Taconic Biosciences Launches New COVID-19 Mouse Model
Expands COVID-19 Research Toolkit with novel hACE2 AC22 Mouse
RENSSELAER, N.Y., April 29, 2021 (GLOBE NEWSWIRE) -- Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces the launch of a new COVID-19 mouse model. This human ACE2 (hACE2) transgenic mouse expands Taconic's COVID-19 research toolkit.
In October 2020, Taconic launched its first hACE2 model. The AC70 mouse experiences a lethal response to infection by SARS-CoV-2, the virus that causes COVID-19. Conversely, the new AC22 mouseis lethality-resistant, enabling therapeutic, vaccine, and post-infection symptom research.
Although various hACE2 mouse models of lethal SARS-CoV-2 infection exist, the hACE2 AC22 lethality-resistant model is important because it permits study of sublethal infection. Most humans infected with SARS-CoV-2 survive, and an animal model which replicates sublethal disease and recovery is needed. The hACE2 AC22 mouse provides a longer study window to assess drug efficacy compared to lethal infection models.