Tella then doubled the Saints' lead at the hour mark after benefitting from another Ward-Prowse assist.
The right-winger, thus, ended his unimpressive run of form in front of goal at St. Mary's Stadium this season.
1 - Nathan Tella's goal was his first for Southampton in his 21st appearance for the club, just 98 seconds after coming off the bench in this match. Automated. #SOUFUL— OptaJoe (@OptaJoe) May 15, 2021
Fabio Carvalho reduced the deficit for Fulham in the 75th minute after receiving a timely assist from Bobby Reid.
With eight minutes before the end of the game, Tella set up Theo Walcott with a brilliant pass to seal the victory for Southampton.