The stores, which have been closed since December 2020 in line with Covid restrictions, opened on Monday.
The hospice, which is based in St Asaph, has 10 charity shops across North Wales and a distribution centre in Bodelwyddan.
Val Corner, retail operations manager, said, “We are very excited to be re-opening our stores and we’re looking forward to being able to welcome back our fabulous volunteers and the public. Our network of charity shops is a vital part of the fundraising efforts for the hospice and the money we raise helps to support the local community.
"Safety measures are in place to make sure that people can shop with us safely."