Set to be demolished are Parker Hall, Noyes Hall, Read Hall, Loeb Hall, London Hall, Neff Annex, the Columbia Professional Building and the Old Student Health Building.
Mizzou North, on Business Loop 70, will be vacated. A buyer is being sought.
"Through this plan, we are eliminating space costs that allow more funds to be reinvested back into our research and educational missions," said Gary Ward, vice chancellor for operations, in a news release.
The Mizzou North sale will eliminate the largest amount of deferred maintenance among the projects, nearly $55 million.
The building demolitions come after the opening of some new ones, including the 47,000-square-foot, $24 million Jeanne and Rex Sinquefield Music Center a year ago. There also is the new Center for Missouri Studies and State Historical Society of Missouri.