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LUGANO, 7 May, 2021- Findings presented at today's EADV 2021 Spring Symposium suggest that an imbalance in gut microbiota (dysbiosis), could play a significant role in the progression of inflammatory skin disease, Hidradenitis Suppurativa (HS). HS is a painful, long-term skin condition, with a chronic and relapsing nature that significantly impacts patients' quality of life.
Researchers at Hacettepe University collected faecal samples from 15 patients with HS and 15 age and sex matched healthy individuals and analysed regions of the bacterial 16S rRNA gene to investigate differences in their gut microbiota. Researchers found that the relative abundance of three genera of bacteria (known collectively as Firmicutes), unclassified Clostridiales, unclassified Firmicutes and Fusicatenibacter in HS patients were significantly lower than that in controls (p = 0.005, p = 0.029, and p = 0.046, respectively). Reduced amounts of these bacteria are known to disrupt the regulatory balance within the gut and stimulate an inflammatory response.