<ul> <li><strong><em>New </em></strong><strong>Lancet Psychiatry</strong><strong><em> Series highlights the overwhelming evidence for the role racism plays in mental health disparities among Black people living in the USA. </em></strong></li> <li><strong><em>Improving the mental well-being of Black Americans requires acknowledging and confronting systemic racism in the US political, social, and healthcare systems, and the long history of dehumanisation, oppression, and violence that Black people living in the USA have suffered.</em></strong></li> <li><strong><em>The Series underscores the need for Black sociologists, anthropologists, scientists, researchers, physicians, clinicians, and citizens to set the priorities and provide perspectives.</em></strong></li> <li><em><strong>The authors call for a community-centred and culturally informed approach to mental health care that is inclusive, accessible, and promotes empowerment and resilience among Black communities in the USA. </strong></em></li> </ul>