The omicron variants of the SARS-CoV-2 virus have rapidly spread around the world over the past year. They latch onto our cells more tightly, invade them more efficiently, and elude many of the antibodies induced by previous infections and vaccines. The human immune system, in turn, tends to respond less effectively by producing antibodies related to previous infections or vaccinations, instead of bespoke antibodies tailored to the newer versions of the coronavirus that causes COVID-19. Findings from this latest study in Nature suggest that vaccine developers make sure vaccines against new variants don't contain components from older variants. These might set off the immune imprinting that can induce a less robust immune response to new variants.