Stealth BioTherapeutics Announces Poster Presentation at American College of Cardiology (ACC) Annual Meeting

Stealth BioTherapeutics Announces Poster Presentation at American College of Cardiology (ACC) Annual Meeting
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BOSTON, May 17, 2021 /PRNewswire/ -- Stealth BioTherapeutics Corp (Nasdaq: MITO), a clinical-stage biotechnology company focused on the discovery, development, and commercialization of novel therapies for diseases involving mitochondrial dysfunction, today announced that the company is presenting a poster at the 2021 American College of Cardiology (ACC) meeting being held virtually from May 15-17, 2021.
The poster entitled "Elamipretide Improves Functional Assessments when Compared to the Natural History Progression of Cardiomyopathy-related Disease Symptomatology in Patients with Barth Syndrome: A TAZPOWER Analysis" presents data from a Phase 3 retrospective natural history control trial comparing the cardiac and functional effects of elamipretide on Barth syndrome patients at week 72 of the open label extension portion to a natural history control (NHC) cohort derived from a 9-year long NHC study and matched using propensity scoring. The cardiac findings show that long-term treatment with elamipretide results in significant improvements in left ventricular stroke volume, which continue to strengthen over time with elamipretide, and which would otherwise be expected to decline during the natural course of the disease.  Significant improvements were also observed in distance walked on the six-minute walk test and other functional endpoints, which also strengthen over time with elamipretide and would not be expected to improve during the natural course of the disease.

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