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An increased risk of death was seen with higher levels of autonomous cortisol secretion (ACS), a new study found.
In a retrospective cohort of patients with adrenal incidentalomas, plasma cortisol level after a 1-mg dexamethasone suppression test (DST) had a linear relationship with mortality risk, reported Henrik Olsen, MD, of Skåne University Hospital in Sweden, and colleagues.
Specifically, patients with a cortisol DST of 5 µg/dL or higher had the highest risk of death -- over three-fold higher -- compared with those with a cortisol DST less than 1.8 µg/dL (HR 3.04, 95% CI 1.86-4.98), they noted in the