles, its a bsl2 ategent. We vaccinate the workers and it allows us to develop tools and techniques, and approaches, and then move in a direction where bsl3 pathogens and pathogens. Reporter once they are set up to work in bsl face, another team will prepare the supply of viruses needed for research. What we will do is. This is the director of biomolecular production, and is no stranger to the space shoot, spending two decades researching the family of viruses that ebola belongs to. What is it like to work wearing one of those cumbersome suits. Its habit. Reporter you like it. Its a quiet world. No one distracts you reporter she has pioneered studying outside these settings. At that time i was interested in the machinery the viruses bring in to amplify their own genome. We came up with a system to study the process to be used in a bso 2 setting. I remember for the first time seeing how it worked, it worked. It was one of the best moments in my life. Reporter eureka moments are rare in virology, when they happen, they have the potential to save millions of lives. Basic treatments lead to treatments, vaccines and diagnostic tools. Microbiologist worked with engineers to create a device to diagnose ebola. There was a good survivor rate when people are identified early and treated early in west africa, getting a diagnosis is not fast. Samples need to be sent to a specialised lap, often hundreds of miles away. Days. What we settled on is a technology where basically what we do is take a silicon chip, and we can put capture agents that will bind to the ebola virus. And if the virus is present, the antibodies will capture the virus, and we can shine l. E. D. Light on to the chip. This is the type of result you get back where you can say on the positive tests here, you can see theres a strong signal. Results are available in an hour. Devices are portable and can be operated at the point of care. Can it be used to diagnose other infectious diseases. Yes, you can imagine, dividing it into parr asites and others, to a small chip will give you a good powerful asset that is such and sensitive. Reporter what is coming up next. What will be like ebola, but we havent seen it yet . I dont know that we need to go looking for the next ebola as an unknown. The next outbreak is likely something that we know about already. It underscores the importance of not focussing on them in a way its a catch 22. We have to study the diseases to under them. But it makes people nervous, even the thought of having the pathogens around. Just because the pathogen is not here now doesnt mean it cant be flown over on an air plane. Our best defense for Public Safety is to understand the diseases and find ways to treat them where they are. Thats the importance from a Public Health perspective of having facilities like this in the united states. Thats why we have to stay a step ahead of them, we bring them in here to work with them we were afforded a unique window of opportunity. Once the lab is hot, therell be interviews. This is a brief window that we were able to get in there, see how its done and get out before the viruses. Exactly. There were some viruss in thatting about. Yes, but not bsl4. Bsl4. Thats the big leagues. Yes. Many of us read books like the hot zone, or seen contagens, oroutbreak, it makes for great danger. How close is it . Pretty close. As i toured the facility i had thought of some of those movies. But the reality is scientists working day in, day out, leaving strict protocol and i left with far greater confidence that Something Like that couldnt happen in the united states, or it wont happen soon. There are people looking out for us. Very smart people looking out answers. That was an amazing story, showing us what its like there. From ground zero of the pathogens to ground zero of the tornado. Next . I got to step inside a tornado lab at university. I got to feel like beyonce, swirled around in [ music ] hey, guys, welcome back to techknow, im phil torres, joined by dr shini somara, and lindsay moran. One of my favourite things about science is we are able to capture Mother Nature in a lab, take the phenomenon and see them at a university. Yes, theres nothing more amazing than being able to recreate weather, thats what they were able to do at texas tech university. I got experience a tornado, lets take a look. My first shoot for techknow was all about tornado technology, which was incredible. Thats my area of expertise. It was so exciting flying to oklahoma and texas, where we got to see the facilities being used to research tornados. The passage of this is to learn about the Innovation Incorporated into building regulations to keep people safe during a tornado. At texas tech they establish the wind institute. And its there that they have one of the largest tornado simulation laboratories. This is vor tech. Its great meeting the professor, who talked me through the design of the lab. We create tornadolike things that mimic the wind speed. He is making the steps to understand how tornados are formulated. Essential. Theres a lot of different types of tornados. We can mimic them in here. By creating a scaled down version, you can see how it takes shape from the pressure senses to temperature, to the sped some tore and the abbing seller some terse. That technology was underneath. Ill go turn it on and well have some fun. You had the slits in the floor in the lab. Through there he can release smoke. That was a beautiful moment for me. I have only seen how air flows on a computer screen. I could see up close and personally how the smoke was formulating into a complex air flow. Twisting, turning, hair was going everywhere. Felt like beyonce for a moment. It gave me goose bumps that he was creating a space that could mimic the forces of nature. This is the start of understanding how they not only formulate, but how they impact scaled down models of typical homes i got to play with one, and you can see it lifting off its feet. That happens in real life. Possibilities are endless in terms of understanding the effect that tornados have on ou lives. I spent 4. 5 years studying how air flows, but using computer simulation. But i have never experienced air flowing against my skin with that kind of force. This kind of experimentation is important. Yes, the engineers are having fun creating a lab like that, and its necessary for improving building codes and making shelters safer for people. Having grown up with the iconic whiched ard of odd, tornado was a fear as a kid. I cant imagine what it would be vortex. Its a problem with tornado in the united states. On average, they get 1,000 a year, and the next highest rate of tornados is in canada, and they get 100 a year. From the microscopic viruses and lab to tornados, scientists have the work cut out for them, approaching this in creative ways. Thats to this week on techknow, be sure to check us dive deep into these stories and go behind the scenes at aljazeera. Com. Drilling in the arctic. Rapid change is always an alarming thing to see. As the ice caps recede. And the ocean opens up. How can we protect our Natural Resources . This is what innovation looks like. Scientists reveal cuttingedge technologies. You can look beyond the horizon and extend your reach. That could avert disaster while helping save the planet. I feel like i have a front row seat for some very dramatic changes